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International Journal of Medicinal Mushrooms
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ISSN Druckformat: 1521-9437
ISSN Online: 1940-4344

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International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.2018025250
pages 1-11

Antiproliferative Activity and Cytotoxicity of Some Medicinal Wood-Destroying Mushrooms from Russia

Alla V. Shnyreva
Department of Mycology and Algology, Faculty of Biology, Moscow Lomonosov State University, Moscow, Russia
Anastasia A. Shnyreva
Department of Mycology and Algology, Faculty of Biology, Moscow Lomonosov State University, Moscow, Russia
Cesar Espinoza
Laboratorio de Alta Tecnologia de Xalapa (LATEX), Universidad Veracruzana. Calle Medicos 5, Unidad del Bosque, 91010, Xalapa, Veracruz, Mexico
José M. Padrón
Instituto Universitario de Bio-Orgánica "Antonio González" (IUBO-AG), Centro de Investigaciones Biomédicas de Canarias (CIBICAN), Universidad de La Laguna, La Laguna, Spain
Ángel Trigos
Universidad Veracruzana

ABSTRAKT

We analyzed the antiproliferative activity of 6 medicinal wood-destroying mushrooms (Fomes fomentarius, Fomitopsis pinicola, Trametes versicolor, Trichaptum biforme, Inonotus obliquus, and Coniophora puteana) that are common in deciduous and mixed coniferous forests in Central Russia. Morphological identification of strains collected from the wild was confirmed based on ribosomal DNA internal transcribed spacer phylogenetic analysis. We observed cytotoxic and cell growth–inhibitory effects of hot water extracts from mycelial biomass of 5 species−T. versicolor, C. puteana, F. fomentarius, F. pinicola, and I. obliquus−on leukemia cell lines (Jukart, K562, and THP-1); the effective extract concentrations were mostly less than 50 μg · mL-1. However, we observed no antiproliferative activity of dry biomass from methanol−chloroform (1:1) extracts of C. puteana and F. fomentarius. A chemosensitivity assay showed that the most effective polypore mushroom extract was the methanol extract of T. versicolor (strain It-1), which inhibited the growth of 6 various solid tumors (A-549 and SWi573 [lung], HBL-100 and T-47D [breast], HeLa [cervix], and WiDr [colon]) at concentrations below 45 μg · mL-1, with a concentration as low as 0.7–3.6 μg · mL-1 causing 50% reduction in the proliferation of cancer cells in lung and cervix tumors. Methanol extracts of F. pinicola and I. obliquus were less effective, with proliferation-inhibiting capacities at concentrations below 70 and 200 μg · mL-1, respectively. Thus, T. versicolor is a prospective candidate in the search for and production of new antiproliferative chemical compounds.


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