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ISSN Druckformat: 1521-9437
ISSN Online: 1940-4344
Indexed in
Studies on the Triterpenoid Constituents of the Spores of Ganoderma lucidum (Curt.: Fr.) P. Karst. (Aphyllophoromycetideae)
ABSTRAKT
Five compounds were isolated from the ether-soluble fraction of the spores of Ganoderma lucidum (Curt.: Fr.) P. Karst. On the basis of their chemical properties and spectral data (MS, UV, IR, 1H, and 13C-NMR), they were identified as 3,7,11,12,15,23-hexaoxo-5α-lanosta-8-en-26-oic acid (I); ganoderic acids B (II), C (III), and E (IV); and ganodermanontriol (V). Compound I is a new natural product named ganosporeric acid A. Compounds II, III, IV, and V are known compounds and were obtained for the first time from the spores of G. lucidum. Pharmacological experiments showed that ganosporeric acid A has GPT-lowering activity in mice with liver injury caused by CCI4 and GaNI and exhibits hepaoprotective effects.
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Paterson R. Russell M., Ganoderma – A therapeutic fungal biofactory, Phytochemistry, 67, 18, 2006. Crossref
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Müller Claudia I., Kumagai Takashi, O’Kelly James, Seeram Navindra P., Heber David, Koeffler H. Phillip, Ganoderma lucidum causes apoptosis in leukemia, lymphoma and multiple myeloma cells, Leukemia Research, 30, 7, 2006. Crossref
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Zhang Hui, Li Wen-Juan, Nie Shao-Ping, Chen Yi, Wang Yuan-Xing, Xie Ming-Yong, Structural characterisation of a novel bioactive polysaccharide from Ganoderma atrum, Carbohydrate Polymers, 88, 3, 2012. Crossref
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Alambin F., Motamed Fath P., Ebrahimi Hosseinzadeh B., Hatamian Zarmi A., Sahraeian R., Yazdian F., Leukemia stem cells, direct targeting of CD123 based on the nano-smart polymer PMBN, RSC Advances, 6, 98, 2016. Crossref