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Critical Reviews™ in Eukaryotic Gene Expression
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ISSN Druckformat: 1045-4403
ISSN Online: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v9.i3-4.30
pages 183-190

Interrelationships of Transcriptional Machinery with Nuclear Architecture

Gary Stein
University of Vermont
Andre J. van Wijnen
Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, MA 01655
Janet L. Stein
Department of Biochemistry, University of Vermont 89 Beaumont Ave., Given E210E Burlington, VT 05405
Jane B. Lian
Department of Biochemistry University of Vermont 89 Beaumont Ave., Given E210B Burlington, VT 05405

ABSTRAKT

There is increasing evidence for functional linkages between nuclear architecture and the regulation of gene expression. The nuclear matrix provides a paradigm for involvement of nuclear morphology in assembly of the biochemical machinery for physiological control of transcription. Mechanisms are being experimentally defined that direct regulatory factors to subnuclear sites that support gene expression. Consequently, we are gaining insight into the rules that govern transcriptional control within the three-dimensional context of nuclear organization.


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