Abo Bibliothek: Guest
Digitales Portal Digitale Bibliothek eBooks Zeitschriften Referenzen und Berichte Forschungssammlungen
Critical Reviews™ in Eukaryotic Gene Expression
Impact-faktor: 1.841 5-jähriger Impact-Faktor: 1.927 SJR: 0.649 SNIP: 0.516 CiteScore™: 1.96

ISSN Druckformat: 1045-4403
ISSN Online: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukaryotGeneExpr.2016015964
pages 137-142

The Impacts of miRNAs in Glioblastoma Progression

Rasime Kalkan
Near East University, Faculty of Medicine, Department of Medical Genetics, Cyprus
Emine İkbal Atli
Department of Medical Genetics, Faculty of Medicine, Trakya University, Edirne, Turkey

ABSTRAKT

miRNAs are short noncoding RNA sequences that cause translational repression or mRNA degradation. A growing number of studies have sought new biomarkers in GBM that will be important in disease progression and prognosis and as potential therapeutic targets. miRNA-profiling studies in glioblastoma patients have found that aberrant miRNA expression can be used as a target to develop new biomarkers for disease detection and for determining prognosis or therapeutic response. In evaluating the tumor or its therapeutic response, genetic abnormalities such as mutations, epigenetic abnormalities, and aberrant miRNA expressions can be useful markers. This review summarizes the known miRNAs according their therapeutic importance and their use as disease progression biomarkers.

SCHLÜSSELWÖRTER: miRNA, GBM, Glioblastoma, therapy, survival

Articles with similar content:

MicroRNAs as Diagnostic, Prognostic, and Therapeutic Biomarkers in Prostate Cancer
Critical Reviews™ in Eukaryotic Gene Expression, Vol.29, 2019, issue 2
Faezeh Ghasemi, Atefeh Amiri, Hamed Mirzaei, Aria Masoudifar, Reza Salarinia, Arad Mobasher Aghdam
Molecular Mechanisms Underlying the Role of MicroRNAs in Resistance to Epidermal Growth Factor Receptor-Targeted Agents and Novel Therapeutic Strategies for Treatment of Non-Small-Cell Lung Cancer
Critical Reviews™ in Oncogenesis, Vol.18, 2013, issue 4
Elena Galvani, Godefridus J. Peters, Mina Maftouh, Elisa Giovannetti, Amir Avan
DLK1-MEG3 Imprinted Domain MicroRNAs in Cancer Biology
Critical Reviews™ in Eukaryotic Gene Expression, Vol.22, 2012, issue 1
George Vartholomatos, Evangelos Voulgaris, Leonidas Benetatos
The Oncogenic Role of Yin Yang 1
Critical Reviews™ in Oncogenesis, Vol.16, 2011, issue 3-4
Daniel B. Stovall, Guangchao Sui, Kazushi Inoue, Qiang Zhang
SNPs in MicroRNA Binding Sites as Prognostic and Predictive Cancer Biomarkers
Critical Reviews™ in Oncogenesis, Vol.18, 2013, issue 4
Joanne B. Weidhaas, Carina Preskill