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ISSN Druckformat: 1521-9437
ISSN Online: 1940-4344
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p-Terphenyl Compounds Possessing Antioxidative Activity from Japanese Inedible Mushrooms
ABSTRAKT
We are continuing to study biologically active substances from inedible mushrooms. In this paper, we report 36 new p-terphenyl compounds possessing antioxidative activity from fruit bodies of four Japanese inedible fungi named Thelephora aurantiotincta Corner, T. terrestris Ehrn., and Hydnellum caeruleum (Hornem.)P.Karst., belonging to Thelephoraceae; and Paxillus curtisii Berk., belonging to Coniophoraceae. Eight new p-terphenyl compounds, thelephantins A−H (1−8) (Quang et al., 2003a,b) and five known compoundsatro-mentin, 2-O-methylatromentin, gabajunins C and E, and thelephorin Awere isolated from T. aurantiotincta. Eight new p-terphenyl compoundsthelephantins I−P (9−16) (Quang et al., 2004) together with two known compounds, 2-O-methylatromentin and dihydroaurantiacinwere isolated from H. caeruleum, seven new p-terphenyl derivativesterrestrins A−G (17−23) and two new pregnane-type steroids, terrestrones A and B (24, 25) from T. terrestris. In addition, 13 new p-terphenyl derivatives named curtisians E−Q(26−38) (Quang et al., 2003c−e) along with two known compoundscurtisians C and Dwere also obtained from P. curtisii. These absolute structures were determined by 2D NMR, MS, IR, and UV spectra, X-ray crystallographic analysis, and chemical reactions.
Antioxidative activities of these new p-terphenyl compounds were evaluated by diphenyl-p-picryhydrazyl (DPPH) radical scavenging effects. Some new p-terphenyl compounds showed equivalent or strong activities compared with vitamin C, α-tocopherol, and BHA (tert-butylhydroxyanisole).