Erscheint 12 Ausgaben pro Jahr
ISSN Druckformat: 1521-9437
ISSN Online: 1940-4344
Indexed in
Analysis of Antibacterial Activity and Bioactive Compounds of the Giant Mushroom, Macrocybe gigantea (Agaricomycetes), from India
ABSTRAKT
The antibacterial activity, phenolic profile, and bioactive compounds of fruiting bodies from 2 strains (MA1 and MA2) of the giant mushroom Macrocybe gigantea were evaluated to access their nutraceutical efficacy. The antibacterial activity was higher in MA2 against all selected pathogenic bacteria. Selected phenolics were analyzed by high-performance liquid chromatography coupled with ultraviolet-visible detection. Gallic acid, ferulic acid, quercetin, p-hydroxy benzoic acid, cinnamic acid, and rutin contents (micrograms per gram dry weight) were quantified. Quercetin and rutin were absent in both strains of M. gigantea. M. gigantea MA2 showed relatively higher phenolic content (915.8 μg/g dry weight) than M. gigantea MA1 (854.4 μg/g dry weight). Among the phenolics, gallic acid is found in the largest amount; in M. gigantea MA2, it was 847.9 ± 2.67 μg/g dry weight. Gas chromatography–mass spectrometry analysis showed the presence of bioactive compounds in both strains; most compounds were antibacterial. Thus, the selected strains of M. gigantea can combat oxidative damage and can be used in foods, pharmaceuticals, and cosmetics because of their antioxidant potential.
-
Vilariño Marcos, García-Sanmartín Josune, Ochoa-Callejero Laura, López-Rodríguez Alberto, Blanco-Urgoiti Jaime, Martínez Alfredo, Macrocybin, a Natural Mushroom Triglyceride, Reduces Tumor Growth In Vitro and In Vivo through Caveolin-Mediated Interference with the Actin Cytoskeleton, Molecules, 25, 24, 2020. Crossref
-
Kui Ling, Zhang Zhe, Wang Yangzi, Zhang Yesheng, Li Shiming, Dong Xiao, Xia Qiuju, Sheng Jun, Wang Jian, Dong Yang, Xu Yuzhen, Genome Assembly and Analyses of the Macrofungus Macrocybe gigantea, BioMed Research International, 2021, 2021. Crossref
-
Rangsinth Panthakarn, Sillapachaiyaporn Chanin, Nilkhet Sunita, Tencomnao Tewin, Ung Alison T., Chuchawankul Siriporn, Mushroom-derived bioactive compounds potentially serve as the inhibitors of SARS-CoV-2 main protease: An in silico approach, Journal of Traditional and Complementary Medicine, 11, 2, 2021. Crossref
-
Hasan Mahamudul, Mia Md Mukthar, Islam Md Mazharul, Hasan Saraf Md Sawkat, Islam Md Shariful, A computerized pharmaceutical repurposing approach reveals Semicochliodinol B synthesized from Chrysosporium merdarium as a viable therapeutic contender for Marburg virus's VP35 and VP40 proteins, Informatics in Medicine Unlocked, 28, 2022. Crossref
-
Mia Md. Mukthar, Hasan Mahamudul, Hasan Md. Abir, Shahid Hossain Mohammad Abdus, Islam Md. Mazharul, Hasan Saraf Md. Sawkat, Discovery of mushroom-derived bioactive compound's draggability against nsP3 macro domain, nsP2 protease and envelope glycoprotein of Chikungunya virus: An in silico approach, Informatics in Medicine Unlocked, 26, 2021. Crossref