Abo Bibliothek: Guest
Digitales Portal Digitale Bibliothek eBooks Zeitschriften Referenzen und Berichte Forschungssammlungen
International Journal of Medicinal Mushrooms
Impact-faktor: 1.423 5-jähriger Impact-Faktor: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Druckformat: 1521-9437
ISSN Online: 1940-4344

Volumes:
Volumen 21, 2019 Volumen 20, 2018 Volumen 19, 2017 Volumen 18, 2016 Volumen 17, 2015 Volumen 16, 2014 Volumen 15, 2013 Volumen 14, 2012 Volumen 13, 2011 Volumen 12, 2010 Volumen 11, 2009 Volumen 10, 2008 Volumen 9, 2007 Volumen 8, 2006 Volumen 7, 2005 Volumen 6, 2004 Volumen 5, 2003 Volumen 4, 2002 Volumen 3, 2001 Volumen 2, 2000 Volumen 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v7.i12.130
pages 127-140

The Chemistry, Nutritional Value, Immunopharmacology, and Safety of the Traditional Food of Medicinal Split-Gill Fugus Schizophyllum commune Fr.:Fr. (Schizophyllaceae). A Literature Review

Christopher Hobbs
Institute for Natural Products Research, Davis, CA 95065; and Institute for Natural Products Research, 4731 East Fork Rd., Williams, OR 97544, USA

ABSTRAKT

The cosmopolitan wood-loving mushroom, Schizophyllum commune, is used as a traditional food throughout Southeast Asia and India. Researchers have intensively studied a (13)-β-D-glucan from the mycelium extract, schizophyllan (SPG) since the 1970s, and today it is used as a biological response modifier (BRM) in combination with chemo- and radiation therapy, especially for cervical and gastric cancers. Based on an abundance of preliminary evidence showing binding of its (13)-β-D-glucan to dectin-1 receptors of macrophages and other cells, activation of a T-cell cascade with subsequent increased production of cytokines, such as interleukins and tumor necrosis factor (TNF-α), reduction of tumor size and growth, increased survival of tumor-bearing animals, and a few controlled human trials of varying methodologies and quality, it continues to be used in clinical practice. Larger, well-designed clinical trials are needed to secure its place in modern medical practice in other countries. Fundamental questions such as whether oral application is effective, determination of proper dose, frequency and length of administration, and whether SPG is effective with other types of cancer still need to be answered.


Articles with similar content:

Medicinal Value of Turkey Tail Fungus Trametes versicolor (L.:Fr.) Pilat (Aphyllophoromycetideae)
International Journal of Medicinal Mushrooms, Vol.7, 2005, issue 3
Christopher Hobbs
Treating Colorectal Cancer with Western and Chinese Medicine
Forum on Immunopathological Diseases and Therapeutics, Vol.2, 2011, issue 4
C. Junghanss, M. Leithauser, Hans Lampe, M. Freund
Medicinal Value of Turkey Tail Fungus Trametes versicolor (L.:Fr.) Pilát (Aphyllophoromycetideae). A Literature Review
International Journal of Medicinal Mushrooms, Vol.6, 2004, issue 3
Christopher Hobbs
Effect of Immunomodulating and Antiviral Agent of Medicinal Mushrooms (Immune Assist 24/7TM) on CD4+ T-Lymphocyte Counts of HIV-Infected Patients
International Journal of Medicinal Mushrooms, Vol.13, 2011, issue 2
Braimah Saaka, Abraham Quarcoo, Gideon Adotey, John Holliday, Solomon Fofie
Immunotherapy for EBV-Associated Nasopharyngeal Carcinoma
Critical Reviews™ in Oncogenesis, Vol.23, 2018, issue 3-4
Mengying Hong, Ren Sun, Jing Qian, Hongyu Deng, Shu Zheng, Kejun Tang, Yushen Du, Kefeng Ding, Musheng Zeng