Erscheint 6 Ausgaben pro Jahr
ISSN Druckformat: 1045-4403
ISSN Online: 2162-6502
IF:
1.6
5-Year IF:
2.2
Immediacy Index:
0.3
Eigenfactor:
0.00058
JCI:
0.33
SJR:
0.345
SNIP:
0.46
CiteScore™::
2.5
H-Index:
67
Indexed in
Role of Autophagy in Photoreceptor Cell Survival and Death
Get access
ABSTRAKT
Autophagy, a highly conserved self-degradation process that occurs under both physiological and pathological conditions, provides the raw material and energy for cell regeneration under normal circumstances. Dysregulated autophagy under diseased conditions may cause protein accumulation, organelle dysfunction, and even cell death. Recent studies have shown that autophagy regulates the structural integrity and physiological functions of retinal photoreceptor cells and contributes to the pathogenesis of retinopathies such as retinal detachment, age-related macular degeneration, retinitis pigmentosa, and Leber's congenital amaurosis. In this review, we discuss the role of autophagy in photoreceptor cell survival and death in retinal physiology and diseases, and suggest the possibility that autophagy-targeting therapy may be a new strategy for retinal diseases marked by photoreceptor cell death.
-
Miao Xu-Dong, Cao Le, Zhang Qiang, Hu Xiao-Ying, Zhang Yi, Effect of PI3K-mediated autophagy in human osteosarcoma MG63 cells on sensitivity to chemotherapy with cisplatin, Asian Pacific Journal of Tropical Medicine, 8, 9, 2015. Crossref
-
Hasegawa Tomoko, Ikeda Hanako O., Nakano Noriko, Muraoka Yuki, Tsuruyama Tatsuaki, Okamoto-Furuta Keiko, Kohda Haruyasu, Yoshimura Nagahisa, Changes in morphology and visual function over time in mouse models of retinal degeneration: an SD-OCT, histology, and electroretinography study, Japanese Journal of Ophthalmology, 60, 2, 2016. Crossref
-
Li Junyang, Tang Chao, Li Liwen, Li Rujun, Fan Youwu, Quercetin blocks t-AUCB-induced autophagy by Hsp27 and Atg7 inhibition in glioblastoma cells in vitro, Journal of Neuro-Oncology, 129, 1, 2016. Crossref
-
Yao Jiaqi, Ma Chi, Gao Wei, Liang Jinxiao, Liu Chang, Yang Hongfang, Yan Qiu, Wen Qingping, Fentanyl induces autophagy via activation of the ROS/MAPK pathway and reduces the sensitivity of cisplatin in lung cancer cells, Oncology Reports, 36, 6, 2016. Crossref
-
Ankita , Saxena Sandeep, Nim Dwividendra K., Stefanickova Jana, Ziak Peter, Stefanicka Patrik, Kruzliak Peter, Retinal photoreceptor apoptosis is associated with impaired serum ionized calcium homeostasis in diabetic retinopathy: An in-vivo analysis, Journal of Diabetes and its Complications, 33, 3, 2019. Crossref
-
Chang Chih-Chao, Huang Tien-Yi, Chen Hsin-Yuan, Huang Tsui-Chin, Lin Li-Chun, Chang Yen-Jui, Hsia Shih-Min, Protective Effect of Melatonin against Oxidative Stress-Induced Apoptosis and Enhanced Autophagy in Human Retinal Pigment Epithelium Cells, Oxidative Medicine and Cellular Longevity, 2018, 2018. Crossref
-
Donato Luigi, Scimone Concetta, Nicocia Giacomo, D’Angelo Rosalia, Sidoti Antonina, RETRACTED ARTICLE: Role of oxidative stress in Retinitis pigmentosa: new involved pathways by an RNA-Seq analysis, Cell Cycle, 18, 1, 2019. Crossref
-
Charish Jason, cAMP and Photoreceptor Cell Death in Retinal Degeneration, in Retinal Degenerative Diseases, 1185, 2019. Crossref
-
Santo Manuela, Conte Ivan, Emerging Lysosomal Functions for Photoreceptor Cell Homeostasis and Survival, Cells, 11, 1, 2021. Crossref
-
Zhang Kexiang, Wu Song, Wu Hongwei, Liu Li, Zhou Jiahui, Effect of the Notch1-mediated PI3K-Akt-mTOR pathway in human osteosarcoma, Aging, 13, 17, 2021. Crossref
-
Niu Rui, Wang Jindan, Geng Chao, Li Yahong, Dong Lijie, Liu Lin, Chang Yuwen, Shen Jianqun, Nie Zetong, Zhang Yan, Hu Bojie, Tandem mass tag-based proteomic analysis reveals cathepsin-mediated anti-autophagic and pro-apoptotic effects under proliferative diabetic retinopathy, Aging, 13, 1, 2021. Crossref
-
Hasegawa Tomoko, Ikeda Hanako Ohashi, Iwai Sachiko, Muraoka Yuki, Tsuruyama Tatsuaki, Okamoto-Furuta Keiko, Kohda Haruyasu, Kakizuka Akira, Yoshimura Nagahisa, Branched chain amino acids attenuate major pathologies in mouse models of retinal degeneration and glaucoma, Heliyon, 4, 2, 2018. Crossref