Abo Bibliothek: Guest
Digitales Portal Digitale Bibliothek eBooks Zeitschriften Referenzen und Berichte Forschungssammlungen
Critical Reviews™ in Eukaryotic Gene Expression
Impact-faktor: 1.734 5-jähriger Impact-Faktor: 1.848 SJR: 0.627 SNIP: 0.516 CiteScore™: 1.96

ISSN Druckformat: 1045-4403
ISSN Online: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v9.i3-4.220
pages 373-381

Rules to Remodel By: What Drives Nuclear Envelope Disassembly and Reassembly during Mitosis?

Spyros D. Georgatos
Dept. of Basic Sciences, University of Crete, School of Medicine, 71 110 Heraklion, Crete, Greece
Panayiotis A. Theodoropoulos
Dept. of Basic Sciences, University of Crete, School of Medicine, 71 110 Heraklion, Crete, Greece

ABSTRAKT

In higher eukaryotic cells the nuclear envelope is reversibly disassembled during mitosis. Under in vivo conditions this process occurs in a sequential, stepwise fashion and involves a variety of structural intermediates. Here we discuss the topological features of these intermediates and their transient interactions with chromatin and the cytoskeleton. As it becomes apparent, nuclear envelope disassembly and reassembly are regulated at multiple levels by modulating the affinity of protein-protein interactions, limiting the availability of structural subunits in different areas of the mitotic cytoplasm, and redirecting mechanical forces exerted by the microtubules.


Articles with similar content:

The Nucleosomal Array: Structure/Function Relationships
Critical Reviews™ in Eukaryotic Gene Expression, Vol.6, 1996, issue 2-3
Jeffrey C. Hansen, Terace M. Fletcher
Mechanosensing and Mechanochemical Transduction: How Is Mechanical Energy Sensed and Converted Into Chemical Energy in an Extracellular Matrix?
Critical Reviews™ in Biomedical Engineering, Vol.31, 2003, issue 4
Lorraine M. Siperko, Frederick H. Silver
The Intertwining of Structure and Function: Proposed Helix-Swapping of the SH2 Domain of Grb7, A Regulatory Protein Implicated in Cancer Progression and Inflammation
Critical Reviews™ in Immunology, Vol.30, 2010, issue 3
Sally Pias, Dennis L. Johnson, Barbara A. Lyons, Tabitha A. Peterson
Parameters of LRP5 from a Structural and Molecular Perspective
Critical Reviews™ in Eukaryotic Gene Expression, Vol.15, 2005, issue 3
Mark L. Johnson, Douglas T. Summerfield
Coactivation and Corepression in Transcriptional Regulation by Steroid/Nuclear Hormone Receptors
Critical Reviews™ in Eukaryotic Gene Expression, Vol.8, 1998, issue 2
J. Don Chen, Hui Li