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Critical Reviews™ in Eukaryotic Gene Expression
Impact-faktor: 1.841 5-jähriger Impact-Faktor: 1.927 SJR: 0.649 SNIP: 0.516 CiteScore™: 1.96

ISSN Druckformat: 1045-4403
ISSN Online: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukaryotGeneExpr.2019025074
pages 47-50

Expression of Gstt1 in Type 2 Diabetic Retinopathy Patients

Saima Sharif
Department of Zoology, Lahore College for Women University, Lahore, Pakistan
Maha Maqsood
Department of Zoology, Lahore College for Women University, Lahore, Pakistan
Shagufta Naz
Department of Zoology, Lahore College for Women University, Lahore, Pakistan
Farkhanda Manzoor
Department of Zoology, Lahore College for Women University, Lahore, Pakistan
Shahjahan
University of Health Sciences, Lahore, Pakistan
Tasnim Farasat
Department of Zoology, Lahore College for Women University, Lahore, Pakistan

ABSTRAKT

Type 2 diabetes mellitus (T2DM) is the most common metabolic and multifactorial disease in which both genetic and environmental factors are involved. In diabetes, the defects in the cellular metabolism result in higher levels of free radicals. These radicals react with other vital cellular molecules, which are responsible in diabetes side effects and known as diabetic retinopathy (DR), a disease of the retina that results in impairment or loss of vision. In the present study, we investigated the expression of glutathione S-transferases class theta 1 (GSTT1) in type 2 DR subjects. Highly significant differences (P ≤ 0.05) were observed in GSST1 expression in DR patients compared with diabetic and control groups.