Erscheint 6 Ausgaben pro Jahr
ISSN Druckformat: 1045-4403
ISSN Online: 2162-6502
Indexed in
Therapeutic Intervention with Breast Cancer Metastasis
ABSTRAKT
Metastatic disease, mainly to the lungs, liver, bone, and brain, is the most common cause of death from breast cancer, despite advances in surgical and clinical management. Two basic principles govern the process of metastasis. First, that tumors are heterogeneous populations of cells, and second, that the process is a sequence of events that depends on tumor cell properties and interactions with the microenvironment at the site of metastasis. Inhibitors targeted at any of these different steps have the potential to inhibit metastatic progression, and examples of key therapeutic targets include overexpression of growth factor receptors, angiogenic factors, matrix metalloproteases, and integrin receptors. The identification of molecular targets for therapy of breast cancer metastasis will be accelerated by DNA array technology, and their selection for use should include evaluation of interactions between tumor cells and normal tissue components. These sorts of inhibitors are likely to target both cancer and normal cell functions, for example, inhibitors of matrix metalloproteases that can potentially inhibit both tumor cell invasion and angiogenesis. The use of appropriate animal models will be necessary to determine the impact of targeted inhibitors on the growth and development of breast cancer metastasis.
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Rabbani Shafaat A., Mazar Andrew P., Evaluating distant metastases in breast cancer: from biology to outcomes, Cancer and Metastasis Reviews, 26, 3-4, 2007. Crossref
-
Dréau Didier, Karaa Amel, Culberson Cathy, Wyan Heather, McKillop Iain H., Clemens Mark G., Bosentan® inhibits tumor vascularization and bone metastasis in an immunocompetent skin-fold chamber model of breast carcinoma cell metastasis, Clinical & Experimental Metastasis, 23, 1, 2006. Crossref
-
Zhao Caijie, Cai Mi, Zhang Yao, Liu Ying, Sun Ronghua, Zhang Ning, Development of a microscopy-based assay for protein kinase Cζ activation in human breast cancer cells, Analytical Biochemistry, 362, 1, 2007. Crossref
-
Clines Gregory A., Chirgwin John M., Guise Theresa A., Skeletal Complications of Malignancy: Central Role for the Osteoclast, in Bone Resorption, 2, 2005. Crossref
-
Parker Belinda S., Eckhardt Bedrich L., Anderson Robin L., Models of Breast Cancer Metastasis to Bone: Characterization of a Clinically Relevant Model, in Bone Metastasis and Molecular Mechanisms, 6, 2004. Crossref
-
Chhichholiya Yogita, Suman Prabhat, Singh Sandeep, Munshi Anjana, The genomic architecture of metastasis in breast cancer: focus on mechanistic aspects, signalling pathways and therapeutic strategies, Medical Oncology, 38, 8, 2021. Crossref