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International Journal of Medicinal Mushrooms

Erscheint 12 Ausgaben pro Jahr

ISSN Druckformat: 1521-9437

ISSN Online: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

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The Antitumor Activity of Ganoderma lucidum (Curt.:Fr.)P. Karst. (Ling Zhi) (Aphyllophoromycetideae) Polysaccharides Is Related to Tumor Necrosis Factor-α and Interferon-γ

Volumen 1, Ausgabe 3, 1999, pp. 207-215
DOI: 10.1615/IntJMedMushrooms.v1.i3.20
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ABSTRAKT

In the present study, the antitumor activity of GL-B, a polysaccharide isolated from Ganoderma lucidum (Curt:Fr.)P. Karst. and its mechanism were studied in vivo and in vitro. The results were as follows: (1) GL-B 50, 100, 200 μg ml−1 inhibited the growth of implanted Sarcoma 180 in vivo significantly and dose dependently. (2) GL-B directly added to the culture medium neither induced HL-60 apoptosis nor restrained its proliferation in vitro. (3) The macrophage or T lymphocyte culture medium treated with GL-B (GL-B-M-CM or GL-B-T-CM) 50, 100, and 200 μg ml−1 significantly induced HL-60 apoptosis and inhibited its proliferation. GL-B significantly increased tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) release in dose-dependent and time-dependent instances. (4) As untreated macrophages and T lymphocytes produced little or no TNF-α and IFN-γ, and macrophage culture medium with normal saline (N-M-CM) or T lymphocyte culture medium with normal saline (N-T-CM) did not inhibit HL-60 proliferation or induce its apoptosis, it seemed that the antitumor activity of GL-B was related to apoptosis induced by TNF-α-release from macrophages and IFN-γ-release from T lymphocytes.

REFERENZIERT VON
  1. Wang Jianguo, Ma Zhaocheng, Zhang Lina, Fang Yapeng, Jiang Fatang, Phillips Glyn O., Structure and chain conformation of water-soluble heteropolysaccharides from Ganoderma lucidum, Carbohydrate Polymers, 86, 2, 2011. Crossref

  2. Pang X., Chen Z., Gao X., Liu W., Slavin M., Yao W., Yu L.L., Potential of a Novel Polysaccharide Preparation (GLPP) from Anhui-Grown Ganoderma lucidum in Tumor Treatment and Immunostimulation, Journal of Food Science, 72, 6, 2007. Crossref

  3. LIU Gao-Qiang, ZHANG Ke-Chang, Mechanisms of the Anticancer Action of Ganoderma lucidum (Leyss. ex Fr.) Karst.: A New Understanding, Journal of Integrative Plant Biology, 47, 2, 2005. Crossref

  4. ZHU Xiao-ling, LIN Zhi-bin, Effects of Ganoderma lucidum polysaccharides on proliferation and cytotoxicity of cytokine-induced killer cells, Acta Pharmacologica Sinica, 26, 9, 2005. Crossref

  5. LI Wei-dong, ZHANG Bo-di, WEI Ran, LIU Ji-hong, LIN Zhi-bin, Reversal effect of Ganoderma lucidum polysaccharide on multidrug resistance in K562/ADM cell line, Acta Pharmacologica Sinica, 29, 5, 2008. Crossref

  6. Ferreira Isabel C.F.R., Heleno Sandrina A., Reis Filipa S., Stojkovic Dejan, Queiroz Maria João R.P., Vasconcelos M. Helena, Sokovic Marina, Chemical features of Ganoderma polysaccharides with antioxidant, antitumor and antimicrobial activities, Phytochemistry, 114, 2015. Crossref

  7. Du Ming, Zhang Lanwei, Hu Xiaosong, Zhao Guanghua, Characterization and the Immune Regulation Activities in Vitro of Se-GL-P, an Antioxidant Selenium-Containing Protein from Se-Enriched Ganoderma Lucidum Mushroom, 2008 2nd International Conference on Bioinformatics and Biomedical Engineering, 2008. Crossref

  8. Mizerska-Dudka Magdalena, Jaszek Magdalena, Błachowicz Adriana, Rejczak Tomasz Piotr, Matuszewska Anna, Osińska-Jaroszuk Monika, Stefaniuk Dawid, Janusz Grzegorz, Sulej Justyna, Kandefer-Szerszeń Martyna, Fungus Cerrena unicolor as an effective source of new antiviral, immunomodulatory, and anticancer compounds, International Journal of Biological Macromolecules, 79, 2015. Crossref

  9. Cao Li-Zhen, Lin Zhi-Bin, Regulation on maturation and function of dendritic cells by Ganoderma lucidum polysaccharides, Immunology Letters, 83, 3, 2002. Crossref

  10. Zhang Hui-Na, He Jing-Hua, Yuan Lan, Lin Zhi-Bin, In vitro and in vivo protective effect of Ganoderma lucidum polysaccharides on alloxan-induced pancreatic islets damage, Life Sciences, 73, 18, 2003. Crossref

  11. Yuen J.W.M., Gohel M.D.I., Ng C.F., The differential immunological activities of Ganoderma lucidum on human pre-cancerous uroepithelial cells, Journal of Ethnopharmacology, 135, 3, 2011. Crossref

  12. Rashid S., Unyayar A., Mazmanci M.A., McKeown S.R., Banat I.M., Worthington J., A study of anti-cancer effects of Funalia trogii in vitro and in vivo, Food and Chemical Toxicology, 49, 7, 2011. Crossref

  13. Zhongjuan Li, Chaoling Yang, Jinghui Wang, Xin Yu, Hongliang Wang, Zhongliang Zhai, Effect of Artemisia argyi polysaccharide on immunity activity of macrophages and T cells in mouse, 2011 4th International Conference on Biomedical Engineering and Informatics (BMEI), 2011. Crossref

  14. Cao Qi-zhen, Lin Zhi-Bin, Ganoderma lucidum polysaccharides peptide inhibits the growth of vascular endothelial cell and the induction of VEGF in human lung cancer cell, Life Sciences, 78, 13, 2006. Crossref

  15. Boh Bojana, Berovic Marin, Zhang Jingsong, Zhi-Bin Lin, , 13, 2007. Crossref

  16. Nie Shaoping, Zhang Hui, Li Wenjuan, Xie Mingyong, Current development of polysaccharides from Ganoderma: Isolation, structure and bioactivities, Bioactive Carbohydrates and Dietary Fibre, 1, 1, 2013. Crossref

  17. Gill Balraj Singh, Sharma Prateek, Kumar Raj, Kumar Sanjeev, Misconstrued versatility of Ganoderma lucidum: a key player in multi-targeted cellular signaling, Tumor Biology, 37, 3, 2016. Crossref

  18. Gao Yihuai, Gao He, Chan Eli, Tang Wenbo, Xu Anlong, Yang Hongyuan, Huang Min, Lan Jin, Li Xiaotian, Duan Wei, Xu Congjian, Zhou Shufeng, Antitumor Activity and Underlying Mechanisms of Ganopoly, The Refined Polysaccharides Extracted fromGanoderma Lucidum, in Mice, Immunological Investigations, 34, 2, 2005. Crossref

  19. An Na, Wang Dacheng, Zhu Tongfei, Zeng Sheng, Cao Yongguo, Cui Jian, Deng Xuming, Song Yu, Effects of scrocaffeside A fromPicrorhiza Scrophulariifloraon immunocyte function in vitro, Immunopharmacology and Immunotoxicology, 31, 3, 2009. Crossref

  20. Smina T.P., Nitha B., Devasagayam T.P.A, Janardhanan K.K., Ganoderma lucidum total triterpenes induce apoptosis in MCF-7 cells and attenuate DMBA induced mammary and skin carcinomas in experimental animals, Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 813, 2017. Crossref

  21. Zhang Guo-Liang, Hepatoprotective role ofganoderma lucidumpolysaccharide against BCG-induced immune liver injury in mice, World Journal of Gastroenterology, 8, 4, 2002. Crossref

  22. Siow Yaw L, Gong Yuewen, Au-Yeung Kathy K.W, Woo Connie W.H, Choy Patrick C, O Karmin, Emerging issues in traditional Chinese medicine, Canadian Journal of Physiology and Pharmacology, 83, 4, 2005. Crossref

  23. Yuen John, Buswell John, Benzie Iris, Ganoderma lucidum (Lingzhi or Reishi), in Herbal Medicine, 20115386, 2011. Crossref

  24. Xu Jianhua, Li Peng, Researches and Application of Ganoderma Spores Powder, in Ganoderma and Health, 1181, 2019. Crossref

  25. Sun Yu, Sun Lixin, Cellular and Molecular Mechanism of Ganoderma (Lingzhi) Against Tumor, in Ganoderma and Health, 1182, 2019. Crossref

  26. Lin Zhibin, Sun Lixin, Antitumor Effect of Ganoderma (Lingzhi) Mediated by Immunological Mechanism and Its Clinical Application, in Ganoderma and Health, 1182, 2019. Crossref

  27. Kour Harpreet, Kour Satwinder, Sharma Yashpal, Singh Shaveta, Sharma Isha, Kour Divjot, Yadav Ajar Nath, Bioprospecting of Industrially Important Mushrooms, in Industrially Important Fungi for Sustainable Development, 2021. Crossref

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