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International Journal of Physiology and Pathophysiology

Erscheint 4 Ausgaben pro Jahr

ISSN Druckformat: 2155-014X

ISSN Online: 2155-0158

SJR: 0.116

The Effect of Ca2+ on the Properties of the Large Conductance Cation Channels of the Nuclear Envelope of the Cerebellar Neurons

Volumen 5, Ausgabe 3, 2014, pp. 193-198
DOI: 10.1615/IntJPhysPathophys.v5.i3.20
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ABSTRAKT

Previously we have found the large conductance cation channels (LCCC) in the nuclear membranes, where numerous inositol-1,4,5-triphosphate receptors (IP3Rs) were also observed. Probably IP3Rs and LCCC are functionally connected: LCCC may provide the counterflow of K,+ which prevents the formation of the negative potential in the lumen of the nuclear envelope, augmenting in such way the Ca2+ release by IP3Rs. LCCC have been poorly studied, and their molecular nature is still unknown. Investigation of the Ca2+ effect on the features of those channels has demonstrated that neither Ca2+-free solution, nor high concentrations of Ca2+ in the nuclear lumen changed significantly the main biophysical features of the LCCC. Thus, the level of Ca2+ repletion of the store does not influence the activity of LCCC.

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