Abo Bibliothek: Guest
Digitales Portal Digitale Bibliothek eBooks Zeitschriften Referenzen und Berichte Forschungssammlungen
International Journal of Medicinal Mushrooms
Impact-faktor: 1.423 5-jähriger Impact-Faktor: 1.525 SJR: 0.431 SNIP: 0.716 CiteScore™: 2.6

ISSN Druckformat: 1521-9437
ISSN Online: 1940-4344

Volumen 22, 2020 Volumen 21, 2019 Volumen 20, 2018 Volumen 19, 2017 Volumen 18, 2016 Volumen 17, 2015 Volumen 16, 2014 Volumen 15, 2013 Volumen 14, 2012 Volumen 13, 2011 Volumen 12, 2010 Volumen 11, 2009 Volumen 10, 2008 Volumen 9, 2007 Volumen 8, 2006 Volumen 7, 2005 Volumen 6, 2004 Volumen 5, 2003 Volumen 4, 2002 Volumen 3, 2001 Volumen 2, 2000 Volumen 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/InterJMedicMush.v5.i4.40
14 pages

A Randomized, Placebo-Controlled, Multicenter Study of Ganoderma lucidum (W.Curt.:Fr.) Lloyd (Aphyllophoromycetideae) Polysaccharides (Ganopoly®) in Patients with Advanced Lung Cancer

Yihuai Gao
Institute of Food, Nutrition and Human Health, Massey University; Landcare Research, Private Bag 92170, Auckland, New Zealand
Xihu Dai
Department of Internal Medicine, Fuzhou General Hospital of Nanjing Military Region of the Peoples' Liberation Army, Fuzhou, R.P. China
Guoliang Chen
Division of Traditional Chinese Medicine, New Zealand Institute of Natural Medicines, Auckland, New Zealand
Jingxian Ye
Department of Integrated Medicine. Hospital of Fujian University of Traditional Chinese Medicine, Fuzhou, R.P. China
Shufeng Zhou
Division of Pharmacy, School of Life Sciences, Faculty of Science, Queensland University of Technology, Australia; Department of Pharmacy, Faculty of Science, National University of Singapore; University of South Florida FL 33612, USA


Preclinical studies have established that the polysaccharide fractions of Ganoderma lucidum (Ling Zhi, reishi mashroom) have potential antitumor activity. Recent clinical studies have demonstrated that G. lucidum polysaccharides enhanced host immune functions (e.g., enhanced natural killer cell activity) in patients with advanced solid tumor, although objective response was not observed. A randomized double-blind, placebo-controlled, multicenter clinical trial was conducted to evaluate the efficacy and safety of the G. lucidum polysaccharides, Ganopoly®, in patients with advanced lung cancer. Sixty-eight patients with histologically confirmed advanced lung cancer were enrolled. Eligibility criteria included con. rmation of diagnosis, objective measurable disease, a Karnofsky performance score і60, life expectancy of 12 weeks or greater, no recent or concomitant anticancer therapy, and informed consent. Patients were evaluated with respect to their extent of disease and quality of life (Karnofsky score), and hematologic and selected immunological and biochemical studies at baseline and after 12 weeks of treatment with oral Ganopoly or placebo at 600 mg three times daily. Patients in both groups were similar with respect to age, sex, treatment history, and lung tumor histology. Treatment with Ganopoly gave stable disease (SD) in 13 (13/37, 35.1%) lung cancer patients at the 12-week evaluation point, which was significantly greater than that of control group (7/31, 22.6%). In 32 assessable cancer patient, treatment of Ganopoly resulted in a significant increase (>10 scores) in the KPS scores in 16 patients (50.0%); 4 patients (14.3%) obtained significant increase in the KPS scores in the control group with 29 assessable patients (p < 0.05); and 9 (28.1%) and 7 (21.9%) patients receiving Ganopoly had unchanged and reduced KPS scores, respectively. Values were 13 (46.4%) and 11 (39.3%) in the control group. Palliative effects on cancer-related symptoms such as fever, cough, weakness, sweating and insomnia have been observed in of cancer patients receiving Ganopoly, but only a small percentage ( of cancer patients receiving placebo demonstrated improved cancer-related symptoms. Administration of Ganopoly for 12 weeks resulted in a significant (p < 0.05) increase in lymphocyte mitogenic reactivity to concanavalin A, CD3 percentage, and natural killer cell activity; a marginal increase in the CD4 percentage and CD4/CD8 ratio; but a marginal reduction of CD8. However, all these immune parameters remained unchanged or decreased in the control group. Three episodes of mild toxicity (nausea: 2; insomnia: 1) were recorded in patients receiving Ganopoly, and one episode of toxicity (vomiting) was recorded in the control group. The results indicate that Ganopoly may have an adjunct role in the treatment of patients with advanced lung cancer. Further studies are needed to explore the optimum dosing, efficacy, and safety of Ganopoly when used alone or in combination with chemotherapy/radiotherapy.

Articles with similar content:

A Phase I/II Study of a Ganoderma lucidum (Curt.: Fr.) P. Karst. Extract (Ganopofy) in Patients with Advanced Cancer
International Journal of Medicinal Mushrooms, Vol.4, 2002, issue 3
Guoliang Chen, Jingxian Ye, Yihuai Gao, Shufeng Zhou, Xihu Dai
Immune Responses to Water-Soluble Ling Zhi Mushroom Ganoderma lucidum (W.Curt.:Fr.) P. Karst. Polysaccharides in Patients with Advanced Colorectal Cancer
International Journal of Medicinal Mushrooms, Vol.7, 2005, issue 4
Guoliang Chen, He Gao, Jingxian Ye, Yihuai Gao, Min Huang, Eli Chan, Wenbo Tang, Shufeng Zhou, Xihu Dai
Randomized Clinical Trial for the Evaluation of Immune Modulation by Yogurt Enriched with β-Glucans from Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), in Children from Medellin, Colombia
International Journal of Medicinal Mushrooms, Vol.20, 2018, issue 8
Edwin A. Higuita, Andrea M. Cano, Sandra Lorena Duque Henao, Sergio A. Urrego
Clinical Trials for Medicinal Mushrooms: Experience with Ganoderma lucidum (W.Curt.:Fr.) Lloyd (Lingzhi Mushroom)
International Journal of Medicinal Mushrooms, Vol.7, 2005, issue 1&2
Yihuai Gao, Eli Chan, Shufeng Zhou
A Phase I/II Study of Ling Zhi Mushroom Ganoderma lucidum (W.Curt.:Fr.) Lloyd (Aphyllophoromycetideae) Extract in Patients with Coronary Heart Disease
International Journal of Medicinal Mushrooms, Vol.6, 2004, issue 4
Guoliang Chen, Jingxian Ye, Yihuai Gao, Shufeng Zhou, Xihu Dai