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International Journal of Physiology and Pathophysiology
SJR: 0.106

ISSN Druckformat: 2155-014X
ISSN Online: 2155-0158

Archives: Volume 1, 2010 to Volume 9, 2018

International Journal of Physiology and Pathophysiology

DOI: 10.1615/IntJPhysPathophys.v6.i4.10
pages 269-276

Peculiarities of Effects of Nonsteroidal Anti-inflammatory Drugs on NO-synthase System in Gastric Mucosa of Rats under Stress Conditions

I. S. Fomenko
Danila Galytsky National Medical University, Lviv, Ukraine
T. I. Bondarchuk
Danila Galytsky National Medical University, Lviv, Ukraine
L. P. Biletska
Danila Galytsky National Medical University, Lviv, Ukraine
N. B. Panasyuk
Danila Galytsky National Medical University, Lviv, Ukraine
Oleksandr Ya. Sklyarov
Danylo Halytsky Lviv National Medical University, Lviv, Ukraine

ABSTRAKT

In experiments on rats with immobilization stress combined with water immersion, effects of nonsteroidal anti-inflammatory drugs (NSAIDs) of different genesis on the morphological status of gastric mucosa and changes in NO-synthase system activity were studied. An administration of naproxen, noncelective cyclooxygenase inhibitor, to rats with water-restrained stress enhanced strucrural hemorrhagic gastric mucosal lesions. At that, the activities of both isoforms of NO-sythase (inducible and constitutive) decreased, but lipoperoxidation processes remained at the level of stress. The advantage of using H2S-releasing nonsteroidal anti-inflammatory drug ATB-346 is a cytoprotective effect of the latter manifested as a decrease in total area of gastric injury. However, lipoperoxidation processes and NO-syntase activity did not differ substantially from those in the group treated with napoxen, indicating the prevalence of parent molecule (naproxen) in the regulation of NO-system functioning. An administration of a compound 2A5DHT, a dual COX/LOX inhibitor, caused the decrease in gastric injury as compared to naproxen influence. An activity of iNOS remained much higher than under condition of naproxen action.


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