Abo Bibliothek: Guest
International Journal of Medicinal Mushrooms

Erscheint 12 Ausgaben pro Jahr

ISSN Druckformat: 1521-9437

ISSN Online: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

Indexed in

Hepatoprotective Effects and Mechanisms of Action of Triterpenoids from Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Agaricomycetes) on α-Amanitin-Induced Liver Injury in Mice

Volumen 18, Ausgabe 9, 2016, pp. 841-850
DOI: 10.1615/IntJMedMushrooms.v18.i9.80
Get accessGet access

ABSTRAKT

Most fatal mushroom poisonings are caused by species of the genus Amanita; the amatoxins are responsible for acute liver failure and death in humans. Ganoderma lucidum is a well-known traditional medicinal mushroom that has been shown to have obvious hepatoprotective effects. This study evaluated the hepatoprotective effects of triterpenoids from G. lucidum on liver injury induced by a-amanitin (α-AMA) in mice and the mechanisms of action of these triterpenoids, including radical scavenging and antiapoptosis activities. Mice were treated with α-AMA, followed by G. lucidum total triterpenoids or individual triterpenoids, and their hepatoprotective effects were compared with those of the reference drug silibinin (SIL). Treatment with SIL, G. lucidum total triterpenoids, and each of the 5 individual triterpenoids significantly reduced serum alanine aminotransaminase and aspartate ami- notransaminase concentrations and reduced mortality rates 20-40%. Moreover, triterpenoids and SIL significantly enhanced superoxide dismutase and catalase activity and reduced malondialdehyde content in livers. Treatment with ganoderic acid C2 significantly inhibited DNA fragmentation and decreased caspase-3, -8, and -9 activities. The results demonstrated that triterpenoids have hepatoprotective effects on α-AMA-induced liver injury and that their hepatoprotective mechanisms may be the result of their antioxidative and radical scavenging activities and their inhibition of apoptosis.

REFERENZIERT VON
  1. Zhao Ruo-lin, He Yu-min, Network pharmacology analysis of the anti-cancer pharmacological mechanisms of Ganoderma lucidum extract with experimental support using Hepa1-6-bearing C57 BL/6 mice, Journal of Ethnopharmacology, 210, 2018. Crossref

  2. Jayachandran Muthukumaran, Xiao Jianbo, Xu Baojun, A Critical Review on Health Promoting Benefits of Edible Mushrooms through Gut Microbiota, International Journal of Molecular Sciences, 18, 9, 2017. Crossref

  3. Ye Yongzhuang, Liu Zhenning, Management of Amanita phalloides poisoning: A literature review and update, Journal of Critical Care, 46, 2018. Crossref

  4. Zhao Chao, Fan Jinlin, Liu Yuanyuan, Guo Weiling, Cao Hui, Xiao Jianbo, Wang Ying, Liu Bin, Hepatoprotective activity of Ganoderma lucidum triterpenoids in alcohol-induced liver injury in mice, an iTRAQ-based proteomic analysis, Food Chemistry, 271, 2019. Crossref

  5. Jatsa Hermine Boukeng, Feussom Nestor Gipwe, Femoe Ulrich Membe, Kenfack Mérimé Christian, Nkondo Emilienne Tienga, Kadji Fassi Joseph Bertin, Simo Nadège Distele, Moaboulou Cyriaque, Dongmo Calvine Noumedem, Tsague Christelle Dongmo, Dongo Etienne, Kamtchouing Pierre, Tchuem Tchuente Louis-Albert, Evaluation of the schistosomicidal, antioxidant and anti-inflammatory activities of the ethyl acetate fraction from Ozoroa pulcherrima Schweinf. Roots on Schistosoma mansoni-induced liver pathology in mice and its phytochemical characterization, Journal of Ethnopharmacology, 238, 2019. Crossref

  6. Govorushko Sergey, Rezaee Ramin, Dumanov Josef, Tsatsakis Aristidis, Poisoning associated with the use of mushrooms: A review of the global pattern and main characteristics, Food and Chemical Toxicology, 128, 2019. Crossref

  7. Geng Xiaoqiang, Zhong Dandan, Su Limin, Yang Baoxue, Preventive and Therapeutic Effect of Ganoderma (Lingzhi) on Renal Diseases and Clinical Applications, in Ganoderma and Health, 1182, 2019. Crossref

  8. Arici M. Aylin, Tuncok Yesim, Mushroom-related toxins, alpha amanitin, and usage of antioxidants: Directions toward antioxidant capacity, in Toxicology, 2021. Crossref

  9. Adotey Gideon, Alolga Raphael N., Quarcoo Abraham, Gedel Mohammed Ahmed, Anang Abraham K., Holliday John C., Ultra Performance Liquid Chromatography-Quadrupole Time-of-Flight Mass Spectrometry (UPLC-Q-TOF-MS)-based metabolomic analysis of mycelial biomass of three Ganoderma isolates from the Lower Volta River Basin of Ghana, Journal of Pharmaceutical and Biomedical Analysis, 205, 2021. Crossref

  10. Chen Ruirong, Ping Zhaohua, Chen Junjia, Liang Lei, Lu Chuanli, Mycelia Extract from Spent Ganoderma Lucidum Bagasse Substrate Ameliorates Carbon Tetrachloride-Induced Acute Liver Injury in Mice Through Inhibiting Oxidative Stress, Waste and Biomass Valorization, 12, 6, 2021. Crossref

  11. Gryzenhout Marieka, Ghosh Soumya, Tchotet Tchoumi James Michel, Vermeulen Marcele, Kinge Tonjock Rosemary, Ganoderma: Diversity, Ecological Significances, and Potential Applications in Industry and Allied Sectors, in Industrially Important Fungi for Sustainable Development, 2021. Crossref

  12. Zhou Shuai, Zhang Xiaoyu, Ma Fuying, Xie Shangxian, Tang Chuanhong, Tang Qingjiu, Zhang Jingsong, Cann Isaac, Integrative Analysis of Selected Metabolites and the Fungal Transcriptome during the Developmental Cycle of Ganoderma lucidum Strain G0119 Correlates Lignocellulose Degradation with Carbohydrate and Triterpenoid Metabolism, Applied and Environmental Microbiology, 87, 13, 2021. Crossref

  13. Ahmad Rizwan, Riaz Muhammad, Khan Aslam, Aljamea Ahmed, Algheryafi Mohammad, Sewaket Deya, Alqathama Aljawharah, Ganoderma lucidum (Reishi) an edible mushroom; a comprehensive and critical review of its nutritional, cosmeceutical, mycochemical, pharmacological, clinical, and toxicological properties , Phytotherapy Research, 35, 11, 2021. Crossref

  14. Liu Jiaxin, Wang Yuxin, Wu Jianzhong, Georgiev Milen I., Xu Baojun, Wong Ka-Hing, Bai Weibin, Tian Lingmin, Isolation, Structural Properties, and Bioactivities of Polysaccharides from Mushrooms Termitomyces: A Review, Journal of Agricultural and Food Chemistry, 70, 1, 2022. Crossref

  15. Lin Simei, Meng Jia, Li Fei, Yu Huifan, Lin Dongmei, Lin Shuqian, Li Min, Zhou Hong, Yang Baoxue, Ganoderma lucidumpolysaccharide peptide alleviates hyperuricemia by regulating adenosine deaminase and urate transporters, Food & Function, 13, 24, 2022. Crossref

2597 Artikelansichten 39 Artikel-Downloads Metriken
2597 ANSICHTEN 39 HERUNTERLADEN 15 Crossref ZITATE Google
Scholar
ZITATE

Artikel mit ähnlichem Inhalt:

Hepatoprotective Effects of Aqueous Extract from Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Higher Basidiomycetes) on α-Amanitin−Induced Liver Injury in Mice International Journal of Medicinal Mushrooms, Vol.15, 2013, issue 4
Jinsong Hu, Xin Wu, Jun Zeng, Qiong Liao, Zuohong Chen, Rong Zhou, Ping Zhang
Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), as a Cardioprotectant in an Oxygen-Deficient Environment International Journal of Medicinal Mushrooms, Vol.19, 2017, issue 11
Kshipra Misra, Sarita Nehra, Jigni Mishra, Vandana Kirar, Rakhee, Deepika Saraswat
Antioxidant Potential of Black Tea Against 7,12-Dimethylbenz(a)anthracene- Induced Oxidative Stress in Swiss Albino Mice Journal of Environmental Pathology, Toxicology and Oncology, Vol.24, 2005, issue 2
Sahdeo Prasad, Neetu Kalra, Yogeshwer Shukla
Hepatoprotection of Gentiana scabra Extract and Polyphenols in Liver of Carbon Tetrachloride-Intoxicated Mice Journal of Environmental Pathology, Toxicology and Oncology, Vol.30, 2011, issue 3
Jyun-Han Chen, Lean-Teik Ng, Huey-Jiun Ko
Gracilaria bursa-pastoris (Gmelin) Silva Extract Attenuates Ultraviolet B Radiation−Induced Oxidative Stress in Human Keratinocytes Journal of Environmental Pathology, Toxicology and Oncology, Vol.33, 2014, issue 1
C.W. Yao, N.H. Lee, K.C. Kim, H.K. Kang, Mi Hee Ko, E.S. Yoo, J. Zheng, J.W. Cha, Jin Won Hyuna, Mei Jing Piao, Y.S. Koh
Digitales Portal Digitale Bibliothek eBooks Zeitschriften Referenzen und Berichte Forschungssammlungen Preise und Aborichtlinien Begell House Kontakt Language English 中文 Русский Português German French Spain