Erscheint 6 Ausgaben pro Jahr
ISSN Druckformat: 1045-4403
ISSN Online: 2162-6502
Indexed in
Mini-Review on Cachexia-Related miRNA
ABSTRAKT
Cachexia, or muscle wasting, is a complex metabolic syndrome associated with an underlying illness and characterized by loss of muscle mass. It is a rather prevalent condition, with impacts on patient survival, response to treatment, and quality of life. Treatment options are sparse because of cachexia's multifactorial pathogenesis. Recently, attention has focused on microRNAs (miRNAs) as potential therapeutic targets of several diseases. miRNAs are small, 18- to 25-base-long constructs that regulate gene expression on a post-transcriptional level, selectively activating or repressing elements of specific signaling pathways. In this review, we investigated whether miRNAs play any role in cachexia's biochemical pathways and if miRNA targeting has any significant impact on preclinical models of cachexia.
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Powrózek Tomasz, Brzozowska Anna, Mazurek Marcin, Mlak Radosław, Sobieszek Grzegorz, Małecka‐Massalska Teresa, Combined analysis of miRNA‐181a with phase angle derived from bioelectrical impedance predicts radiotherapy‐induced changes in body composition and survival of male patients with head and neck cancer, Head & Neck, 41, 9, 2019. Crossref
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Xu Zhishan, Guo Bingyu, Chang Peng, Hui Qiang, Li Wei, Tao Kai, The Differential Expression of miRNAs and a Preliminary Study on the Mechanism of miR-194-3p in Keloids, BioMed Research International, 2019, 2019. Crossref