Abo Bibliothek: Guest
Digitales Portal Digitale Bibliothek eBooks Zeitschriften Referenzen und Berichte Forschungssammlungen
Critical Reviews™ in Eukaryotic Gene Expression
Impact-faktor: 2.156 5-jähriger Impact-Faktor: 2.255 SJR: 0.649 SNIP: 0.599 CiteScore™: 3

ISSN Druckformat: 1045-4403
ISSN Online: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukaryotGeneExpr.2017019418
pages 237-246

TSG101: Tumor Susceptibility Gene 101 (tsg101) Product−Role in Therapy Against HIV/AIDS

Muhammad Imran Qadir
Institute of Molecular Biology and Biotechnology, Bahauddin Zakariya University, Multan, Pakistan
Maria Zafar
Department of Pharmacy, Quaid-i-Azam University, Islamabad, Pakistan

ABSTRAKT

HIV infection presents a major community health hazard, partially because the HIV virus is capable of evading antiretroviral therapies. Most anti-HIV drugs were intended to target virus-encoded mechanisms; however, some host-encoded molecules comparatively execute a vital role in the life cycle of virus. Thus, these might be considered as target sites for antiviral agents. TSG101 is important among these antiviral therapies because, as a cytoplasmic molecule, it facilitates viral budding and release. In this review, HIV-infected cells have TSG101 on their surface and thus can be used in antibody-based therapies. The development of a monoclonal antibody CB8-2 lessens the assembly of viruses from infected cells. This mechanism represents the potential use of TSG101-directed antibodies to fight against AIDS.


Articles with similar content:

CD28/B7 Costimulation: A Review
Critical Reviews™ in Immunology, Vol.18, 1998, issue 5
Khuong A. Nguyen, Vijay K. Kuchroo, Edward A. Greenfield
Tumor Antigen Presentation by Dendritic Cells
Critical Reviews™ in Immunology, Vol.30, 2010, issue 4
Nina Dickgreber, Ian F. Hermans, Troels R. Petersen
B-cell Defects in Common Variable Immunodeficiency: BCR signaling, Protein Clustering and Hardwired Gene Mutations
Critical Reviews™ in Immunology, Vol.31, 2011, issue 2
Ewoud B. Compeer, Annick A.J.M. van de Ven, Joris M. van Montfrans, Marianne Boes
T-Cell Immunity to Influenza A Viruses
Critical Reviews™ in Immunology, Vol.34, 2014, issue 1
Weisan Chen, Li Chen, Katherine Kedzierska, Ken Pang, Sergio Quinones-Parra, Emma J. Grant
The Pathophysiological Role of Chemokines in the Regulation of NK Cell Tissue Homing
Critical Reviews™ in Oncogenesis, Vol.19, 2014, issue 1-2
Giovanni Bernardini, Angela Santoni