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International Journal of Medicinal Mushrooms

Erscheint 12 Ausgaben pro Jahr

ISSN Druckformat: 1521-9437

ISSN Online: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

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Protection against X-Ray Irradiation Injury by Chinese Caterpillar Medicinal Mushroom Ophiocordyceps sinensis (Ascomycetes) Polysaccharides in Mice

Volumen 22, Ausgabe 8, 2020, pp. 815-827
DOI: 10.1615/IntJMedMushrooms.2020035696
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ABSTRAKT

Polysaccharides are one of the main active ingredients of Ophiocordyceps sinensis, a traditional Chinese medicinal mushroom. In this study, we investigated the protective effect of O. sinensis polysaccharides (CSPs) against X-ray irradiation in mice. The results indicated that CSPs improved survival rates and times in radiation-injured mice, accelerated the recovery of white blood cells, increased the organ index of thymus and spleen, and increased the DNA content in bone marrow cells. CSPs also increased the activity of superoxide dismutase, decreased the production of malondialdehyde, and reversed the increase in catalase and glutathione peroxidase activity induced by irradiation. Treatment with 100, 200, and 400 mg/kg body weight CSPs caused a significant decrease in the protein and messenger RNA expression of extracellular regulated protein kinase (ERK1), c-Jun N-terminal kinase (JNK1), and p38 mitogen-activated protein kinase (MAPK) after irradiation. Our results demonstrate that CSPs protect mice from injury after exposure to X-ray irradiation, and that this effect may be exerted via the mitogen-activated protein kinase pathway. These findings may provide a basis for the use of CSPs as an effective radioprotector or an alternative strategy in reducing irradiation-induced injury.

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