Abo Bibliothek: Guest
Digitales Portal Digitale Bibliothek eBooks Zeitschriften Referenzen und Berichte Forschungssammlungen
International Journal of Medicinal Mushrooms
Impact-faktor: 1.423 5-jähriger Impact-Faktor: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Druckformat: 1521-9437
ISSN Online: 1940-4344

Volumes:
Volumen 21, 2019 Volumen 20, 2018 Volumen 19, 2017 Volumen 18, 2016 Volumen 17, 2015 Volumen 16, 2014 Volumen 15, 2013 Volumen 14, 2012 Volumen 13, 2011 Volumen 12, 2010 Volumen 11, 2009 Volumen 10, 2008 Volumen 9, 2007 Volumen 8, 2006 Volumen 7, 2005 Volumen 6, 2004 Volumen 5, 2003 Volumen 4, 2002 Volumen 3, 2001 Volumen 2, 2000 Volumen 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.v17.i8.40
pages 735-747

Chemical Composition and Medicinal Value of the New Ganoderma tsugae var. jannieae CBS-120304 Medicinal Higher Basidiomycete Mushroom

Jannie Siew Lee Chan
Phyto Pharma Ltd., Singapore
Mikheil D. Asatiani
Animal Husbandry and Feed Production Institute Agricultural University of Georgia, 240 David Agmashenebeli Alley, 0159 Tbilisi, Georgia
Lital E. Sharvit
Department of Evolutionary and Environmental Biology and Institute of Evolution, Faculty of Natural Sciences, University of Haifa, Mount Carmel, Haifa 31905, Israel
Beny Trabelcy
Department of Evolutionary and Environmental Biology and Department of Human Biology, Faculty of Natural Sciences, University of Haifa, Mt. Carmel, Haifa, Israel
Gayane S. Barseghyan
Institute of Evolution and Department of Evolutionary & Environmental Biology, Faculty of Natural Sciences, University of Haifa, Mt. Carmel, Haifa 31905, Israel; 433, rue de la Noue, Verdun (Montreal), QC, H3E 1R9, Canada
Solomon P. Wasser
N.G. Kholodny Institute of Botany, NAS of Ukraine, 2 Tereshchenkovskaya Str., Kiev 01004, Ukraine; International Center for Cryptogamic Plants and Fungi, Institute of Evolution, University of Haifa, Mount Carmel, Haifa, Israel

ABSTRAKT

In this research, the chemical composition and anticancer and antioxidant activity of the new medicinal mushroom Ganoderma tsugae var. jannieae CBS-120304 were evaluated. The chemical composition assay includes amounts of total carbohydrates and proteins, amino acids, fatty acids, micro- and macroelements, and vitamins. The investigated medicinal mushroom seemed to be a rich source of nutritional components. Mycelium accumulated more than 2-fold more total protein compared with the fruiting body and reached 37% and 16% of dry weight, respectively. Carbohydrate content in the fruiting body seemed to be conspicuously higher than in the mycelium (50% of dry weight) and reached 80% of dry weight. Quantification of the identified fatty acids indicated that, in general, palmitic acid, oleic acid, and linoleic acid were the major fatty acids. Toxic elements, such as silver, arsenic, cadmium, and mercury, were found only in trace amounts in mycelium and were not detected in the fruiting body. Furthermore, the 1,1-diphenyl-2-picrylhydrazyl free radical scavenging assay was used to evaluate antioxidant activity. The highest radical scavenging activity was 9.0 mg/mL (65.9%) by ethanol extract. In addition, mycelial extracts were tested to inhibit MCF7 breast cancer cells. Ganoderma tsugae var. jannieae ethyl acetate extract (GTEAE) extract showed high potential by inhibiting reporter activity by more than 70%. Results demonstrated that GTEAE had a strong effect on inhibitory protein κΒα level in the higher concentration used (200 gg/mL), which could be compared with the effect of parthenolide. Furthermore, GTEAE demonstrated strong inhibition of IκΒα phosphorylation.


Articles with similar content:

Antioxidant, Anti-Inflammatory, and Antitumor Activities of Cultured Mycelia and Fruiting Bodies of the Elm Oyster Mushroom, Hypsizygus ulmarius (Agaricomycetes)
International Journal of Medicinal Mushrooms, Vol.18, 2016, issue 3
Kainoor K. Janardhanan, Korattuvalappil S. Ravikumar, Karattuthodi Fathimathu Zuhara, Panavalappil Greeshma, Mangalathmelathil N. Neethu, Meera Pandey
Complex Enzyme-Assisted Extraction, Purification, and Antioxidant Activity of Polysaccharides from the Button Mushroom, Agaricus bisporus (Higher Basidiomycetes)
International Journal of Medicinal Mushrooms, Vol.17, 2015, issue 10
Xiulian Yin, Qinghong You, Xinghai Zhou
Investigations on Antioxidative Potential of Poroid Medicinal Mushroom Porodaedalea pini (Agaricomycetes)
International Journal of Medicinal Mushrooms, Vol.21, 2019, issue 6
Minni Singh, Niharika Kaushal, Navpreet Kaur, Gurpaul Singh Dhingra, Avneet Pal Singh
Antioxidant Activity of Submerged Cultured Mycelium Extracts of Higher Basidiomycetes Mushrooms
International Journal of Medicinal Mushrooms, Vol.9, 2007, issue 2
Abraham Reznick, Mikheil D. Asatiani, Vladimir I. Elisashvili, Eviatar D. Nevo
Comparison of the Chemical Composition and Bioactive Components of Fruiting Bodies and Submerged Cultured Mycelia of the Willow Bracket Medicinal Mushroom, Phellinus igniarius (Agaricomycetes)
International Journal of Medicinal Mushrooms, Vol.18, 2016, issue 9
Huawei Zeng, Menghua Ma, Mei Ying-jie, Jianfan Sund, Wenfeng Wang, Guohua Xu