ABSTRAKT

The effects of prolonged immobilization (6 h strict horizontal position of rats in the tight containers daily for 2 weeks) on oxygen tension in the gingival tissue, oxygen consumption by the mandible alveolar bone, pro-/antioxidant balance and energetic metabolism of soft periodontal tissues were investigated. It has been shown that prolonged immobilization stress results in a marked decrease in the gingival tissue PO₂ (by 36%), oxygen consumption rate in the bone tissue (by 46%), and a reduction in the gingival mitochondrial respiration rate, compared to the control values. The latter is more significantly manifested in case of oxidation of α-ketoglutarate, NAD-dependent substrate of the respiratory chain, compared to succinate, FAD-dependent one. The prolonged stress results in intensification of peroxide processes and a depletion of antioxidant protection of the soft periodontal tissues. It has been found that pharmacological drugs Thiotriazolin and Actovegin possess modifying protective effect on stress-induced disorders of oxygen homeostasis in the soft and hard periodontal tissues under prolonged immobilization stress.