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Critical Reviews™ in Eukaryotic Gene Expression
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ISSN Druckformat: 1045-4403
ISSN Online: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v4.i2-3.30
pages 345-355

Expression of the BMP 2 Gene during Bone Cell Differentiation

Nandini Ghosh-Choudhury
University of Texas Health Science Center at San Antonio, Department of Medicine, Division of Endocrinology and Metabolism, San Antonio, TX 78284-7877
Marie A. Harris
University of Texas Health Science Center at San Antonio, Department of Medicine, Division of Endocrinology and Metabolism, San Antonio, TX 78284-7877
Jian Q. Feng
University of Texas Health Science Center at San Antonio, Department of Medicine, Division of Endocrinology and Metabolism, San Antonio, TX 78284-7877
Gregory R. Mundy
Division of Endocrinology, Department of Medicine, University of Texas Health Science Center, San Antonio, TX
Stephen E. Harris
University of Texas Health Science Center at San Antonio, Department of Medicine, Division of Endocrinology and Metabolism, San Antonio, TX 78284-7877

ABSTRAKT

Bone morphogenetic protein 2 (BMP 2) and transforming growth factor β (TGFβ) are actively involved in bone formation and remodeling. TGFβ, a powerful stimulant in the early stage of bone cell growth and matrix formation, inhibits differentiation and in vitro mineralized nodule formation in primary fetal rat calvarial osteoblast system. TGFβ also negatively regulates BMP 2 expression at the transcriptional level. BMP 2 gene expression is controlled by a battery of transcriptional factors, some known and some yet to be identified. Immortalized osteoblast cell lines generated from a transgenic mouse carrying BMP 2 promoter-driven SV40 large T antigen transgene are described as powerful tools for studying regulation of BMP 2 gene expression and bone cell differentiation at the molecular level.


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