Abo Bibliothek: Guest
Critical Reviews™ in Neurobiology

Erscheint 3 Ausgaben pro Jahr

ISSN Druckformat: 0892-0915

ISSN Online: 2375-0014

SJR: 0.121

Methylphenidate Treated at the Test Cage—Dose-Dependent Sensitization or Tolerance Depend on the Behavioral Assay Used

Volumen 19, Ausgabe 1, 2007, pp. 59-77
DOI: 10.1615/CritRevNeurobiol.v19.i1.20
Get accessGet access

ABSTRAKT

Methylphenidate is the drug most often used to treat attention deficit/hyperactivity disorder (ADHD), a common behavioral disorder of children and young adults. The objectives of this study are (1) to use two different experimental assays of measuring animal activity— the wheel-running activity and the computerized open field—to establish which is more sensitive to acute and repetitive methylphenidate (MPD) administration and (2) to determine whether repetitive MPD treatment elicits adverse effects such as tolerance and behavioral sensitization. The dose-response protocol of MPD (0.6, 2.5, and 10.0 mg/kg) administration was performed in three groups of animals, with an additional saline control group as follows: single saline injection as the control/baseline followed by 6 consecutive days of MPD injections (0.6, 2.5, or 10.0 mg/kg MPD), 3 days of washout, and a day of MPD rechallenge. In general, the two different activity assays showed similar observations for the acute effect of MPD by eliciting increases in activity in a dose-dependent manner. The groups receiving repetitive 0.6 and 2.5 mg/kg MPD tested in the open-field assay exhibited further increase in activity that can be interpreted as behavioral sensitization, whereas the groups receiving 10 mg/kg MPD exhibited a reduction in activity, suggesting that tolerance was developed to the drug. All the groups (0.6, 2.5, and 10.0 mg/kg MPD) tested following repetitive MPD in the wheel-running assay exhibited a further increase in their activity, for example, all the groups exhibited behavioral sensitization. These different observations were interpreted as potentially measuring different kinds of locomotor activity.

REFERENZIERT VON
  1. Tang Bin, Dafny Nachum, Dorsal raphe neuronal activities are modulated by methylphenidate, Journal of Neural Transmission, 120, 5, 2013. Crossref

  2. Jones Cathleen G., Yang Pamela B., Wilcox Victor T., Burau Keith D., Dafny Nachum, Acute and chronic psychostimulant treatment modulates the diurnal rhythm activity pattern of WKY female adolescent rats, Journal of Neural Transmission, 121, 5, 2014. Crossref

  3. Chong Samuel L., Claussen Catherine M., Dafny Nachum, Nucleus accumbens neuronal activity in freely behaving rats is modulated following acute and chronic methylphenidate administration, Brain Research Bulletin, 87, 4-5, 2012. Crossref

  4. Claussen Catherine M., Chong Samuel L., Dafny Nachum, Nucleus accumbens neuronal activity correlates to the animal's behavioral response to acute and chronic methylphenidate, Physiology & Behavior, 129, 2014. Crossref

  5. Yang P.B., Swann A.C., Dafny N., Psychostimulants given in adolescence modulate their effects in adulthood using the open field and the wheel-running assays, Brain Research Bulletin, 82, 3-4, 2010. Crossref

  6. Lee Min J., Yang Pamela B., Wilcox Victor T., Burau Keith D., Swann Alan C., Dafny Nachum, Does repetitive Ritalin injection produce long-term effects on SD female adolescent rats?, Neuropharmacology, 57, 3, 2009. Crossref

  7. Claussen Catherine M., Dafny Nachum, Caudate neuronal recording in freely behaving animals following acute and chronic dose response methylphenidate exposure, Pharmacology Biochemistry and Behavior, 136, 2015. Crossref

  8. Chelaru Mircea I., Yang Pamela B., Dafny Nachum, Sex differences in the behavioral response to methylphenidate in three adolescent rat strains (WKY, SHR, SD), Behavioural Brain Research, 226, 1, 2012. Crossref

  9. References, in The Science of ADHD, 2010. Crossref

  10. Yang Pamela B., Atkins Kristal D., Dafny Nachum, Behavioral sensitization and cross-sensitization between methylphenidate amphetamine, and 3,4-methylenedioxymethamphetamine (MDMA) in female SD rats, European Journal of Pharmacology, 661, 1-3, 2011. Crossref

  11. Atkins Kristal, Burks Tilithia, Swann Alan C., Dafny Nachum, MDMA (ecstasy) modulates locomotor and prefrontal cortex sensory evoked activity, Brain Research, 1302, 2009. Crossref

  12. Ponchio R.A., Teodorov E., Kirsten T.B., Coelho C.P., Oshiro A., Florio J.C., Bernardi M.M., Repeated methylphenidate administration during lactation reduces maternal behavior, induces maternal tolerance, and increases anxiety-like behavior in pups in adulthood, Neurotoxicology and Teratology, 50, 2015. Crossref

  13. Venkataraman Sidish, Claussen Catherine, Dafny Nachum, D1 and D2 specific dopamine antagonist modulate the caudate nucleus neuronal responses to chronic methylphenidate exposure, Journal of Neural Transmission, 124, 2, 2017. Crossref

  14. Venkataraman Sidish S., Claussen Catherine, Joseph Michael, Dafny Nachum, Concomitant behavioral and PFC neuronal activity recorded following dose-response protocol of MPD in adult male rats, Brain Research Bulletin, 130, 2017. Crossref

  15. Kharas Natasha, Reyes-Vazquez Cruz, Dafny Nachum, Locus coeruleus neuronal activity correlates with behavioral response to acute and chronic doses of methylphenidate (Ritalin) in adolescent rats, Journal of Neural Transmission, 124, 10, 2017. Crossref

  16. Venkataraman Sidish S., Joseph Michael, Dafny Nachum, Concomitant behavioral and prefrontal cortex neuronal responses following acute and chronic methylphenidate exposure in adolescent and adult rats, Brain Research Bulletin, 144, 2019. Crossref

  17. Venkataraman Sidish S., Claussen Catherine M., Kharas Natasha, Dafny Nachum, The prefrontal cortex and the caudate nucleus respond conjointly to methylphenidate (Ritalin). Concomitant behavioral and neuronal recording study, Brain Research Bulletin, 157, 2020. Crossref

  18. Medina A. C., Kabani A., Reyes-Vasquez C., Dafny N., Age differences to methylphenidate-NAc neuronal and behavioral recordings from freely behaving animals, Journal of Neural Transmission, 129, 8, 2022. Crossref

Digitales Portal Digitale Bibliothek eBooks Zeitschriften Referenzen und Berichte Forschungssammlungen Preise und Aborichtlinien Begell House Kontakt Language English 中文 Русский Português German French Spain