Abo Bibliothek: Guest
Digitales Portal Digitale Bibliothek eBooks Zeitschriften Referenzen und Berichte Forschungssammlungen
Critical Reviews™ in Eukaryotic Gene Expression
Impact-faktor: 2.156 5-jähriger Impact-Faktor: 2.255 SJR: 0.649 SNIP: 0.599 CiteScore™: 3

ISSN Druckformat: 1045-4403
ISSN Online: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v6.i1.40
pages 59-73

Novel Systems for Controlled Delivery of Macromolecules

Patricia Y. P. Kuo
Department of Chemical Engineering, The Johns Hopkins University, Baltimore, MD 21218
W. Mark Saltzman
Department of Chemical Engineering, The Johns Hopkins University, Baltimore, MD 21218

ABSTRAKT

Gene therapy promises new treatments for human disease by alterations in the DNA content of tissues. Methods for efficient and stable introduction of genes into target cells in the body are critically important in this effort. Researchers and physicians now have many years of experience with synthetic polymers for controlled drug delivery; many of these polymers can also be used to deliver macromolecules at controlled rates to tissues. This article reviews the use of polymers in controlled protein delivery and suggests ways that polymer delivery systems may be useful in the delivery of gene transfer agents.


Articles with similar content:

A Review of the Application of Lipid-Based Systems in Systemic, Dermal/ Transdermal, and Ocular Drug Delivery
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.25, 2008, issue 6
Kishor M. Wasan, Pavel Gershkovich, Cheri A. Barta
Approaches to Oral Drug Delivery for Challenging Molecules
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.23, 2006, issue 2
Steven M. Dinh, Gabriela Mustata
Factors Affecting Drug and Gene Delivery: Effects of Interaction with Blood Components
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.19, 2002, issue 3
Makiya Nishikawa, Mitsuru Hashida, Praneet Opanasopit
Oral Delivery of Proteins: Progress and Prognostication
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.19, 2002, issue 2
Fakhrul Ahsan, Mansoor A. Khan, Rakhi B. Shah
Lipoproteins: From Physiological Roles to Drug Delivery Potentials
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.23, 2006, issue 6
Abdolhossein Zarrin, Mehrdad Hamidi, Mahshid Foroozesh