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International Journal of Medicinal Mushrooms
Impact-faktor: 1.423 5-jähriger Impact-Faktor: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Druckformat: 1521-9437
ISSN Online: 1940-4344

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International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v13.i3.20
pages 227-236

28-Day Oral Safety Evaluation of Extracellular Polysaccharopeptides Produced in Submerged Culture from the Turkey Tail Medicinal Mushroom Trametes versicolor (L.:Fr.) Pilát LH-1 in Mice

Chun-Hong Lai
Department of Nutritional Science, Fu Jen Catholic University, 510 Jhongjheng Road, Sinjhuang City, Taipei County 24205, Taiwan
Ju-Fang Teng
Department of Nutritional Science, Fu Jen Catholic University, 510 Jhongjheng Road, Sinjhuang City, Taipei County 24205, Taiwan
Tai-Hao Hsu
Department of Medicinal Botanicals and Health Applications, Da-Yeh University, Datsuen, Changhua, 51591, Taiwan (R. O. C.); Department of Bioindustry Technology, Da-Yeh University, Datsuen, Changhua, 51591, Taiwan (R. O. C.)
Fang-Yi Lin
Department of Bioindustry Technology, Da-Yeh University, Datsuen, Changhua, 51591, Taiwan
Po-Wen Yang
Department of Bioindustry Technology, Da-Yeh University, Datsuen, Changhua, 51591, Taiwan
Hui-Chen Lo
Department of Natural Sciences, Fu Jen Catholic University, #510, JhongZheng Rd., Xinzhuang District, New Taipei City, 24205, Taiwan, ROC

ABSTRAKT

Turkey tail medicinal mushroom, Trametes versicolor (TV), is a species with a variety of pharmacological activities. Its intracellular polysaccharopeptides are widely commercialized. Recently, we found a novel TV strain LH-1 in Taiwan and demonstrated that the extracellular polysaccharopeptide (ePSP) of LH-1 obtained from submerged culture exhibits significant immunomodulatory activity. In this in vivo study, we further evaluated the safety of orally administered LH-1 ePSP using both male and female ICR mice. The LH-1 ePSP was orally administered to mice at levels of 0 (water), 100 (low dose), 500 (medium dose), or 1000 mg/kg/day (high dose) for 28 days. Clinical observations, growth, food consumption, histopathological examination, and clinical biochemical analyses revealed no adverse effects of LH-1 ePSP in mice. There were no significant differences in the results of target organ weights, hematological analyses, and urinalysis examination among groups. However, male mice that ingested high doses of LH-1 ePSP tended to have decreased lung weights and platelet numbers. In conclusion, the results of the present study suggested that oral administration of LH-1 ePSP for 28 days is accompanied by no obvious signs of toxicity. The lack of toxicity supports the potential use of LH-1 ePSP as a food or dietary supplement.