Abo Bibliothek: Guest
Digitales Portal Digitale Bibliothek eBooks Zeitschriften Referenzen und Berichte Forschungssammlungen
International Journal of Physiology and Pathophysiology
SJR: 0.116

ISSN Druckformat: 2155-014X
ISSN Online: 2155-0158

Archives: Volume 1, 2010 to Volume 9, 2018

International Journal of Physiology and Pathophysiology

DOI: 10.1615/IntJPhysPathophys.v7.i3.70
pages 247-253

The Ways of Lipid Peroxidation and Protein Activation in Chronic Kidney Disease

Lesya V. Korol
Institute of Nephrology, National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine


We studied spontaneous and metal-induced oxidation of lipids and proteins in in vitro modeling of the pathways of lipid peroxidation from the formation of malondialdehyde (MDA) and protein carbonyl groups (PCG) in 86 patients with chronic pyelonephritis (CPN) and 64 patients suffering from chronic glomerulonephritis (CGN) without disturbing the excretory function of the kidneys. It has been found that the MDA content in the blood serum of patients with CPN and CGN increases 2 and 2.3 times, respectively, compared to that in a group of practically healthy individuals. In erythrocytes of CPN and CGN, MDA content grows by 14%, and 29%, respectively; PCG content increases 1.5 and 2 times. Patients with CGN demonstrate more pronounced increase in both MDA and PCG content in the blood. Stimulation in vitro of lipid peroxidation processes contributes much to the growth of these indicators compared to the baseline prior to stimulation. When modeling in vitro ascorbate- and NADPH-dependent pathways of lipid and protein peroxidation, an increase in MDA and PCG production in both groups of patients, especially in the second pathway, are observed, which should be taken into account in the correction of oxidative processes and antioxidant treatment.

Articles with similar content:

Induction of Oxidative and Nitrosative Stress in Young Males in Adapting to Muscular Load during Training and Competitive Periods
International Journal of Physiology and Pathophysiology, Vol.8, 2017, issue 2
Anastasiia V. Symonik, Anatoliy V. Kotsuruba, Nadiia V. Bogdanovs'ka
Target Correction of Mitochondrial Dysfunction in Parkinson's Disease by Capicor
International Journal of Physiology and Pathophysiology, Vol.9, 2018, issue 4
Nina V. Karasevich, Larisa. V. Bratus, Kateryna V. Rosova, Ivan D. Glazyrin, Iryna M. Mankovska, Iryna M. Karaban, Valentina I. Nosar, Tetyana I. Drevitska, Olga O. Gonchar
Effects of Aegle marmelos (L.) Correa on the Peripheral Blood and Small Intestine of Mice Exposed to Gamma Radiation
Journal of Environmental Pathology, Toxicology and Oncology, Vol.25, 2006, issue 4
Ponemone Venkatesh, Parampally Archana, Ganesh Chandra Jagetia, Manjeshwar Shrinath Baliga, Bhandarkar R. Krishnanand
Hormonal Changes in Female Rats Exposed to Chronic Stress and Androgen Excess at Pubescence
International Journal of Physiology and Pathophysiology, Vol.4, 2013, issue 1
Olga V. Sachynska, I. Yu. Ganzhiy, Nadiya D. Nosenko, Larisa V. Tarasenko, Pyotr V Sinitsyn, Alexander G. Reznikov
Effect of Chronic Postnatal Stress on Pro-and Antioxidant System and Changes in Autonomic Balance of Cardiac Rhythm in Rats
International Journal of Physiology and Pathophysiology, Vol.9, 2018, issue 3
Iryna R. Mits, Olha V. Denefil