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International Journal of Physiology and Pathophysiology
SJR: 0.116

ISSN Druckformat: 2155-014X
ISSN Online: 2155-0158

Archives: Volume 1, 2010 to Volume 9, 2018

International Journal of Physiology and Pathophysiology

DOI: 10.1615/IntJPhysPathophys.v8.i2.20
pages 111-119

Comparative Analysis of Apoptotic Processes in Some Areas of the Cerebral Cortex in Experimental Ischemia-Reperfusion against the Background of Diabetes Mellitus

Taras M. Boychuk
Higher State Educational Establishment of Ukraine "Bukovinian State Medical University," Chernivtsi, Ukraine
Taras I. Kmet
Bukovinian State Medical University, Chernivtsi, Ukraine

ABSTRAKT

The effects of diabetes mellitus (DM) on the dynamics and intensity of neuronal and glial apoptosis were studied in the frontal, parietal and temporal lobes of the cerebral cortex of rats after ischemia-reperfusion injury. In control animals (without diabetes mellitus), the level of apoptotic processes in neurons and gliocytes has been found to be unchanged in the frontal cortex after 20 minutes of carotid ischemia with one-hour reperfusion, whereas in the parietal lobe apoptosis was activated in neuronal cells, and in the temporal lobe, it was activated in both neuronal and glial cells. Three-month-long diabetes mellitus enhanced apoptotic cell death in neurons and glial cells of the frontal and temporal lobes of the cortex. In the parietal lobe, apoptosis increased only in neurons, but it decreased in glial cells. In early ischemic-reperfusion period, the activity of apoptotic processes in the frontal and temporal lobes of the cortex remained unchanged in animals with diabetes mellitus, but it decreased in the parietal lobe on account of the glial cells. On the 12th day of observation, the activity of apoptotic processes in the temporal lobe of control rats increased in neurocytes and decreased in the glial cells. In the frontal and parietal lobes of the cortex, the latter decreased only in glial cells. In neurons, reduced content of the protein p53 was observed against the background of increasing density of p53+-cells. In this period of observation, the activity of apoptotic processes in rats with diabetes mellitus decreased generally both in neurons and glial cells of all the cerebral cortex areas under study. The results obtained, on the one hand, indicate the availability of regional differences in the dynamics of the response of cerebral cortex lobes examined to ischemic-reperfusion lesion as evidenced by the intensity of apoptotic processes in the neurons and glial cells, and, on the other hand, a modified effect of diabetes mellitus on the indices studied.


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