Erscheint 12 Ausgaben pro Jahr
ISSN Druckformat: 1521-9437
ISSN Online: 1940-4344
Indexed in
Hepatoprotective Effects and Mechanisms of Action of Triterpenoids from Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Agaricomycetes) on α-Amanitin-Induced Liver Injury in Mice
ABSTRAKT
Most fatal mushroom poisonings are caused by species of the genus Amanita; the amatoxins are responsible for acute liver failure and death in humans. Ganoderma lucidum is a well-known traditional medicinal mushroom that has been shown to have obvious hepatoprotective effects. This study evaluated the hepatoprotective effects of triterpenoids from G. lucidum on liver injury induced by a-amanitin (α-AMA) in mice and the mechanisms of action of these triterpenoids, including radical scavenging and antiapoptosis activities. Mice were treated with α-AMA, followed by G. lucidum total triterpenoids or individual triterpenoids, and their hepatoprotective effects were compared with those of the reference drug silibinin (SIL). Treatment with SIL, G. lucidum total triterpenoids, and each of the 5 individual triterpenoids significantly reduced serum alanine aminotransaminase and aspartate ami- notransaminase concentrations and reduced mortality rates 20-40%. Moreover, triterpenoids and SIL significantly enhanced superoxide dismutase and catalase activity and reduced malondialdehyde content in livers. Treatment with ganoderic acid C2 significantly inhibited DNA fragmentation and decreased caspase-3, -8, and -9 activities. The results demonstrated that triterpenoids have hepatoprotective effects on α-AMA-induced liver injury and that their hepatoprotective mechanisms may be the result of their antioxidative and radical scavenging activities and their inhibition of apoptosis.
-
Zhao Ruo-lin, He Yu-min, Network pharmacology analysis of the anti-cancer pharmacological mechanisms of Ganoderma lucidum extract with experimental support using Hepa1-6-bearing C57 BL/6 mice, Journal of Ethnopharmacology, 210, 2018. Crossref
-
Jayachandran Muthukumaran, Xiao Jianbo, Xu Baojun, A Critical Review on Health Promoting Benefits of Edible Mushrooms through Gut Microbiota, International Journal of Molecular Sciences, 18, 9, 2017. Crossref
-
Ye Yongzhuang, Liu Zhenning, Management of Amanita phalloides poisoning: A literature review and update, Journal of Critical Care, 46, 2018. Crossref
-
Zhao Chao, Fan Jinlin, Liu Yuanyuan, Guo Weiling, Cao Hui, Xiao Jianbo, Wang Ying, Liu Bin, Hepatoprotective activity of Ganoderma lucidum triterpenoids in alcohol-induced liver injury in mice, an iTRAQ-based proteomic analysis, Food Chemistry, 271, 2019. Crossref
-
Jatsa Hermine Boukeng, Feussom Nestor Gipwe, Femoe Ulrich Membe, Kenfack Mérimé Christian, Nkondo Emilienne Tienga, Kadji Fassi Joseph Bertin, Simo Nadège Distele, Moaboulou Cyriaque, Dongmo Calvine Noumedem, Tsague Christelle Dongmo, Dongo Etienne, Kamtchouing Pierre, Tchuem Tchuente Louis-Albert, Evaluation of the schistosomicidal, antioxidant and anti-inflammatory activities of the ethyl acetate fraction from Ozoroa pulcherrima Schweinf. Roots on Schistosoma mansoni-induced liver pathology in mice and its phytochemical characterization, Journal of Ethnopharmacology, 238, 2019. Crossref
-
Govorushko Sergey, Rezaee Ramin, Dumanov Josef, Tsatsakis Aristidis, Poisoning associated with the use of mushrooms: A review of the global pattern and main characteristics, Food and Chemical Toxicology, 128, 2019. Crossref
-
Geng Xiaoqiang, Zhong Dandan, Su Limin, Yang Baoxue, Preventive and Therapeutic Effect of Ganoderma (Lingzhi) on Renal Diseases and Clinical Applications, in Ganoderma and Health, 1182, 2019. Crossref
-
Arici M. Aylin, Tuncok Yesim, Mushroom-related toxins, alpha amanitin, and usage of antioxidants: Directions toward antioxidant capacity, in Toxicology, 2021. Crossref
-
Adotey Gideon, Alolga Raphael N., Quarcoo Abraham, Gedel Mohammed Ahmed, Anang Abraham K., Holliday John C., Ultra Performance Liquid Chromatography-Quadrupole Time-of-Flight Mass Spectrometry (UPLC-Q-TOF-MS)-based metabolomic analysis of mycelial biomass of three Ganoderma isolates from the Lower Volta River Basin of Ghana, Journal of Pharmaceutical and Biomedical Analysis, 205, 2021. Crossref
-
Chen Ruirong, Ping Zhaohua, Chen Junjia, Liang Lei, Lu Chuanli, Mycelia Extract from Spent Ganoderma Lucidum Bagasse Substrate Ameliorates Carbon Tetrachloride-Induced Acute Liver Injury in Mice Through Inhibiting Oxidative Stress, Waste and Biomass Valorization, 12, 6, 2021. Crossref
-
Gryzenhout Marieka, Ghosh Soumya, Tchotet Tchoumi James Michel, Vermeulen Marcele, Kinge Tonjock Rosemary, Ganoderma: Diversity, Ecological Significances, and Potential Applications in Industry and Allied Sectors, in Industrially Important Fungi for Sustainable Development, 2021. Crossref
-
Zhou Shuai, Zhang Xiaoyu, Ma Fuying, Xie Shangxian, Tang Chuanhong, Tang Qingjiu, Zhang Jingsong, Cann Isaac, Integrative Analysis of Selected Metabolites and the Fungal Transcriptome during the Developmental Cycle of Ganoderma lucidum Strain G0119 Correlates Lignocellulose Degradation with Carbohydrate and Triterpenoid Metabolism, Applied and Environmental Microbiology, 87, 13, 2021. Crossref
-
Ahmad Rizwan, Riaz Muhammad, Khan Aslam, Aljamea Ahmed, Algheryafi Mohammad, Sewaket Deya, Alqathama Aljawharah, Ganoderma lucidum (Reishi) an edible mushroom; a comprehensive and critical review of its nutritional, cosmeceutical, mycochemical, pharmacological, clinical, and toxicological properties , Phytotherapy Research, 35, 11, 2021. Crossref
-
Liu Jiaxin, Wang Yuxin, Wu Jianzhong, Georgiev Milen I., Xu Baojun, Wong Ka-Hing, Bai Weibin, Tian Lingmin, Isolation, Structural Properties, and Bioactivities of Polysaccharides from Mushrooms Termitomyces: A Review, Journal of Agricultural and Food Chemistry, 70, 1, 2022. Crossref
-
Lin Simei, Meng Jia, Li Fei, Yu Huifan, Lin Dongmei, Lin Shuqian, Li Min, Zhou Hong, Yang Baoxue, Ganoderma lucidumpolysaccharide peptide alleviates hyperuricemia by regulating adenosine deaminase and urate transporters, Food & Function, 13, 24, 2022. Crossref