Abo Bibliothek: Guest
International Journal of Physiology and Pathophysiology

Erscheint 4 Ausgaben pro Jahr

ISSN Druckformat: 2155-014X

ISSN Online: 2155-0158

SJR: 0.116

Continuous Adaptation of Rats to Hypobaric Hypoxia Prevents Stressor Hyperglycemia and Optimizes Mitochondrial Respiration in Acute Hypoxia

Volumen 4, Ausgabe 2, 2013, pp. 137-147
DOI: 10.1615/IntJPhysPathophys.v4.i2.60
Get accessGet access

ABSTRAKT

Oxygen consumption, glucose level in the blood, and respiration of the liver mitochondria were investigated in male Wistar rats, permanently living in middle altitude (2100 m, Elbrus region). The animals were characterized by reduced oxygen consumption and blood glucose level, as well as by intensified utilization of NAD-dependent substrates in mitochondrial respiratory chain and increased indices of ADP-stimulated respiration, in comparison with rats residing in the low land. As a result of adaptive rebuilding of oxidative metabolism in those rats residing in the midland, the nature and severity of metabolic responses to acute hypoxia were also changed. An exposure of the rats residing in the lowland to barochamber on the "altitude" 5600 m for 3 hours resulted in both transient hypometabolic reaction, and a stressor hyperglycemic one. Rapid adaptation of mitochondrial function occurred due to an increase in the rate of PAD-dependent substrate oxidation accompanied by a decrease in the effectiveness of phosphorylation. In midland rats, by contrast, hypoglycemic reaction was developed, and further reduction of aerobic metabolism was limited. Rapid adaptation of mitochondrial function to acute hypoxia in those rats was more intense than in the low land animals. This was achieved by a significant increase in the rate of NAD-dependent substrate oxidation, especially lipids, and an improved efficiency of mitochondrial respiration and an increased economy of oxygen utilization.

888 Artikelansichten 4 Artikel-Downloads Metriken
888 ANSICHTEN 4 HERUNTERLADEN Google
Scholar
ZITATE

Artikel mit ähnlichem Inhalt:

The Effect of Lomg-Term Exercise Training on the Changes in the Functional State of Heart duringIschemia-Reperfusion, the Sensitivity of Calcium- Induced Mitochondrial Permeability Transition Pore and the Uncoupling Protein 3 Expression International Journal of Physiology and Pathophysiology, Vol.1, 2010, issue 3
Snizhana V. Chorna, Nataliya A. Strutynska, Galyna L. Vavilova, Vadim F. Sagach, N. M. Gaidai, Sergiy O. Talanov
Mitochondrial Membrane Potential and Oxygen Consumption in Spontaneously Hypertensive Rats International Journal of Physiology and Pathophysiology, Vol.3, 2012, issue 1
Yulia V. Goshovska, Vadim F. Sagach, Nataliya A. Dorofeyeva
Hydrogen Sulfide Inhibits Calcium-Induced Mitochondrial Permeability Transition Pore Opening in the Heart of Spontaneously Hypertensive Rats International Journal of Physiology and Pathophysiology, Vol.4, 2013, issue 4
Nataliya A. Strutynska, Galyna L. Vavilova, Vadim F. Sagach, Nataliya A. Dorofeyeva
Activation of Endogenous Hydrogen Sulfide Synthesis Inhibits Mitochondrial Permeability Transition Pore Opening and Restores Constitutive NO-Synthase Coupling in Old Rat Heart International Journal of Physiology and Pathophysiology, Vol.9, 2018, issue 1
Nataliya A. Strutynska, V. R. Strutynskyi, Lidiya A. Mys, Vadim F. Sagach
Mechanisms of Phase Changes in Energy Metabolism at Adaptation to Immobilization Stress: Role of Corticosterone International Journal of Physiology and Pathophysiology, Vol.6, 2015, issue 4
Volodymyr I. Portnichenko, Anna V. Opanasenko, Valentina I. Nosar, Irina N. Mankovskaya, Olga A. Gonchar

Neueste Ausgabe

Systemic Toxic Dental Sealant-Induced Effect on Nervous Tissue in vitro O. A. Znachkova, Irina V. Lushnikova, Galina G. Skibo, M. Y. Antonenko, Nana V. Voitenko Impact of Various Polyphenols on Disturbance of Cholesterol Metabolism under Insulin Resistance V. P. Fylymonenko, A. L. Zagayko Target Correction of Mitochondrial Dysfunction in Parkinson's Disease by Capicor Iryna M. Mankovska, Kateryna V. Rosova, Olga O. Gonchar, Valentina I. Nosar, Larisa. V. Bratus, Tetyana I. Drevitska, Ivan D. Glazyrin, Nina V. Karasevich, Iryna M. Karaban Changes in Ongoing Activity and Electrophysiological Characteristics of the Rat Retinal Ganglion Cells in Diabetes Mellitus N. Ya. Martyniuk, V. Yu. Maslov, Helen E. Purnyn, Svetlana A. Fedulova, Nikolai S. Veselovsky Sex Characteristics of Hydrogen Sulfide Effect on Ischemia-Reperfusion in Rat Myocardium Andrii V. Melnyk, Nataliia V. Zaichko, Oleksii A. Khodakovskyi, Olga V. Khodakivska Cardiohemodynamic Changes in Focal Cerebral Ischemia Roman R. Sharipov, Nataliya A. Dorofeyeva, Vadim F. Sagach Cerebral Hemodynamics and Electroencephalographic Pattern in Patients with Symptomatic Epilepsy at Combined Treatment with Transcranial Direct Current Stimulation Kateryna V. Yatsenko Physiological Endurance of Skeletal Muscle Increases under C60 Fullerene Application before Physical Load Tetyana Yu. Matvienko, Danylo Zavodovskiy, Iryna V. Mishchenko, Kateryna I. Bogutska, Yuriy I. Prylutskyy, Sofia Paradizova, Larisa Bezuh, Uwe Ritter, Peter Scharff Possible Mechanisms Underlying Association between Thyroiditis and Thyroid Papillary Carcinoma Tamara M. Myshunina, Mykola D. Tronko Index, Volume 9, 2018
Digitales Portal Digitale Bibliothek eBooks Zeitschriften Referenzen und Berichte Forschungssammlungen Preise und Aborichtlinien Begell House Kontakt Language English 中文 Русский Português German French Spain