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Critical Reviews™ in Eukaryotic Gene Expression
Impact-faktor: 2.156 5-jähriger Impact-Faktor: 2.255 SJR: 0.649 SNIP: 0.599 CiteScore™: 3

ISSN Druckformat: 1045-4403
ISSN Online: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukaryotGeneExpr.2015012447
pages 41-46

NPR-A: A Therapeutic Target in Inflammation and Cancer

Jia Zhang
Department of Thoracic Surgery, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, China
Min Li
Department of Surgical Oncology, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, China
Ya Yang
Department of Surgical Oncology, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, China
Yan Yan
Department of Surgical Oncology, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China
Junhai Li
Department of Surgical Oncology, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China; Department of Thoracic Surgery, the Nucleus Industry 215 Hospital, Xianyang, China
Jingkun Qu
Department of Surgical Oncology, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China
Jiansheng Wang
Tianjin University

ABSTRAKT

Natriuretic peptide receptor A (NPR-A) is the receptor for atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP). NPR-A plays critical physiological and pathophysiological roles in several target cell and tissue system processes, such as cell growth, apoptosis, proliferation, and inflammation. Accumulating data demonstrate that NPR-A is involved in immune and inflammatory reactions and is a potential target in inflammation treatment. It is expressed in various cancer cells and is important for tumor growth. A recent study indicated that NPR-A signaling can regulate stem cell recruitment and angiogenesis. This signaling can serve as a model for studying the linkage between inflammation and tumorigenesis. In this review we highlight the mechanisms by which NPR-A affects signaling pathways involved in inflammation and cancer, and we discuss its potential as a novel target in inflammation, cancer, and cancer-related inflammation.


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