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ISSN Druckformat: 2155-014X
ISSN Online: 2155-0158
The Effect of Ca2+ on the Properties of the Large Conductance Cation Channels of the Nuclear Envelope of the Cerebellar Neurons
ABSTRAKT
Previously we have found the large conductance cation channels (LCCC) in the nuclear membranes, where numerous inositol-1,4,5-triphosphate receptors (IP3Rs) were also observed. Probably IP3Rs and LCCC are functionally connected: LCCC may provide the counterflow of K,+ which prevents the formation of the negative potential in the lumen of the nuclear envelope, augmenting in such way the Ca2+ release by IP3Rs. LCCC have been poorly studied, and their molecular nature is still unknown. Investigation of the Ca2+ effect on the features of those channels has demonstrated that neither Ca2+-free solution, nor high concentrations of Ca2+ in the nuclear lumen changed significantly the main biophysical features of the LCCC. Thus, the level of Ca2+ repletion of the store does not influence the activity of LCCC.