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Critical Reviews™ in Eukaryotic Gene Expression
Impact-faktor: 2.156 5-jähriger Impact-Faktor: 2.255 SJR: 0.649 SNIP: 0.599 CiteScore™: 3

ISSN Druckformat: 1045-4403
ISSN Online: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukaryotGeneExpr.2014007569
pages 29-38

The Different Molecular Mechanisms of Mitophagy Between Yeast and Mammals

Ying Song
Department of Pharmacology, Zhejiang University of Technology, 18# Chaowang Road, Hangzhou City, Zhejiang Province 310014, P.R. China
Yan Xiao
Department of Pharmacology, Zhejiang University of Technology, Hangzhou Chaowang Road 18#, Zhejiang, 310014, P.R. China
Jia-Ming Wang
Department of Life Sciences Beking University , Yiheyuan Road 5#, Haidian District, Beijing, 100871, P.R. China
Qi Chen
Third hospital of Hangzhou, West Lake Road 38#, 310016, P.R. China


The mitochondrion is the site of energy metabolism inside the cell; which produces ATP for vital activities. The accumulation of damaged mitochondria affects cell survival, these organelles are removed via mitophagy to maintain cell vitality. Currently, mitophagy is a hot topic in life science research. Understanding the role of mitophagy in pathogenesis and its association with the genesis of disease is important for developing treatments for many human diseases. Here, we summarize current progress in the study of mitophagy and describe the different molecular mechanisms of mitophagy between yeast and mammals, as well as related diseases.

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