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ISSN Druckformat: 0892-0915
ISSN Online: 2375-0014
Schizophrenia and Glutamatergic Transmission
ABSTRAKT
Schizophrenia is a human brain disease with well-defined symptoms and a lifelong disease course, but without a current biological explanation. Several observations implicate brain glutamatergic abnormalities in the pathophysiology of this illness. This evidence includes both human neurochemical and clinical pharmacologic data. Furthermore the psychotomimetic action of phencyclidine, the noncompetitive NMDA-sensitive glutamate receptor antagonist, suggests the association between human psychosis and NMDA receptor blockade. This paper reviews basic aspects of glutamatergic transmission in animal and human brain with particular attention to its putative role in schizophrenia. Consideration is given to other glutamate-related human brain diseases and their purported mechanisms. Evidence of glutamatergic abnormalities in schizophrenia is critically reviewed, including data using postmortem neurochemistry, in vivo human brain imaging, clinical pharmacology, and animal models. The current theoretical formulations based on these studies are articulated. We propose a "working" glutamate hypothesis of schizophrenia which postulates a diminished glutamatergic transmission in the hippocampal glutamate-mediated efferent pathways and cerebral dysfunction in the hippocampus and its target areas, especially the anterior cingulate cortex. Considerable work remains to be done in this area to formulate and test a comprehensive hypothesis.
-
Doi Nagafumi, Hoshi Yoko, Itokawa Masanari, Yoshikawa Takeo, Ichikawa Tomoe, Arai Makoto, Usui Chie, Tachikawa Hirokazu, Paradox of schizophrenia genetics: is a paradigm shift occurring?, Behavioral and Brain Functions, 8, 1, 2012. Crossref
-
Dwyer Donard S, Lu Xiao-Hong, III Arthur M Freeman, Neuronal glucose metabolism and schizophrenia: therapeutic prospects?, Expert Review of Neurotherapeutics, 3, 1, 2003. Crossref
-
Koga Eiko, Momiyama Toshihiko, Presynaptic dopamine D 2 ‐like receptors inhibit excitatory transmission onto rat ventral tegmental dopaminergic neurones , The Journal of Physiology, 523, 1, 2000. Crossref
-
Schaus John M., Bymaster Frank P., , 33, 1998. Crossref
-
Hockberger Robert S., Richards John R., Thought Disorders, in Rosen's Emergency Medicine – Concepts and Clinical Practice, 2010. Crossref
-
Traverso Luis M., Ruiz Gabriel, De la Casa Luis G., Effect of the NMDA antagonist MK-801 on latent inhibition of fear conditioning, Pharmacology Biochemistry and Behavior, 102, 4, 2012. Crossref
-
Holcomb Henry H, Lahti Adrienne C, Medoff Deborah R, Cullen Tom, Tamminga Carol A, Effects of Noncompetitive NMDA Receptor Blockade on Anterior Cingulate Cerebral Blood Flow in Volunteers with Schizophrenia, Neuropsychopharmacology, 30, 12, 2005. Crossref
-
Fowler Jill H., Whalley Katherine, Murray Tracey, O'Neill Michael J., McCulloch James, The AMPA Receptor Potentiator LY404187 Increases Cerebral Glucose Utilization and c-fos Expression in the Rat, Journal of Cerebral Blood Flow & Metabolism, 24, 10, 2004. Crossref
-
Singh B., Recognition and optimal management of schizophrenia and related psychoses, Internal Medicine Journal, 35, 7, 2005. Crossref
-
Bagorda F., Teuchert-Noodt G., Lehmann K., Isolation rearing or methamphetamine traumatisation induce a “dysconnection” of prefrontal efferents in gerbils: implications for schizophrenia, Journal of Neural Transmission, 113, 3, 2006. Crossref
-
Lees Gordon J., Pharmacology of AMPA/Kainate Receptor Ligands and Their Therapeutic Potential in Neurological and Psychiatric Disorders, Drugs, 59, 1, 2000. Crossref
-
Tamminga C. A., Southcott S., Sacco C., Wagner A. D., Ghose S., Glutamate Dysfunction in Hippocampus: Relevance of Dentate Gyrus and CA3 Signaling, Schizophrenia Bulletin, 38, 5, 2012. Crossref
-
Schwarz Emanuel, Bahn Sabine, Cerebrospinal fluid: identification of diagnostic markers for schizophrenia, Expert Review of Molecular Diagnostics, 8, 2, 2008. Crossref
-
Stone Trevor W., Stoy Nicholas, Darlington L. Gail, An expanding range of targets for kynurenine metabolites of tryptophan, Trends in Pharmacological Sciences, 34, 2, 2013. Crossref
-
Tarazi Frank I, Neill Jo C, The preclinical profile of asenapine: clinical relevance for the treatment of schizophrenia and bipolar mania, Expert Opinion on Drug Discovery, 8, 1, 2013. Crossref
-
Paus Sebastian, Rietschel Marcella, Schulze Thomas G., Ohlraun Stephanie, Diaconu Carmen C., Den Bogaert Ann Van, Maier Wolfgang, Propping Peter, Cichon Sven, N??then Markus M., Systematic screening for mutations in the human N-methyl-D-aspartate receptor 1 gene in schizophrenic patients from the German population, Psychiatric Genetics, 14, 4, 2004. Crossref
-
Martres Marie-Pascale, Les systèmes de neurotransmission centraux et leur implication dans les psychoses, Therapies, 63, 3, 2008. Crossref
-
Ceresoli-Borroni G., Rassoulpour A., Wu H.-Q., Guidetti P., Schwarcz R., Chronic neuroleptic treatment reduces endogenous kynurenic acid levels in rat brain, Journal of Neural Transmission, 113, 10, 2006. Crossref
-
Ishiguro Hiroki, Saito Toshikazu, Shibuya Haruo, Toru Michio, Arinami Tadao, Mutation and association analysis of the Fyn kinase gene with alcoholism and schizophrenia, American Journal of Medical Genetics, 96, 6, 2000. Crossref
-
Gao Xue-Min, Hashimoto Takeshi, Tamminga Carol A., Phencyclidine (PCP) and dizocilpine (MK801) exert time-dependent effects on the expression of immediate early genes in rat brain, Synapse, 29, 1, 1998. Crossref
-
Vinogradova O.S., Hippocampus as comparator: Role of the two input and two output systems of the hippocampus in selection and registration of information, Hippocampus, 11, 5, 2001. Crossref
-
MIYAMOTO Yoshiaki, NABESHIMA Toshitaka, Analysis of neuronal functions in mice lacking the NMDA receptor .EPSILON.1 subunit., Folia Pharmacologica Japonica, 119, 6, 2002. Crossref
-
Zhang Lin, Shirayama Yukihiko, Iyo Masaomi, Hashimoto Kenji, Minocycline Attenuates Hyperlocomotion and Prepulse Inhibition Deficits in Mice after Administration of the NMDA Receptor Antagonist Dizocilpine, Neuropsychopharmacology, 32, 9, 2007. Crossref
-
Barros Virginia G., Berger María A., Martijena Irene D., Sarchi María I., Pérez Adriana A., Molina Victor A., Tarazi Frank I., Antonelli Marta C., Early adoption modifies the effects of prenatal stress on dopamine and glutamate receptors in adult rat brain, Journal of Neuroscience Research, 76, 4, 2004. Crossref
-
Hikichi Hirohiko, Kaku Ayaka, Karasawa Jun-ichi, Chaki Shigeyuki, Stimulation of Metabotropic Glutamate (mGlu) 2 Receptor and Blockade of mGlu1 Receptor Improve Social Memory Impairment Elicited by MK-801 in Rats, Journal of Pharmacological Sciences, 122, 1, 2013. Crossref
-
Hickey Andrea J., Reynolds James N., Beninger Richard J., Post-weaning social isolation and subchronic NMDA glutamate receptor blockade: Effects on locomotor activity and GABA signaling in the rat suggest independent mechanisms, Pharmacology Biochemistry and Behavior, 101, 2, 2012. Crossref
-
Benes Francine M., Neural Circuitry Models of Schizophrenia: Is it Dopamine, GABA, Glutamate, or Something Else?, Biological Psychiatry, 65, 12, 2009. Crossref
-
Henson Maile A., Roberts Adam C., Salimi Kayvon, Vadlamudi Swarooparani, Hamer Robert M., Gilmore John H., Jarskog L. Fredrik, Philpot Benjamin D., Developmental Regulation of the NMDA Receptor Subunits, NR3A and NR1, in Human Prefrontal Cortex, Cerebral Cortex, 18, 11, 2008. Crossref
-
Berretta Sabina, Lange Nicholas, Bhattacharyya Sujoy, Sebro Ronnie, Garces Jessica, Benes Francine M., Long-term effects of amygdala GABA receptor blockade on specific subpopulations of hippocampal interneurons, Hippocampus, 14, 7, 2004. Crossref
-
Basta-Kaim A., Fijał K., Budziszewska B., Regulska M., Leśkiewicz M., Kubera M., Gołembiowska K., Lasoń W., Wędzony K., Prenatal lipopolysaccharide treatment enhances MK-801-induced psychotomimetic effects in rats, Pharmacology Biochemistry and Behavior, 98, 2, 2011. Crossref
-
Esiri Margaret, Crow Tim, Psychiatric diseases, in Greenfield's Neuropathology Eighth Edition. 2 Volume Set and DVD, 2008. Crossref
-
Moy Sheryl S., Perez Antonio, Koller Beverly H., Duncan Gary E., Amphetamine-induced disruption of prepulse inhibition in mice with reduced NMDA receptor function, Brain Research, 1089, 1, 2006. Crossref
-
Papp Andras, Juranyi Zsolt, Nagymajtenyi Laszlo, Matyus Peter, Harsing Laszlo G., The synaptic and nonsynaptic glycine transporter type-1 inhibitors Org-24461 and NFPS alter single neuron firing rate in the rat dorsal raphe nucleus, Neurochemistry International, 52, 1-2, 2008. Crossref
-
Rezvani Amir, Involvement of the NMDA System in Learning and Memory, in Animal Models of Cognitive Impairment, 20064835, 2006. Crossref
-
Lin Chi-Ying, Sawa Akira, Jaaro-Peled Hanna, Better understanding of mechanisms of schizophrenia and bipolar disorder: From human gene expression profiles to mouse models, Neurobiology of Disease, 45, 1, 2012. Crossref
-
Fukumoto Makoto, Iwata Masaaki, Shinbori Chiko, Hazama Gen-i, Shirayama Yukihiko, Kawahara Ryuzou, Effects of acute administration of methamphetamine on Narp mRNA in rat brain, Addiction Biology, 10, 3, 2005. Crossref
-
Yanagi Masaya, Southcott Sarah, Lister Jacob, Tamminga Carol A., Animal Models of Schizophrenia, in Animal Models of Molecular Pathology, 105, 2012. Crossref
-
Pantazopoulos Harry, Stone David, Walsh John, Benes Francine M., Differences in the cellular distribution of D1 receptor mRNA in the hippocampus of bipolars and schizophrenics, Synapse, 54, 3, 2004. Crossref
-
Gallinat Jürgen, Götz Thomas, Kalus Peter, Bajbouj Malek, Sander Thomas, Winterer Georg, Genetic Variations of the NR3A Subunit of the NMDA Receptor Modulate Prefrontal Cerebral Activity in Humans, Journal of Cognitive Neuroscience, 19, 1, 2007. Crossref
-
Cohen Martin, Solowij Nadia, Carr Vaughan, Cannabis, Cannabinoids and Schizophrenia: Integration of the Evidence, Australian & New Zealand Journal of Psychiatry, 42, 5, 2008. Crossref
-
Wu H.-Q., Okuyama M., Kajii Y., Pocivavsek A., Bruno J. P., Schwarcz R., Targeting Kynurenine Aminotransferase II in Psychiatric Diseases: Promising Effects of an Orally Active Enzyme Inhibitor, Schizophrenia Bulletin, 40, Suppl 2, 2014. Crossref
-
Gray Laura, van den Buuse Maarten, Scarr Elizabeth, Dean Brian, Hannan Anthony J., Clozapine reverses schizophrenia-related behaviours in the metabotropic glutamate receptor 5 knockout mouse: association with N-methyl-d-aspartic acid receptor up-regulation, The International Journal of Neuropsychopharmacology, 12, 01, 2009. Crossref
-
Flores Cecilia, Wen Xianglan, Labelle-Dumais Cassandre, Kolb Bryan, Chronic phencyclidine treatment increases dendritic spine density in prefrontal cortex and nucleus accumbens neurons, Synapse, 61, 12, 2007. Crossref
-
Gaisler-Salomon I., Diamant L., Rubin C., Weiner I., Abnormally persistent latent inhibition induced by MK801 is reversed by risperidone and by positive modulators of NMDA receptor function: differential efficacy depending on the stage of the task at which they are administered, Psychopharmacology, 196, 2, 2008. Crossref
-
Stone Trevor W, Kynurenic acid antagonists and kynurenine pathway inhibitors, Expert Opinion on Investigational Drugs, 10, 4, 2001. Crossref
-
Amitai Nurith, Kuczenski Ronald, Behrens M. Margarita, Markou Athina, Repeated phencyclidine administration alters glutamate release and decreases GABA markers in the prefrontal cortex of rats, Neuropharmacology, 62, 3, 2012. Crossref
-
Tamminga C, The limbic cortex in schizophrenia: focus on the anterior cingulate, Brain Research Reviews, 31, 2-3, 2000. Crossref
-
Lazarewicz Maciej T., Ehrlichman Richard S., Maxwell Christina R., Gandal Michael J., Finkel Leif H., Siegel Steven J., Ketamine Modulates Theta and Gamma Oscillations, Journal of Cognitive Neuroscience, 22, 7, 2010. Crossref
-
Camara Marie lou, Corrigan Frances, Jaehne Emily J, Jawahar Magdalene C, Anscomb Helen, Baune Bernhard T, Effects of Centrally Administered Etanercept on Behavior, Microglia, and Astrocytes in Mice Following a Peripheral Immune Challenge, Neuropsychopharmacology, 40, 2, 2015. Crossref
-
Choi Changho, Dimitrov Ivan, Douglas Deborah, Zhao Chenguang, Hawesa Halima, Ghose Subroto, Tamminga Carol A., In vivo detection of serine in the human brain by proton magnetic resonance spectroscopy (1 H-MRS) at 7 Tesla, Magnetic Resonance in Medicine, 62, 4, 2009. Crossref
-
O'Neill Michael J., Murray Tracey K., Clay Michael P., Lindstrom Terry, Yang Charles R., Nisenbaum Eric S., LY503430: Pharmacology, Pharmacokinetics, and Effects in Rodent Models of Parkinson's Disease, CNS Drug Reviews, 11, 1, 2006. Crossref
-
Schizophrenia, in Wiley Handbook of Current and Emerging Drug Therapies, 2007. Crossref
-
Moghaddam Bita, Homayoun Houman, Dopamine and Glutamate Hypotheses of Schizophrenia, in Handbook of Contemporary Neuropharmacology, 2007. Crossref
-
Lovelace Jonathan W, Vieira Philip A, Corches Alex, Mackie Ken, Korzus Edward, Impaired Fear Memory Specificity Associated with Deficient Endocannabinoid-Dependent Long-Term Plasticity, Neuropsychopharmacology, 39, 7, 2014. Crossref
-
Tomitaka Shinichiro, Tomitaka Midori, Tolliver Bryan K., Sharp Frank R., Bilateral blockade of NMDA receptors in anterior thalamus by dizocilpine (MK-801) injures pyramidal neurons in rat retrosplenial cortex, European Journal of Neuroscience, 12, 4, 2000. Crossref
-
Gray Laura, McOmish Caitlin E., Scarr Elizabeth, Dean Brian, Hannan Anthony J., Sensitivity to MK-801 in phospholipase C-β1 knockout mice reveals a specific NMDA receptor deficit, The International Journal of Neuropsychopharmacology, 12, 07, 2009. Crossref
-
Hackler E.A., Byun N.E., Jones C.K., Williams J.M., Baheza R., Sengupta S., Grier M.D., Avison M., Conn P.J., Gore J.C., Selective potentiation of the metabotropic glutamate receptor subtype 2 blocks phencyclidine-induced hyperlocomotion and brain activation, Neuroscience, 168, 1, 2010. Crossref
-
Quirk Jennifer C., Nisenbaum Eric S., LY404187: A Novel Positive Allosteric Modulator of AMPA Receptors, CNS Drug Reviews, 8, 3, 2006. Crossref
-
Tarazi Frank I., Baldessarini Ross J., Regional localization of dopamine and ionotropic glutamate receptor subtypes in striatolimbic brain regions, Journal of Neuroscience Research, 55, 4, 1999. Crossref
-
Leewanich Pathama, Tohda Michihisa, Takayama Hiromitsu, Sophasan Samaisukh, Watanabe Hiroshi, Matsumoto Kinzo, Corymine Potentiates NMDA-Induced Currents in Xenopus Oocytes Expressing NR1a/NR2B Glutamate Receptors, Journal of Pharmacological Sciences, 98, 1, 2005. Crossref
-
Hinterhoelzl Josef K., Salimi Kayvon, Humpel Christian, Singewald Nicolas, Adlassnig Christine, Fischer-Colbrie Reiner, Fleischhacker Wolfgang W., Marksteiner Josef, Differential effects of phencyclidine application on secretogranin II expression in organotypic slices of rat prefrontal cortex, Journal of Neurochemistry, 87, 1, 2003. Crossref
-
Talpos John C., Aerts Nancy, Fellini Laetitia, Steckler Thomas, A touch-screen based paired-associates learning (PAL) task for the rat may provide a translatable pharmacological model of human cognitive impairment, Pharmacology Biochemistry and Behavior, 122, 2014. Crossref
-
Pickering Chris, Ericson Mia, Söderpalm Bo, Chronic Phencyclidine Increases Synapsin-1 and Synaptic Adaptation Proteins in the Medial Prefrontal Cortex, ISRN Psychiatry, 2013, 2013. Crossref
-
Vogels Tim P, Abbott L F, Gating multiple signals through detailed balance of excitation and inhibition in spiking networks, Nature Neuroscience, 12, 4, 2009. Crossref
-
Nakazawa Kazu, Zsiros Veronika, Jiang Zhihong, Nakao Kazuhito, Kolata Stefan, Zhang Shuqin, Belforte Juan E., GABAergic interneuron origin of schizophrenia pathophysiology, Neuropharmacology, 62, 3, 2012. Crossref
-
Bujas-Bobanovic M, Bird D C, Robertson H A, Dursun S M, Blockade of phencyclidine-induced effects by a nitric oxide donor, British Journal of Pharmacology, 130, 5, 2000. Crossref
-
Cyr , Ghribi , Di Paolo , Regional and Selective Effects of Oestradiol and Progesterone on NMDA and AMPA Receptors in the Rat Brain, Journal of Neuroendocrinology, 12, 5, 2001. Crossref
-
WEST ANTHONY R., FLORESCO STAN B., CHARARA ALI, ROSENKRANZ J. AMIEL, GRACE ANTHONY A., Electrophysiological Interactions between Striatal Glutamatergic and Dopaminergic Systems, Annals of the New York Academy of Sciences, 1003, 1, 2003. Crossref
-
Nakazato Atsuro, Okuyama Shigeru, Recent advances in novel atypical antipsychotic agents: potential therapeutic agents for the treatment of schizophrenia, Expert Opinion on Therapeutic Patents, 10, 1, 2000. Crossref
-
HARRISON PAUL J., LAW AMANDA J., EASTWOOD SHARON L., Glutamate Receptors and Transporters in the Hippocampus in Schizophrenia, Annals of the New York Academy of Sciences, 1003, 1, 2003. Crossref
-
STEFANI MARK R., MOGHADDAM BITA, Distinct Contributions of Glutamate Receptor Subtypes to Cognitive Set-Shifting Abilities in the Rat, Annals of the New York Academy of Sciences, 1003, 1, 2003. Crossref
-
López-Gil Xavier, Babot Zoila, Amargós-Bosch Mercè, Suñol Cristina, Artigas Francesc, Adell Albert, Clozapine and Haloperidol Differently Suppress the MK-801-Increased Glutamatergic and Serotonergic Transmission in the Medial Prefrontal Cortex of the Rat, Neuropsychopharmacology, 32, 10, 2007. Crossref
-
Nagy Katalin, Marko Bernadett, Zsilla Gabriella, Matyus Peter, Pallagi Katalin, Szabo Geza, Juranyi Zsolt, Barkoczy Jozsef, Levay Gyorgy, Harsing Laszlo G., Alterations in Brain Extracellular Dopamine and Glycine Levels Following Combined Administration of the Glycine Transporter Type-1 Inhibitor Org-24461 and Risperidone, Neurochemical Research, 35, 12, 2010. Crossref
-
Locklear M.N., Bhamidipaty S., Kritzer M.F., Local N-methyl-d-aspartate receptor antagonism in the prefrontal cortex attenuates spatial cognitive deficits induced by gonadectomy in adult male rats, Neuroscience, 288, 2015. Crossref
-
McCormick Laurie M., Boles Ponto Laura L., Pierson Ron K., Johnson Hans J., Magnotta Vincent, Brumm Michael C., Metabolic Correlates of Antidepressant and Antipsychotic Response in Patients With Psychotic Depression Undergoing Electroconvulsive Therapy, The Journal of ECT, 23, 4, 2007. Crossref
-
TAMMINGA CAROL A., LAHTI ADRIENNE C., MEDOFF DEBORAH R., GAO XUE-MIN, HOLCOMB HENRY H., Evaluating Glutamatergic Transmission in Schizophrenia, Annals of the New York Academy of Sciences, 1003, 1, 2003. Crossref
-
Arad Michal, Weiner Ina, Sex-Dependent Antipsychotic Capacity of 17β-Estradiol in the Latent Inhibition Model: A Typical Antipsychotic Drug in Both Sexes, Atypical Antipsychotic Drug in Males, Neuropsychopharmacology, 35, 11, 2010. Crossref
-
MOGHADDAM BITA, JACKSON MARK E., Glutamatergic Animal Models of Schizophrenia, Annals of the New York Academy of Sciences, 1003, 1, 2003. Crossref
-
Citri Ami, Malenka Robert C, Synaptic Plasticity: Multiple Forms, Functions, and Mechanisms, Neuropsychopharmacology, 33, 1, 2008. Crossref
-
Gasbarri Antonella, Pompili Assunta, Involvement of Glutamate in Learning and Memory, in Identification of Neural Markers Accompanying Memory, 2014. Crossref
-
Schuitz Susan K, Andreasen Nancy C, Schizophrenia, The Lancet, 353, 9162, 1999. Crossref
-
Deutsch Stephen I, Rosse Richard B, Billingslea Eddie N, Bellack Alan S, Mastropaolo John, Modulation of MK-801-elicited mouse popping behavior by galantamine is complex and dose-dependent, Life Sciences, 73, 18, 2003. Crossref
-
Tsou Jonathan Y., Intervention, causal reasoning, and the neurobiology of mental disorders: Pharmacological drugs as experimental instruments, Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences, 43, 2, 2012. Crossref
-
Wong Albert Hung Choy, Van Tol Hubert H.M., Schizophrenia: from phenomenology to neurobiology, Neuroscience & Biobehavioral Reviews, 27, 3, 2003. Crossref
-
Elsworth J. D., Groman S. M., Jentsch J. D., Leranth C., Redmond D. E., Kim J. D., Diano S., Roth R. H., Primate Phencyclidine Model of Schizophrenia: Sex-Specific Effects on Cognition, Brain Derived Neurotrophic Factor, Spine Synapses, and Dopamine Turnover in Prefrontal Cortex, International Journal of Neuropsychopharmacology, 18, 6, 2015. Crossref
-
Ingason A, Giegling I, Hartmann A M, Genius J, Konte B, Friedl M, Ripke S, Sullivan P F, St. Clair D, Collier D A, O'Donovan M C, Mirnics K, Rujescu D, Expression analysis in a rat psychosis model identifies novel candidate genes validated in a large case–control sample of schizophrenia, Translational Psychiatry, 5, 10, 2015. Crossref
-
Koenig James I., Schizophrenia: A unique translational opportunity in behavioral neuroendocrinology, Hormones and Behavior, 50, 4, 2006. Crossref
-
Stefani Mark Renato, Moghaddam Bita, Transient N-methyl-D-aspartate receptor blockade in early development causes lasting cognitive deficits relevant to schizophrenia, Biological Psychiatry, 57, 4, 2005. Crossref
-
Boyer Patrice, Phillips Jennifer L., Rousseau François L., Ilivitsky Susan, Hippocampal abnormalities and memory deficits: New evidence of a strong pathophysiological link in schizophrenia, Brain Research Reviews, 54, 1, 2007. Crossref
-
Hajszan Tibor, Leranth Csaba, Roth Robert H., Subchronic Phencyclidine Treatment Decreases the Number of Dendritic Spine Synapses in the Rat Prefrontal Cortex, Biological Psychiatry, 60, 6, 2006. Crossref
-
Zhang Boyu, Yuan Yanbo, Jia Yanbin, Yu Xin, Xu Qi, Shen Yucun, Shen Yan, An association study between polymorphisms in five genes in glutamate and GABA pathway and paranoid schizophrenia, European Psychiatry, 20, 1, 2005. Crossref
-
Benes Francine M, Vincent Stephen L, Todtenkopf Mark, The density of pyramidal and nonpyramidal neurons in anterior cingulate cortex of schizophrenic and bipolar subjects, Biological Psychiatry, 50, 6, 2001. Crossref
-
Talpos John, Aerts Nancy, Waddell Jason, Steckler Thomas, MK-801 and amphetamine result in dissociable profiles of cognitive impairment in a rodent paired associates learning task with relevance for schizophrenia, Psychopharmacology, 232, 21-22, 2015. Crossref
-
Swayze Richard D., Lisé Marie-France, Levinson Joshua N., Phillips Anthony, El-Husseini Alaa, Modulation of dopamine mediated phosphorylation of AMPA receptors by PSD-95 and AKAP79/150, Neuropharmacology, 47, 5, 2004. Crossref
-
Phillips Dean, Sonnenberg Jennifer, Arai Amy C, Vaswani Rishi, Krutzik Peter O, Kleisli Thomas, Kessler Markus, Granger Richard, Lynch Gary, Richard Chamberlin A, 5′-Alkyl-benzothiadiazides: A New Subgroup of AMPA Receptor Modulators with Improved Affinity, Bioorganic & Medicinal Chemistry, 10, 5, 2002. Crossref
-
Goudie Andrew J, Smith Judith A, Discriminative Stimulus Properties of Antipsychotics, Pharmacology Biochemistry and Behavior, 64, 2, 1999. Crossref
-
Castner Stacy A., Williams Graham V., Tuning the engine of cognition: A focus on NMDA/D1 receptor interactions in prefrontal cortex, Brain and Cognition, 63, 2, 2007. Crossref
-
Wang Xun, Gu Zhenglin, Zhong Ping, Chen Guojun, Feng Jian, Yan Zhen, Aberrant regulation of NMDA receptors by dopamine D4 signaling in rats after phencyclidine exposure, Molecular and Cellular Neuroscience, 31, 1, 2006. Crossref
-
Koch Michael, Schmiedt-Fehr Christina, Mathes Birgit, Neuropharmacology of altered brain oscillations in schizophrenia, International Journal of Psychophysiology, 103, 2016. Crossref
-
Hashimoto Kenji, Fujimura Masatake, Yamagami Keiji, Dizocilpine-induced neuropathological changes in rat retrosplenial cortex are reversed by subsequent clozapine treatment, Life Sciences, 66, 12, 2000. Crossref
-
Jadi Monika P., Behrens M. Margarita, Sejnowski Terrence J., Abnormal Gamma Oscillations in N-Methyl-D-Aspartate Receptor Hypofunction Models of Schizophrenia, Biological Psychiatry, 79, 9, 2016. Crossref
-
Heresco-Levy Uriel, Ermilov Marina, Lichtenberg Pesah, Bar Gali, Javitt Daniel C, High-dose glycine added to olanzapine and risperidone for the treatment of schizophrenia, Biological Psychiatry, 55, 2, 2004. Crossref
-
Deutsch Stephen I, Rosse Richard B, Billingslea Eddie N, Bellack Alan S, Mastropaolo John, Topiramate antagonizes MK-801 in an animal model of schizophrenia, European Journal of Pharmacology, 449, 1-2, 2002. Crossref
-
Danbolt Niels C, Glutamate uptake, Progress in Neurobiology, 65, 1, 2001. Crossref
-
Magri Chiara, Gardella Rita, Valsecchi Paolo, Barlati Stefano Davide, Guizzetti Luca, Imperadori Laura, Bonvicini Cristian, Tura Gian Battista, Gennarelli Massimo, Sacchetti Emilio, Barlati Sergio, Study on GRIA2, GRIA3 and GRIA4 genes highlights a positive association between schizophrenia and GRIA3 in female patients, American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 147B, 6, 2008. Crossref
-
Álvarez Edgardo O, Ruarte Marcela B, Glutamic acid and histamine-sensitive neurons in the ventral hippocampus and the basolateral amygdala of the rat: functional interaction on memory and learning processes, Behavioural Brain Research, 152, 2, 2004. Crossref
-
Corti Corrado, Crepaldi Luca, Mion Silvia, Roth Adelheid L., Xuereb John H., Ferraguti Francesco, Altered Dimerization of Metabotropic Glutamate Receptor 3 in Schizophrenia, Biological Psychiatry, 62, 7, 2007. Crossref
-
Okamura Naoe, Hashimoto Kenji, Shimizu Eiji, Koike Kaori, Ohgake Shintaro, Koizumi Hiroki, Kumakiri Chikara, Komatsu Naoya, Iyo Masaomi, Protective effect of LY379268, a selective group II metabotropic glutamate receptor agonist, on dizocilpine-induced neuropathological changes in rat retrosplenial cortex, Brain Research, 992, 1, 2003. Crossref
-
Stone Trevor W, Inhibitors of the kynurenine pathway, European Journal of Medicinal Chemistry, 35, 2, 2000. Crossref
-
Breese George R, Knapp Darin J, Moy Sheryl S, Integrative role for serotonergic and glutamatergic receptor mechanisms in the action of NMDA antagonists: potential relationships to antipsychotic drug actions on NMDA antagonist responsiveness, Neuroscience & Biobehavioral Reviews, 26, 4, 2002. Crossref
-
McAllister K. A. L., Mar A. C., Theobald D. E., Saksida L. M., Bussey T. J., Comparing the effects of subchronic phencyclidine and medial prefrontal cortex dysfunction on cognitive tests relevant to schizophrenia, Psychopharmacology, 232, 21-22, 2015. Crossref
-
Stone Trevor W, Development and therapeutic potential of kynurenic acid and kynurenine derivatives for neuroprotection, Trends in Pharmacological Sciences, 21, 4, 2000. Crossref
-
Nai Qiang, Li Shupeng, Wang Szu-Han, Liu Jing, Lee Frank J.S., Frankland Paul W., Liu Fang, Uncoupling the D1-N-Methyl-D-Aspartate (NMDA) Receptor Complex Promotes NMDA-Dependent Long-Term Potentiation and Working Memory, Biological Psychiatry, 67, 3, 2010. Crossref
-
Moore Holly, Jentsch J. David, Ghajarnia Mehdi, Geyer Mark A., Grace Anthony A., A Neurobehavioral Systems Analysis of Adult Rats Exposed to Methylazoxymethanol Acetate on E17: Implications for the Neuropathology of Schizophrenia, Biological Psychiatry, 60, 3, 2006. Crossref
-
Martins-de-Souza Daniel, Schmitt Andrea, Röder Ruth, Lebar Maria, Schneider-Axmann Thomas, Falkai Peter, Turck Christoph W., Sex-specific proteome differences in the anterior cingulate cortex of schizophrenia, Journal of Psychiatric Research, 44, 14, 2010. Crossref
-
Zuckerman Lee, Weiner Ina, Maternal immune activation leads to behavioral and pharmacological changes in the adult offspring, Journal of Psychiatric Research, 39, 3, 2005. Crossref
-
Bujas-Bobanovic Maja, Robertson Harold A, Dursun Serdar M, Effects of nitric oxide synthase inhibitor NG-nitro-l-arginine methyl ester on phencyclidine-induced effects in rats, European Journal of Pharmacology, 409, 1, 2000. Crossref
-
Jardemark K.E, Liang X, Arvanov V, Wang R.Y, Subchronic treatment with either clozapine, olanzapine or haloperidol produces a hyposensitive response of the rat cortical cells to N-methyl-d-aspartate, Neuroscience, 100, 1, 2000. Crossref
-
Stone Trevor W, Kynurenines in the CNS: from endogenous obscurity to therapeutic importance, Progress in Neurobiology, 64, 2, 2001. Crossref
-
Eyjolfsson Elvar M., Brenner Eiliv, Kondziella Daniel, Sonnewald Ursula, Repeated injection of MK801: An animal model of schizophrenia?, Neurochemistry International, 48, 6-7, 2006. Crossref
-
Condray Ruth, Dougherty George G., Keshavan Matcheri S., Reddy Ravinder D., Haas Gretchen L., Montrose Debra M., Matson Wayne R., McEvoy Joseph, Kaddurah-Daouk Rima, Yao Jeffrey K., 3-Hydroxykynurenine and clinical symptoms in first-episode neuroleptic-naive patients with schizophrenia, The International Journal of Neuropsychopharmacology, 14, 06, 2011. Crossref
-
Gécz Jozef, Barnett Shaun, Liu Jianjun, Hollway Georgina, Donnelly Andrew, Eyre Helen, Eshkevari Hadi S., Baltazar Romulo, Grunn Adina, Nagaraja Ramaiah, Gilliam Conrad, Peltonen Leena, Sutherland Grant R., Baron Miron, Mulley John C., Characterization of the Human Glutamate Receptor Subunit 3 Gene (GRIA3), a Candidate for Bipolar Disorder and Nonspecific X-Linked Mental Retardation, Genomics, 62, 3, 1999. Crossref
-
DeLisi Lynn E., A critical overview of recent investigations into the genetics of schizophrenia, Current Opinion in Psychiatry, 12, 1, 1999. Crossref
-
Levkovitz Yechiel, Levi Uri, Braw Yoram, Cohen Hagit, Minocycline, a second-generation tetracycline, as a neuroprotective agent in an animal model of schizophrenia, Brain Research, 1154, 2007. Crossref
-
Adams Barbara W., Moghaddam Bita, Effect of clozapine, haloperidol, or M100907 on phencyclidine-activated glutamate efflux in the prefrontal cortex, Biological Psychiatry, 50, 10, 2001. Crossref
-
Kim Sang-Young, Lee Hyunseung, Kim Hyun-Ju, Bang Eunjung, Lee Sung-Ho, Lee Do-Wan, Woo Dong-Cheol, Choi Chi-Bong, Hong Kwan Soo, Lee Chulhyun, Choe Bo-Young, In vivoandex vivoevidence for ketamine-induced hyperglutamatergic activity in the cerebral cortex of the rat: Potential relevance to schizophrenia, NMR in Biomedicine, 24, 10, 2011. Crossref
-
Billingslea Eddie N, Mastropaolo John, Rosse Richard B, Bellack Alan S, Deutsch Stephen I, Interaction of stress and strain on glutamatergic neurotransmission: relevance to schizophrenia, Pharmacology Biochemistry and Behavior, 74, 2, 2003. Crossref
-
Turgeon Sarah M, Auerbach Eliza A, Duncan-Smith Megan K, George Jonathan R, Graves William W, The Delayed Effects of DTG and MK-801 on Latent Inhibition in a Conditioned Taste-Aversion Paradigm, Pharmacology Biochemistry and Behavior, 66, 3, 2000. Crossref
-
Steward Lucinda J., Kennedy Matthew D., Morris Brian J., Pratt Judith A., The atypical antipsychotic drug clozapine enhances chronic PCP-induced regulation of prefrontal cortex 5-HT2A receptors, Neuropharmacology, 47, 4, 2004. Crossref
-
Barbon Alessandro, Fumagalli Fabio, La Via Luca, Caracciolo Luca, Racagni Giorgio, Andrea Riva Marco, Barlati Sergio, Chronic phencyclidine administration reduces the expression and editing of specific glutamate receptors in rat prefrontal cortex, Experimental Neurology, 208, 1, 2007. Crossref
-
Nudmamud Sutisa, Reynolds Gavin P, Increased density of glutamate/N-methyl-d-aspartate receptors in superior temporal cortex in schizophrenia, Neuroscience Letters, 304, 1-2, 2001. Crossref
-
Pantazopoulos Harry, Berretta Sabina, In Sickness and in Health: Perineuronal Nets and Synaptic Plasticity in Psychiatric Disorders, Neural Plasticity, 2016, 2016. Crossref
-
Henson Maile A., Roberts Adam C., Pérez-Otaño Isabel, Philpot Benjamin D., Influence of the NR3A subunit on NMDA receptor functions, Progress in Neurobiology, 91, 1, 2010. Crossref
-
Jann Michael W., Implications for Atypical Antipsychotics in the Treatment of Schizophrenia: Neurocognition Effects and a Neuroprotective Hypothesis, Pharmacotherapy, 24, 12, 2004. Crossref
-
Okamura Naoe, Hashimoto Kenji, Kanahara Nobuhisa, Shimizu Eiji, Kumakiri Chikara, Komatsu Naoya, Iyo Masaomi, Protective effect of the antipsychotic drug zotepine on dizocilpine-induced neuropathological changes in rat retrosplenial cortex, European Journal of Pharmacology, 461, 2-3, 2003. Crossref
-
Selemon Lynn D., Lidow Michael S., Goldman-Rakic Patricia S., Increased volume and glial density in primate prefrontal cortex associated with chronic antipsychotic drug exposure, Biological Psychiatry, 46, 2, 1999. Crossref
-
Schwarcz Robert, Rassoulpour Arash, Wu Hui-Qiu, Medoff Deborah, Tamminga Carol A, Roberts Rosalinda C, Increased cortical kynurenate content in schizophrenia, Biological Psychiatry, 50, 7, 2001. Crossref
-
Kubicki M., Park H., Westin C.F., Nestor P.G., Mulkern R.V., Maier S.E., Niznikiewicz M., Connor E.E., Levitt J.J., Frumin M., Kikinis R., Jolesz F.A., McCarley R.W., Shenton M.E., DTI and MTR abnormalities in schizophrenia: Analysis of white matter integrity, NeuroImage, 26, 4, 2005. Crossref
-
Amitai Nurith, Markou Athina, Effects of metabotropic glutamate receptor 2/3 agonism and antagonism on schizophrenia-like cognitive deficits induced by phencyclidine in rats, European Journal of Pharmacology, 639, 1-3, 2010. Crossref
-
Homayoun Houman, Moghaddam Bita, Group 5 metabotropic glutamate receptors: Role in modulating cortical activity and relevance to cognition, European Journal of Pharmacology, 639, 1-3, 2010. Crossref
-
Hashimoto Kenji, Engberg Göran, Shimizu Eiji, Nordin Conny, Lindström Leif H., Iyo Masaomi, Reduced d-serine to total serine ratio in the cerebrospinal fluid of drug naive schizophrenic patients, Progress in Neuro-Psychopharmacology and Biological Psychiatry, 29, 5, 2005. Crossref
-
Stefani Mark R., Moghaddam Bita, Activation of type 5 metabotropic glutamate receptors attenuates deficits in cognitive flexibility induced by NMDA receptor blockade, European Journal of Pharmacology, 639, 1-3, 2010. Crossref
-
Richardson-Burns Sarah M, Haroutunian Vahram, Davis Kenneth L, Watson Stanley J, Meador-Woodruff James H, Metabotropic glutamate receptor mRNA expression in the schizophrenic thalamus, Biological Psychiatry, 47, 1, 2000. Crossref
-
Liu F., Zou X., Sadovova N., Zhang X., Shi L., Guo L., Qian F., Wen Z., Patterson T.A., Hanig J.P., Paule M.G., Slikker W., Wang C., Changes in gene expression after phencyclidine administration in developing rats: a potential animal model for schizophrenia, International Journal of Developmental Neuroscience, 29, 3, 2011. Crossref
-
Wu Hui-Qiu, Lee Song-Chu, Schwarcz Robert, Systemic administration of 4-chlorokynurenine prevents quinolinate neurotoxicity in the rat hippocampus, European Journal of Pharmacology, 390, 3, 2000. Crossref
-
Marksteiner J, Weiss U, Weis C, Laslop A, Fischer-Colbrie R, Humpel C, Feldon J, Fleischhacker W.W, Differential regulation of chromogranin A, chromogranin B and secretogranin II in rat brain by phencyclidine treatment, Neuroscience, 104, 2, 2001. Crossref
-
Sharp Frank R., Hendren Robert L., Psychosis: Atypical limbic epilepsy versus limbic hyperexcitability with onset at puberty?, Epilepsy & Behavior, 10, 4, 2007. Crossref
-
Mohn Amy R, Gainetdinov Raul R, Caron Marc G, Koller Beverly H, Mice with Reduced NMDA Receptor Expression Display Behaviors Related to Schizophrenia, Cell, 98, 4, 1999. Crossref
-
Lara D.R., Souza D.O., Schizophrenia: a purinergic hypothesis, Medical Hypotheses, 54, 2, 2000. Crossref
-
Tomitaka Midori, Tomitaka Shinichiro, Rajdev Sunita, Sharp Frank R, Fluoxetine prevents PCP- and MK801-induced HSP70 expression in injured limbic cortical neurons of rats, Biological Psychiatry, 47, 9, 2000. Crossref
-
Basińska-Starzycka Anna, Pascual-Marqui Roberto Domingo, Dysfunctional prefrontal attention-related resources in schizophrenia localised by the low-resolution electromagnetic tomography (LORETA), International Congress Series, 1232, 2002. Crossref
-
Kalinichev Mikhail, Robbins Melanie J., Hartfield Elizabeth M., Maycox Peter R., Moore Susan H., Savage Kevin M., Austin Nigel E., Jones Declan N.C., Comparison between intraperitoneal and subcutaneous phencyclidine administration in Sprague–Dawley rats: A locomotor activity and gene induction study, Progress in Neuro-Psychopharmacology and Biological Psychiatry, 32, 2, 2008. Crossref
-
Tarazi Frank I., Zhang Kehong, Baldessarini Ross J., Effects of nigrostriatal dopamine denervation on ionotropic glutamate receptors in rat caudate-putamen, Brain Research, 881, 1, 2000. Crossref
-
John John P., Thirunavukkarasu Priyadarshini, Halahalli Harsha N., Purushottam Meera, Jain Sanjeev, A systematic review of the effect of genes mediating neurodevelopment and neurotransmission on brain morphology: Focus on schizophrenia, Neurology, Psychiatry and Brain Research, 21, 1, 2015. Crossref
-
Siuciak Judith A., Chapin Douglas S., McCarthy Sheryl A., Guanowsky Victor, Brown Janice, Chiang Phoebe, Marala Ravi, Patterson Terrell, Seymour Patricia A., Swick Andrew, Iredale Philip A., CP-809,101, a selective 5-HT2C agonist, shows activity in animal models of antipsychotic activity, Neuropharmacology, 52, 2, 2007. Crossref
-
Gainetdinov Raul R, Mohn Amy R, Caron Marc G, Genetic animal models: focus on schizophrenia, Trends in Neurosciences, 24, 9, 2001. Crossref
-
Beraki Simret, Kuzmin Alexander, Tai Fadao, Ögren Sven Ove, Repeated low dose of phencyclidine administration impairs spatial learning in mice: Blockade by clozapine but not by haloperidol, European Neuropsychopharmacology, 18, 7, 2008. Crossref
-
Pritchett David, Jagannath Aarti, Brown Laurence A., Tam Shu K. E., Hasan Sibah, Gatti Silvia, Harrison Paul J., Bannerman David M., Foster Russell G., Peirson Stuart N., Mintz Eric M, Deletion of Metabotropic Glutamate Receptors 2 and 3 (mGlu2 & mGlu3) in Mice Disrupts Sleep and Wheel-Running Activity, and Increases the Sensitivity of the Circadian System to Light, PLOS ONE, 10, 5, 2015. Crossref
-
Deutsch Stephen I., Rosse Richard B., Schwartz Barbara L., Mastropaolo John, A Revised Excitotoxic Hypothesis of Schizophrenia: Therapeutic Implications, Clinical Neuropharmacology, 24, 1, 2001. Crossref
-
Bonito-Oliva Alessandra, DuPont Caitlin, Madjid Nather, Ögren Sven Ove, Fisone Gilberto, Involvement of the Striatal Medium Spiny Neurons of the Direct Pathway in the Motor Stimulant Effects of Phencyclidine, International Journal of Neuropsychopharmacology, 2015. Crossref
-
Martí Sylvia Bort, Cichon Sven, Propping Peter, Nöthen Markus, Human metabotropic glutamate receptor 2 gene (GRM2): Chromosomal sublocalization (3p21.1-p21.2) and genomic organization, American Journal of Medical Genetics, 114, 1, 2002. Crossref
-
Finamore Terri L., Seybold Kevin S., Noble Michelle, Port Richard L., Contributions of Hippocampal Cellular Damage and NMDA Receptor Dysfunction to Behavioral Markers of Schizophrenia, International Journal of Neuroscience, 109, 1-2, 2001. Crossref
-
Luoni Alessia, Gass Peter, Brambilla Paolo, Ruggeri Mirella, Riva Marco A., Inta Dragos, Altered expression of schizophrenia-related genes in mice lacking mGlu5 receptors, European Archives of Psychiatry and Clinical Neuroscience, 268, 1, 2018. Crossref
-
Gallinat Jürgen, McMahon Kibby, Kühn Simone, Schubert Florian, Schaefer Martin, Cross-sectional Study of Glutamate in the Anterior Cingulate and Hippocampus in Schizophrenia, Schizophrenia Bulletin, 42, 2, 2016. Crossref
-
Matsuzawa Daisuke, Obata Takayuki, Shirayama Yukihiko, Nonaka Hiroi, Kanazawa Yoko, Yoshitome Eiji, Takanashi Junichi, Matsuda Tsuyoshi, Shimizu Eiji, Ikehira Hiroo, Iyo Masaomi, Hashimoto Kenji, Baune Bernhard, Negative Correlation between Brain Glutathione Level and Negative Symptoms in Schizophrenia: A 3T 1H-MRS Study, PLoS ONE, 3, 4, 2008. Crossref
-
Chen Long, Yang Charles R., Interaction of Dopamine D1 and NMDA Receptors Mediates Acute Clozapine Potentiation of Glutamate EPSPs in Rat Prefrontal Cortex, Journal of Neurophysiology, 87, 5, 2002. Crossref
-
Honey Rebekah A E, Turner Danielle C, Honey Garry D, Sharar Sam R, Kumaran D, Pomarol-Clotet E, McKenna P, Sahakian B J, Robbins T W, Fletcher P C, Subdissociative Dose Ketamine Produces a Deficit in Manipulation but not Maintenance of the Contents of Working Memory, Neuropsychopharmacology, 28, 11, 2003. Crossref
-
Cochran Susan M, Kennedy Matthew, McKerchar Clare E, Steward Lucinda J, Pratt Judith A, Morris Brian J, Induction of Metabolic Hypofunction and Neurochemical Deficits after Chronic Intermittent Exposure to Phencyclidine: Differential Modulation by Antipsychotic Drugs, Neuropsychopharmacology, 28, 2, 2003. Crossref
-
Rassoulpour Arash, Wu Hui-Qiu, Albuquerque Edson X, Schwarcz Robert, Prolonged Nicotine Administration Results in Biphasic, Brain-Specific Changes in Kynurenate Levels in the Rat, Neuropsychopharmacology, 30, 4, 2005. Crossref
-
Harrison PJ, Lyon L., Sartorius LJ, Burnet Pwj, Lane TA, Review: The group II metabotropic glutamate receptor 3 (mGluR3, mGlu3, GRM3): expression, function and involvement in schizophrenia, Journal of Psychopharmacology, 22, 3, 2008. Crossref
-
Pratt Judith A, Morris Brian J, The thalamic reticular nucleus: A functional hub for thalamocortical network dysfunction in schizophrenia and a target for drug discovery, Journal of Psychopharmacology, 29, 2, 2015. Crossref
-
Bray Nicholas J., Preece Anna, Williams Nigel M., Moskvina Valentina, Buckland Paul R., Owen Michael J., O'Donovan Michael C., Haplotypes at the dystrobrevin binding protein 1 (DTNBP1) gene locus mediate risk for schizophrenia through reduced DTNBP1 expression, Human Molecular Genetics, 14, 14, 2005. Crossref
-
Carfagno Michelle L, Hoskins Lauren A, Pinto Marie E, Yeh Joanne C, Raffa Robert B, Indirect Modulation of Dopamine D2 Receptors as Potential Pharmacotherapy for Schizophrenia: II. Glutamate (Ant)Agonists, Annals of Pharmacotherapy, 34, 6, 2000. Crossref
-
Tao Rui, Auerbach Sidney B., Regulation of serotonin release by GABA and excitatory amino acids, Journal of Psychopharmacology, 14, 2, 2000. Crossref
-
Drapalski Amy L., Rosse Richard B., Peebles Roger R., Schwartz Barbara L., Marvel Cherie L., Deutsch Stephen I., Topiramate Improves Deficit Symptoms in a Patient with Schizophrenia when Added to a Stable Regimen of Antipsychotic Medication, Clinical Neuropharmacology, 24, 5, 2001. Crossref
-
Amitai Nurith, Powell Susan B., Young Jared W., Phencyclidine increased while isolation rearing did not affect progressive ratio responding in rats: Investigating potential models of amotivation in schizophrenia, Behavioural Brain Research, 364, 2019. Crossref
-
Abdul-Monim Z., Reynolds G. P., Neill J. C., The atypical antipsychotic ziprasidone, but not haloperidol, improves phencyclidine-induced cognitive deficits in a reversal learning task in the rat, Journal of Psychopharmacology, 17, 1, 2003. Crossref
-
Okamura Naoe, Hashimoto Kenji, Shimizu Eiji, Kumakiri Chikara, Komatsu Naoya, Iyo Masaomi, Adenosine A1 Receptor Agonists Block the Neuropathological Changes in Rat Retrosplenial Cortex after Administration of the NMDA Receptor Antagonist Dizocilpine, Neuropsychopharmacology, 29, 3, 2004. Crossref
-
Chen Long, Muhlhauser Mark, Yang Charles R., Glycine Tranporter-1 Blockade Potentiates NMDA-Mediated Responses in Rat Prefrontal Cortical Neurons In Vitro and In Vivo, Journal of Neurophysiology, 89, 2, 2003. Crossref
-
Dursun S. M., Deakin J. F. W., Augmenting antipsychotic treatment with lamotrigine or topiramate in patients with treatment-resistant schizophrenia: a naturalistic caseseries outcome study, Journal of Psychopharmacology, 15, 4, 2001. Crossref
-
Gadelha Ary, Zugman André, Calzavara Mariana Bendlin, de Mendonça Furtado Remo Holanda, Scorza Fulvio Alexandre, Bressan Rodrigo Afonsecca, Is adenosine associated with sudden death in schizophrenia? A new framework linking the adenosine pathway to risk of sudden death, Neuroscience & Biobehavioral Reviews, 84, 2018. Crossref
-
Kobayashi Yuka, DNA microarray unravels rapid changes in transcriptome of MK-801 treated rat brain, World Journal of Biological Chemistry, 6, 4, 2015. Crossref
-
Flores Cecilia, Coyle Joseph T, Regulation of Glutamate Carboxypeptidase II Function in Corticolimbic Regions of Rat Brain by Phencyclidine, Haloperidol, and Clozapine, Neuropsychopharmacology, 28, 7, 2003. Crossref
-
Takahata Ryuichi, Moghaddam Bita, Activation of Glutamate Neurotransmission in the Prefrontal Cortex Sustains the Motoric and Dopaminergic Effects of Phencyclidine, Neuropsychopharmacology, 28, 6, 2003. Crossref
-
Kajimoto Yasuo, Shirakawa Osamu, Lin Xian-Hao, Hashimoto Takeshi, Kitamura Noboru, Murakami Naoya, Takumi Toru, Maeda Kiyoshi, Synapse-Associated Protein 90/Postsynaptic Density-95-Associated Protein (SAPAP) is Expressed Differentially in Phencyclidine-Treated Rats and is Increased in the Nucleus Accumbens of Patients with Schizophrenia, Neuropsychopharmacology, 28, 10, 2003. Crossref
-
Adams Barbara W., Bradberry Charles W., Moghaddam Bita, NMDA antagonist effects on striatal dopamine release: Microdialysis studies in awake monkeys, Synapse, 43, 1, 2002. Crossref
-
Jardemark Kent E., Ai Jinglu, Ninan Ipe, Wang Rex Y., Biphasic modulation of NMDA-induced responses in pyramidal cells of the medial prefrontal cortex by Y-931, a potential atypical antipsychotic drug, Synapse, 41, 4, 2001. Crossref
-
Honey R A E, Honey G D, O'Loughlin C, Sharar S R, Kumaran D, Bullmore E T, Menon D K, Donovan T, Lupson V C, Bisbrown-Chippendale R, Fletcher P C, Acute Ketamine Administration Alters the Brain Responses to Executive Demands in a Verbal Working Memory Task: an fMRI Study, Neuropsychopharmacology, 29, 6, 2004. Crossref
-
Sun Min-Yu, Izumi Yukitoshi, Benz Ann, Zorumski Charles F., Mennerick Steven, Endogenous 24S-hydroxycholesterol modulates NMDAR-mediated function in hippocampal slices, Journal of Neurophysiology, 115, 3, 2016. Crossref
-
Tajiri Koji, Emori Kenji, Murata Masahiko, Tanaka Kodai, Suzuki Michio, Uehara Takashi, Sumiyoshi Tomiki, Ashby Charles R., Kurachi Masayoshi, Intracerebroventricular administration of NMDA-R1 antisense oligodeoxynucleotide significantly alters the activity of ventral tegmental area dopamine neurons: An electrophysiological study, Synapse, 40, 4, 2001. Crossref
-
Kavalali Ege T., Synaptic Vesicle Reuse and Its Implications, The Neuroscientist, 12, 1, 2006. Crossref
-
Homayoun Houman, Stefani Mark R, Adams Barbara W, Tamagan Gilles D, Moghaddam Bita, Functional Interaction Between NMDA and mGlu5 Receptors: Effects on Working Memory, Instrumental Learning, Motor Behaviors, and Dopamine Release, Neuropsychopharmacology, 29, 7, 2004. Crossref
-
Harrison Paul J., The neuropathology of schizophrenia, Brain, 122, 4, 1999. Crossref
-
Deutsch Stephen I., Schwartz Barbara L., Rosse Richard B., Mastropaolo John, Marvel Cherie L., Drapalski Amy L., Adjuvant Topiramate Administration: A Pharmacologic Strategy for Addressing NMDA Receptor Hypofunction in Schizophrenia, Clinical Neuropharmacology, 26, 4, 2003. Crossref
-
Wood Christian M., Wafford Keith A., McCarthy Andrew P., Hewes Nicola, Shanks Elaine, Lodge David, Robinson Emma S.J., Investigating the role of mGluR2 versus mGluR3 in antipsychotic-like effects, sleep-wake architecture and network oscillatory activity using novel Han Wistar rats lacking mGluR2 expression, Neuropharmacology, 140, 2018. Crossref
-
Tsapakis Eva M., Travis Michael J., Glutamate and psychiatric disorders, Advances in Psychiatric Treatment, 8, 3, 2002. Crossref
-
Tamminga Carol, Glutamatergic aspects of schizophrenia, British Journal of Psychiatry, 174, S37, 1999. Crossref
-
Bhriain S. Ni, Clare A. W., Lawlor B. A., Neuroimaging: a new training issue in psychiatry?, Psychiatric Bulletin, 29, 5, 2005. Crossref
-
Burk Joshua A., Blumenthal Sarah A., Maness Eden B., Neuropharmacology of attention, European Journal of Pharmacology, 835, 2018. Crossref
-
Murphy Emily R., Dalley Jeffrey W., Robbins Trevor W., Local glutamate receptor antagonism in the rat prefrontal cortex disrupts response inhibition in a visuospatial attentional task, Psychopharmacology, 179, 1, 2005. Crossref
-
Le Corre Sylvie, Harper Clive G., Lopez Pilar, Ward Philip, Catts Stanley, Increased levels of expression of an NMDAR1 splice variant in the superior temporal gyrus in schizophrenia, NeuroReport, 11, 5, 2000. Crossref
-
Thaker Gunvant K., Carpenter William T., Advances in schizophrenia, Nature Medicine, 7, 6, 2001. Crossref
-
Cochran Susan M., Fujimura Masatake, Morris Brian J., Pratt Judith A., Acute and delayed effects of phencyclidine upon mRNA levels of markers of glutamatergic and GABAergic neurotransmitter function in the rat brain, Synapse, 46, 3, 2002. Crossref
-
Marek Gerard J., Behl Berthold, Bespalov Anton Y., Gross Gerhard, Lee Younglim, Schoemaker Hans, Glutamatergic (N-Methyl-d-aspartate Receptor) Hypofrontality in Schizophrenia: Too Little Juice or a Miswired Brain?, Molecular Pharmacology, 77, 3, 2010. Crossref
-
Matveeva Tatyana M., Pisansky Marc T., Young Amy, Miller Robert F., Gewirtz Jonathan C., Sociality deficits in serine racemase knockout mice, Brain and Behavior, 9, 10, 2019. Crossref
-
Auerbach Sidney B., Regulation of serotonin release by inhibitory and excitatory amino acids, in Serotonin and Sleep: Molecular, Functional and Clinical Aspects, 2008. Crossref
-
Tamminga C. A., Lahti A. C., Medoff D. R., Holcomb H. H., Die funktionelle Beteiligung des vorderen zingulären Kortex an der schizophrenen Psychose, in Psychiatrie der Gegenwart 5, 2000. Crossref
-
Lieberman Jeffrey A., Bymaster Frank P., Meltzer Herbert Y., Deutch Ariel Y., Duncan Gary E., Marx Christine E., Aprille June R., Dwyer Donard S., Li Xin-Min, Mahadik Sahebarao P., Duman Ronald S., Porter Joseph H., Modica-Napolitano Josephine S., Newton Samuel S., Csernansky John G., Antipsychotic Drugs: Comparison in Animal Models of Efficacy, Neurotransmitter Regulation, and Neuroprotection, Pharmacological Reviews, 60, 3, 2008. Crossref
-
Klivényi Péter, Toldi József, Vécsei László, Kynurenines in Neurodegenerative Disorders: Therapeutic Consideration, in Frontiers in Clinical Neuroscience, 541, 2004. Crossref
-
Wolf R., Pharmakologische Beeinflussbarkeit von Verhaltensparametern in genetischen und Läsions-induzierten Tiermodellen der Schizophrenie, in Universitätskolloquien zur Schizophrenie, 2004. Crossref
-
Chen Yue, Spatial integration in perception and cognition: An empirical approach to the pathophysiology of schizophrenia, Behavioral and Brain Sciences, 26, 1, 2003. Crossref
-
Condray Ruth, Steinhauer Stuart R., Mechanisms of disrupted language comprehension in schizophrenia, Behavioral and Brain Sciences, 26, 1, 2003. Crossref
-
Xia Zongqi, Sheffler Douglas J., Roth Bryan L., 5-HT Receptor-Associated Proteins (FRAPs), in The Serotonin Receptors, 2006. Crossref
-
Bressler Steven L., Context rules, Behavioral and Brain Sciences, 26, 1, 2003. Crossref
-
Kiss C., Vécsei L., Kynurenines in the Brain: Preclinical and Clinical Studies, Therapeutic Considerations, in Handbook of Neurochemistry and Molecular Neurobiology, 2009. Crossref
-
Barendregt Hendrik Pieter, A wide-spectrum coordination model of schizophrenia, Behavioral and Brain Sciences, 26, 1, 2003. Crossref
-
Barch Deanna M., Braver Todd S., Where the rubber meets the road: The importance of implementation, Behavioral and Brain Sciences, 26, 1, 2003. Crossref
-
Alpert Murray, Angrist Burt, The ketamine model for schizophrenia, Behavioral and Brain Sciences, 26, 1, 2003. Crossref
-
Arai Amy C., Xia Yan-Fang, Kessler Markus, Phillips Dean, Chamberlin Richard, Granger Richard, Lynch Gary, Effects of 5′-Alkyl-Benzothiadiazides on (R,S)-α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Biophysics and Synaptic Responses, Molecular Pharmacology, 62, 3, 2002. Crossref
-
Histology, in The Brain and Behavior, 2005. Crossref
-
Hemsley David R., Schizophrenic cognition: Taken out of context?, Behavioral and Brain Sciences, 26, 1, 2003. Crossref
-
Limbic system: temporal lobe, in The Brain and Behavior, 2005. Crossref
-
Grossberg Stephen, Linking brain to mind in normal behavior and schizophrenia, Behavioral and Brain Sciences, 26, 1, 2003. Crossref
-
Limbic system: overview, in The Brain and Behavior, 2005. Crossref
-
Gooding Diane C., Braun Jacqueline G., Cognitive coordination deficits: A necessary but not sufficient factor in the development of schizophrenia, Behavioral and Brain Sciences, 26, 1, 2003. Crossref
-
Enomoto Takeshi, Noda Yukihiro, Mouri Akihiro, Shin Eun-Joo, Wang Dayong, Murai Rina, Hotta Kazuo, Furukawa Hiroshi, Nitta Atsumi, Kim Hyoung-Chun, Nabeshima Toshitaka, Long-Lasting Impairment of Associative Learning Is Correlated with a Dysfunction of N-Methyl-d-aspartate-Extracellular Signaling-Regulated Kinase Signaling in Mice after Withdrawal from Repeated Administration of Phencyclidine, Molecular Pharmacology, 68, 6, 2005. Crossref
-
Suzuki Katsuaki, Nakamura Kazuhiko, Iwata Yasuhide, Sekine Yoshimoto, Kawai Masayoshi, Sugihara Genichi, Tsuchiya Kenji J., Suda Shiro, Matsuzaki Hideo, Takei Nori, Hashimoto Kenji, Mori Norio, Decreased expression of reelin receptor VLDLR in peripheral lymphocytes of drug-naive schizophrenic patients, Schizophrenia Research, 98, 1-3, 2008. Crossref
-
Ginsberg J. P., Setting domain boundaries for convergence of biological and psychological perspectives on cognitive coordination in schizophrenia, Behavioral and Brain Sciences, 26, 1, 2003. Crossref
-
Alves Óscar L., Bullock Ross, Excitotoxic Damage in Traumatic Brain Injury, in Brain Injury, 2001. Crossref
-
Skaper Stephen D., Phosphatidylinositol 3-Kinase/Glycogen Synthase Kinase and Mitogen-Activated Protein Kinase Signalling Cascades in Neuronal Cell Survival: What the Neurotrophins Have Taught Us and Implications For Neuropsychiatric Disorders, in Brain Protection in Schizophrenia, Mood and Cognitive Disorders, 2010. Crossref
-
Ganel R., Rothstein J. D., Glutamate Transporter Dysfunction and Neuronal Death, in Ionotropic Glutamate Receptors in the CNS, 141, 1999. Crossref
-
Kristiansen L. V., Cowell R. M., Biscaia M., McCullumsmith R. E., Meador-Woodruff J. H., Alterations of Neurotransmitter Receptors in Schizophrenia: Evidence from Postmortem Studies, in Handbook of Neurochemistry and Molecular Neurobiology, 2009. Crossref
-
Tagamets M.-A., Horwitz Barry, Synchronous dynamics for cognitive coordination: But how?, Behavioral and Brain Sciences, 26, 1, 2003. Crossref
-
Strelets Valeria, Cortical connectivity in high-frequency beta-rhythm in schizophrenics with positive and negative symptoms, Behavioral and Brain Sciences, 26, 1, 2003. Crossref
-
Sass Louis A., Uhlhaas Peter J., Phenomenology, context, and self-experience in schizophrenia, Behavioral and Brain Sciences, 26, 1, 2003. Crossref
-
Sanders Glenn S., Platek Steven M., Gallup Gordon G., No blind schizophrenics: Are NMDA-receptor dynamics involved?, Behavioral and Brain Sciences, 26, 1, 2003. Crossref
-
Guitart Xavier, σ Receptors and Scizophrenia, in Sigma Receptors, 2007. Crossref
-
Stevens Janice R., Schizophrenia: developmental, degenerative or both?, in Search for the Causes of Schizophrenia, 2004. Crossref
-
Young Jared W., Zhou Xianjin, Geyer Mark A., Animal Models of Schizophrenia, in Behavioral Neurobiology of Schizophrenia and Its Treatment, 4, 2010. Crossref
-
Silverstein Steven M., Phillips William A., Cognitive coordination and its neurobiological bases: A new continent to explore, Behavioral and Brain Sciences, 26, 1, 2003. Crossref
-
Williams Leanne M., Lee Kwang-Hyuk, Haig Albert, Gordon Evian, High-frequency synchronisation in schizophrenia: Too much or too little?, Behavioral and Brain Sciences, 26, 1, 2003. Crossref
-
Titone Debra, Debruille J. Bruno, Guarding against over-inclusive notions of “context”: Psycholinguistic and electrophysiological studies of specific context functions in schizophrenia, Behavioral and Brain Sciences, 26, 1, 2003. Crossref
-
Jane D. E., Tse H. W., Skifter D. A., Christie J. M., Monaghan D. T., Glutamate Receptor Ion Channels: Activators and Inhibitors, in Pharmacology of Ionic Channel Function: Activators and Inhibitors, 147, 2000. Crossref
-
Talamini L. M., Meeter M., Murre J. M. J., Combating fuzziness with computational modeling, Behavioral and Brain Sciences, 26, 1, 2003. Crossref
-
MacDonald Angus W., Reconciling schizophrenic deficits in top-down and bottom-up processes: Not yet, Behavioral and Brain Sciences, 26, 1, 2003. Crossref
-
Leiser David, Bonshtein Udi, Theory of mind in schizophrenia: Damaged module or deficit in cognitive coordination?, Behavioral and Brain Sciences, 26, 1, 2003. Crossref
-
Hayashi Teruo, Su Tsung-Ping, ??-1 Receptor Ligands, CNS Drugs, 18, 5, 2004. Crossref
-
Kindlundh-Högberg Anna MS, Blomqvist Anna, Malki Rana, Schiöth Helgi B, Extensive neuroadaptive changes in cortical gene-transcript expressions of the glutamate system in response to repeated intermittent MDMA administration in adolescent rats, BMC Neuroscience, 9, 1, 2008. Crossref
-
Kisley Michael A., Davalos Deana B., Is sensory gating a form of cognitive coordination?, Behavioral and Brain Sciences, 26, 1, 2003. Crossref
-
Javitt Daniel C., Peeling the onion: NMDA dysfunction as a unifying model in schizophrenia, Behavioral and Brain Sciences, 26, 1, 2003. Crossref
-
Hoffman Ralph E., McGlashan Thomas H., NMDA-receptor hypofunction versus excessive synaptic elimination as models of schizophrenia, Behavioral and Brain Sciences, 26, 1, 2003. Crossref
-
Roelfsema Pieter R., Supèr Hans, Why do schizophrenic patients hallucinate?, Behavioral and Brain Sciences, 26, 1, 2003. Crossref
-
Raffone Antonino, Murre Jaap M. J., Wolters Gezinus, NMDA synapses can bias competition between object representations and mediate attentional selection, Behavioral and Brain Sciences, 26, 1, 2003. Crossref
-
Pflieger Mark E., Inferring contextual field interactions from scalp EEG, Behavioral and Brain Sciences, 26, 1, 2003. Crossref
-
Park Sohee, Lee Junghee, Folley Bradley, Kim Jejoong, Schizophrenia: Putting context in context, Behavioral and Brain Sciences, 26, 1, 2003. Crossref
-
Gareri Pietro, De Fazio Pasquale, Stilo Mariagrazia, Ferreri Guido, De Sarro Giovambattista, Conventional and Atypical Antipsychotics in the Elderly, Clinical Drug Investigation, 23, 5, 2003. Crossref
-
Oades Robert D., Röpcke Bernd, Oknina Ljubov, Context, connection, and coordination: The need to switch, Behavioral and Brain Sciences, 26, 1, 2003. Crossref
-
Mendoza John E., Foundas Anne L., Neurochemical Transmission, in Clinical Neuroanatomy: A Neurobehavioral Approach, 2008. Crossref
-
Tamminga Carol A., Medoff Deborah C., Thaker Gunvant, Schizophrenia, in Principles of Molecular Medicine, 2006. Crossref
-
Benes Francine M., Berretta Sabina, Defining the Role of Specific Limbic Circuitry in the Pathophysiology of Schizophrenia and Bipolar Disorder, in The Postmortem Brain in Psychiatric Research, 4, 2002. Crossref
-
Kemp John A., McKernan Ruth M., NMDA receptor pathways as drug targets, Nature Neuroscience, 5, S11, 2002. Crossref
-
Tamminga C. A., Lahti A. C., Medoff D. R., Holcomb H. H., The Functional Involvement of the Anterior Cingulate Cortex in Schizophrenic Psychosis, in Contemporary Psychiatry, 2001. Crossref
-
Atkinson B. N., Bell S. C., De Vivo M., Kowalski L. R., Lechner S. M., Ognyanov V. I., Tham C.-S., Tsai C., Jia J., Ashton D., Klitenick M. A., ALX 5407: A Potent, Selective Inhibitor of the hGlyT1 Glycine Transporter, Molecular Pharmacology, 60, 6, 2001. Crossref
-
Keshavan Matcheri S., Cornblatt Barbara A., Developmental models and hypothesis-driven early interventions in schizophrenia, in Neurodevelopment and Schizophrenia, 2004. Crossref
-
Wang Jing, Yu Wenwen, Gao Qin, Ju Chuanxia, Wang KeWei, Prefrontal inhibition of neuronal K v 7 channels enhances prepulse inhibition of acoustic startle reflex and resistance to hypofrontality , British Journal of Pharmacology, 177, 20, 2020. Crossref
-
Nawaz Rukhsana, Gul Saima, Amin Rafat, Huma Tanzeel, Al Mughairbi Fadwa, Overview of schizophrenia research and treatment in Pakistan, Heliyon, 6, 11, 2020. Crossref
-
Cioffi Christopher L., Liu Shuang, Wolf Mark A., Guzzo Peter R., Sadalapure Kashinath, Parthasarathy Visweswaran, Loong David T. J., Maeng Jun-Ho, Carulli Edmund, Fang Xiao, Karunakaran Kalesh, Matta Lakshman, Choo Sok Hui, Panduga Shailijia, Buckle Ronald N., Davis Randall N., Sakwa Samuel A., Gupta Priya, Sargent Bruce J., Moore Nicholas A., Luche Michele M., Carr Grant J., Khmelnitsky Yuri L., Ismail Jiffry, Chung Mark, Bai Mei, Leong Wei Yee, Sachdev Nidhi, Swaminathan Srividya, Mhyre Andrew J., Synthesis and Biological Evaluation ofN-((1-(4-(Sulfonyl)piperazin-1-yl)cycloalkyl)methyl)benzamide Inhibitors of Glycine Transporter-1, Journal of Medicinal Chemistry, 59, 18, 2016. Crossref
-
Schauz Cornelia, Koch Michael, Blockade of NMDA Receptors in the Amygdala Prevents Latent Inhibition of Fear-Conditioning, Learning & Memory, 7, 6, 2000. Crossref
-
Han Zhengrong, Chai Weitai, Wang Zhuo, Xiao Fangyan, Dai Jiapei, Quantum energy levels of glutamate modulate neural biophotonic signals, Photochemical & Photobiological Sciences, 20, 3, 2021. Crossref
-
Tanra Andi Jayalangkara, Sabaruddin Herwina, Liaury Kristian , Zainuddin Andi Alfian , Effect of Adjuvant Vitamin C on Brain-Derived Neurotrophic Factor Levels and Improvement of Negative Symptoms in Schizophrenic Patients, Open Access Macedonian Journal of Medical Sciences, 9, T3, 2021. Crossref
-
Moon Sun-Young, Kim Minah, Lho Silvia Kyungjin, Oh Sanghoon, Kim Se Hyun, Kwon Jun Soo, Systematic Review of the Neural Effect of Electroconvulsive Therapy in Patients with Schizophrenia: Hippocampus and Insula as the Key Regions of Modulation, Psychiatry Investigation, 18, 6, 2021. Crossref
-
Stone Trevor W., Relationships and Interactions between Ionotropic Glutamate Receptors and Nicotinic Receptors in the CNS, Neuroscience, 468, 2021. Crossref
-
Bräuner-Osborne Hans, Egebjerg Jan, Nielsen Elsebet Ø., Madsen Ulf, Krogsgaard-Larsen Povl, Ligands for Glutamate Receptors: Design and Therapeutic Prospects, Journal of Medicinal Chemistry, 43, 14, 2000. Crossref
-
Rammsayer Thomas H., Effects of Pharmacologically Induced Changes in NMDA-Receptor Activity on Long-Term Memory in Humans, Learning & Memory, 8, 1, 2001. Crossref
-
Ibrahim Hisham M., Tamminga Carol A., Schizophrenia: Treatment Targets Beyond Monoamine Systems, Annual Review of Pharmacology and Toxicology, 51, 1, 2011. Crossref
-
Wesseling Hendrik, Guest Paul C, Lee Chi-Ming, Wong Erik HF, Rahmoune Hassan, Bahn Sabine, Integrative proteomic analysis of the NMDA NR1 knockdown mouse model reveals effects on central and peripheral pathways associated with schizophrenia and autism spectrum disorders, Molecular Autism, 5, 1, 2014. Crossref
-
Liao Lujian, Sando Richard C., Farnum John B., Vanderklish Peter W., Maximov Anton, Yates John R., 15N-Labeled Brain Enables Quantification of Proteome and Phosphoproteome in Cultured Primary Neurons, Journal of Proteome Research, 11, 2, 2012. Crossref
-
Rowley Michael, Bristow Linda J., Hutson Peter H., Current and Novel Approaches to the Drug Treatment of Schizophrenia, Journal of Medicinal Chemistry, 44, 4, 2001. Crossref
-
Moghaddam Bita, Adams Barbara W., Reversal of Phencyclidine Effects by a Group II Metabotropic Glutamate Receptor Agonist in Rats, Science, 281, 5381, 1998. Crossref
-
Nilsson L. K., Linderholm K. R., Erhardt S., Subchronic treatment with kynurenine and probenecid: effects on prepulse inhibition and firing of midbrain dopamine neurons, Journal of Neural Transmission, 113, 5, 2006. Crossref
-
Hashimoto Kenji, Sawa Akira, Iyo Masaomi, Increased Levels of Glutamate in Brains from Patients with Mood Disorders, Biological Psychiatry, 62, 11, 2007. Crossref
-
Harrison P J, Weinberger D R, Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence, Molecular Psychiatry, 10, 1, 2005. Crossref
-
Harrison Paul J., Postmortem studies in schizophrenia, Dialogues in Clinical Neuroscience, 2, 4, 2000. Crossref
-
Abi-Dargham Anissa, Rodenhiser Janine, Printz David, Zea-Ponce Yolanda, Gil Roberto, Kegeles Lawrence S., Weiss Richard, Cooper Thomas B., Mann J. John, Van Heertum Ronald L., Gorman Jack M., Laruelle Marc, Increased baseline occupancy of D 2 receptors by dopamine in schizophrenia , Proceedings of the National Academy of Sciences, 97, 14, 2000. Crossref
-
Wang Ya-Nan, Figueiredo Dwight, Sun Xiang-Dong, Dong Zhao-Qi, Chen Wen-Bing, Cui Wan-Peng, Liu Fang, Wang Hong-Sheng, Li Hai-Wen, Robinson Heath, Fei Er-Kang, Pan Bing-Xing, Li Bao-Ming, Xiong Wen-Cheng, Mei Lin, Controlling of glutamate release by neuregulin3 via inhibiting the assembly of the SNARE complex, Proceedings of the National Academy of Sciences, 115, 10, 2018. Crossref
-
Histology, in The Brain and Behavior, 2010. Crossref
-
Linn Gary S., O’Keeffe Robert T., Lifshitz Kenneth, Schroeder Charles, Javitt Daniel C., Behavioral effects of orally administered glycine in socially housed monkeys chronically treated with phencyclidine, Psychopharmacology, 192, 1, 2007. Crossref
-
Limbic system: Temporal lobe, in The Brain and Behavior, 2010. Crossref
-
Limbic system: Overview, in The Brain and Behavior, 2010. Crossref
-
Marek Gerard J., Kinon Bruce J., McKinzie David L., Schkeryantz Jeffrey M., Monn James A., Metabotropic Glutamate 2/3 Receptor Agonists and Positive Allosteric Modulators of Metabotropic Glutamate Receptor 2 as Novel Agents for the Treatment of Schizophrenia, in Targets and Emerging Therapies for Schizophrenia, 2012. Crossref
-
Scott Lena, Kruse Maria Sol, Forssberg Hans, Brismar Hjalmar, Greengard Paul, Aperia Anita, Selective up-regulation of dopamine D1 receptors in dendritic spines by NMDA receptor activation, Proceedings of the National Academy of Sciences, 99, 3, 2002. Crossref
-
Siuciak Judith A., Chapin Douglas S., McCarthy Sheryl A., Martin Ashley N., Antipsychotic profile of rolipram: efficacy in rats and reduced sensitivity in mice deficient in the phosphodiesterase-4B (PDE4B) enzyme, Psychopharmacology, 192, 3, 2007. Crossref
-
Arranz M J, de Leon J, Pharmacogenetics and pharmacogenomics of schizophrenia: a review of last decade of research, Molecular Psychiatry, 12, 8, 2007. Crossref
-
Shinozaki Naoko, Yabe Hirooki, Sato Yasuharu, Hiruma Tomiharu, Sutoh Takeyuki, Nashida Tadayoshi, Matsuoka Takashi, Kaneko Sunao, The difference in Mismatch negativity between the acute and post-acute phase of schizophrenia, Biological Psychology, 59, 2, 2002. Crossref
-
Kapur S, Seeman P, NMDA receptor antagonists ketamine and PCP have direct effects on the dopamine D2 and serotonin 5-HT2 receptors—implications for models of schizophrenia, Molecular Psychiatry, 7, 8, 2002. Crossref
-
Weiner Ina, Arad Michal, The pharmacology of latent inhibition and its relevance to schizophrenia, in Latent Inhibition, 2010. Crossref
-
Rice S R, Niu N, Berman D B, Heston L L, Sobell J L, Identification of single nucleotide polymorphisms (SNPs) and other sequence changes and estimation of nucleotide diversity in coding and flanking regions of the NMDAR1 receptor gene in schizophrenic patients, Molecular Psychiatry, 6, 3, 2001. Crossref