Abo Bibliothek: Guest
Digitales Portal Digitale Bibliothek eBooks Zeitschriften Referenzen und Berichte Forschungssammlungen
International Journal of Medicinal Mushrooms
Impact-faktor: 1.423 5-jähriger Impact-Faktor: 1.525 SJR: 0.431 SNIP: 0.716 CiteScore™: 2.6

ISSN Druckformat: 1521-9437
ISSN Online: 1940-4344

Volumes:
Volumen 22, 2020 Volumen 21, 2019 Volumen 20, 2018 Volumen 19, 2017 Volumen 18, 2016 Volumen 17, 2015 Volumen 16, 2014 Volumen 15, 2013 Volumen 14, 2012 Volumen 13, 2011 Volumen 12, 2010 Volumen 11, 2009 Volumen 10, 2008 Volumen 9, 2007 Volumen 8, 2006 Volumen 7, 2005 Volumen 6, 2004 Volumen 5, 2003 Volumen 4, 2002 Volumen 3, 2001 Volumen 2, 2000 Volumen 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v4.i4.20
7 pages

Antidiabetic Effect of an Acidic Polysaccharide (TAP) from Tremella aurantia Schw.: Fr. (Heterobasidiomycetes) in Genetically Diabetic КК-Аy Mice

Tadashi Kiho
Laboratory of Medical Regulations, Gifu Pharmaceutical University, Japan
Mari Kochi
Gifu Pharmaceutical University, 5-6-1 Mitahora-higashi, Gifu 502-8585, Japan
Shigeyuki Usui
Laboratory of Pharmaceutics, Gifu Pharmaceutical University, Gifu 502-8585, Japan
Kazuyuki Hirano
Laboratory of Pharmaceutics, Gifu Pharmaceutical University, Gifu 502-8585, Japan
Koichi Aizawa
Research Institute, Kagome Co., Ltd., 17 Nishitomiyama, Nishinasuno-machi, Nasu-gun, Tochigi 329-2762, Japan
Takahiro Inakuma
Research Institute, Kagome Co., Ltd., 17 Nishitomiyama, Nishinasuno-machi, Nasu-gun, Tochigi 329-2762, Japan

ABSTRAKT

Antidiabetic effect of an acidic polysaccharide obtained from the fruiting bodies of Tremella aurantia was studied. Continuous oral administration of а T. aurantia acidic polysaccharide (TAP) solution (0.5 g/L) instead of water to genetically non-insulin-dependent diabetic model (KK-Ay) mice, being already in diabetic condition, were found to depress plasma glucose increases. TAP significantly lowered levels of total-cholesterol, free cholesterol, free fatty acid, and triglyceride in the blood of the mice, and significantly increased high-density lipoprotein (HDL) cholesterol ratio. TAP also significantly lowered the level of free fatty acid in epididymal adipose tissue, while triglyceride content in the tissue was slightly increased. On the other hand, TAP significantly increased glycogen content in hindlimb muscle tissue. The study shows that TAP has an antidiabetic effect, even if the diabetic mice were already at a high plasma glucose level.


Articles with similar content:

Antihyperglycemic and Antilipidperoxidative Effects of Polysaccharides Extracted from Medicinal Mushroom Chaga, Inonotus obliquus (Pers.: Fr.) Pilát (Aphyllophoromycetideae) on Alloxan-Diabetes Mice
International Journal of Medicinal Mushrooms, Vol.12, 2010, issue 3
Yitong Zheng, Hong-Yu Xu, Xin Xu, Zhenming Lu, Chengjian Yang, Zheng-Hong Xu, Chong Pang
Effect of Probiotic Therapy on the Experimental Obesity Development in Rats Caused by Monosodium Glutamate
International Journal of Physiology and Pathophysiology, Vol.6, 2015, issue 2
O. V. Virchenko, Tetyana V. Beregova, L. P. Babenko, Tetyana M. Falalyeyeva, O.A. Savchenyuk, Mykola Ya. Spivak, L. M. Lazarenko
Effects of Yellow Brain Culinary-Medicinal Mushroom, Tremella mesenterica Ritz.:Fr. (Higher Basidiomycetes), on Immune Function in Normal and Type 1 Diabetic Rats
International Journal of Medicinal Mushrooms, Vol.14, 2012, issue 5
Solomon P. Wasser, Fang-Yi Lin, Chien-Hsing Lee, Yu-Hsin Chen, Tai-Hao Hsu, Hui-Chen Lo
Immunomodulatory Effect of Polysaccharides Extracted from the Medicinal Mushroom Antrodia camphorata (Higher Basidiomycetes) in Specific Pathogen-Free Chickens
International Journal of Medicinal Mushrooms, Vol.16, 2014, issue 1
Ai-Rong Song, Chen Zhao, Song Yang, Fang Huang, Chao Kong, Xiao-Le Sun, Dan Qin
Submerged-Culture Mycelia and Broth of the Maitake Medicinal Mushroom Grifola frondosa (Higher Basidiomycetes) Alleviate Type 2 Diabetes-Induced Alterations in Immunocytic Function
International Journal of Medicinal Mushrooms, Vol.17, 2015, issue 6
Ya-Hui Chen, Chien-Hsing Lee, Tai-Hao Hsu, Hui-Chen Lo