RT Journal Article
ID 009987296e8eefdf
A1 Chien, Rao-Chi 
A1 Yang, Yi-Chi
A1 Lai, Eric Icheng
A1 Mau, Jeng-Leun
T1 Anti-Inflammation and Lipogenic Inhibition of <i>Taiwanofungus salmonea</i> Mycelium and <i>Grifola frondosa</i> Fruiting Body
JF International Journal of Medicinal Mushrooms
JO IJM
YR 2017
FD 2017-09-22
VO 19
IS 7
SP 629
OP 640
K1 <i>Grifola frondosa</i>
K1 inflammation
K1 medicinal mushrooms
K1 nonalcoholic steatohepatitis
K1 <i>Taiwanofungus salmonea</i>
AB A long-term inflammatory response can cause the development of nonalcoholic steatohepatitis (NASH), which is mainly caused by abnormal metabolism of lipids in the liver. <i>Taiwanofungus salmonea</i> and <i>Grifola frondosa</i>, which are valuable medicinal mushrooms in Taiwan and exhibit many beneficial bioactivities, are used to evaluate effects on immune regulation in Raw 264.7 cells and on NASH-related responses in Hep G2 cells. According to the results, the production of proinflammatory cytokines was effectively decreased, whereas the production of interleukin-10 was increased. Lipid accumulation and reactive oxygen species production also declined, and free glycerol was released. The expression of acetyl-CoA carboxylase, fatty acid synthase, and sterol regulatory element-binding protein 1c was decreased. These results indicate that <i>T. salmonea</i> and <i>G. frondosa</i> are capable of reducing inflammatory responses and ameliorating NASH, indicating their potential as hepatoprotective dietary supplements.
PB Begell House
LK https://www.dl.begellhouse.com/journals/708ae68d64b17c52,3bbc0caf11567d34,009987296e8eefdf.html