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ISSN Druckformat: 2155-014X
ISSN Online: 2155-0158
Effect of Probiotic Therapy on the Experimental Obesity Development in Rats Caused by Monosodium Glutamate
ABSTRAKT
The effect of the probiotic strains mixture (2:1:1 Lactobacillus casei IMVB-7280, Bifidobacterium animalis VKL, Bifidobacterium animalis VKB) on the experimental obesity development induced by neonatal administration of monosodium glutamate was studied in rats. It has been shown that the four-month old rats injected with monosodium glutamate just after birth (4 mg/g, on the 2nd ,4th, 6th, 8th and the10th days) had an abdominal obesity and metabolic syndrome. Intermittent administration of a probiotic mixture to rats subjected to monosodium glutamate (MSG) in the neonatal period prevented obesity development. In the group of rats treated with probiotics, anthropometric parameters (weight and body length, Lee index, body mass index) did not differ from the level in intact rats. Visceral fat mass was decreased by probiotics by 38.5% (P < 0.05) compared to rats treated with water. Probiotics improved lipid metabolism: reduced the level of very low density lipoprotein (VLDL) by 32.2% (P < 0.05), low density lipoprotein (LDL) level by 30.6% (P < 0.05), and increased the level of high density lipoprotein (HDL) by 25.7% (P < 0.05) compared to obese control rats. Probiotic strains restored the secretion of adipocytes hormones (leptin and adiponectin) to the normal level in intact animals. The results obtained show the effectiveness of probiotics for the prevention of obesity.