RT Journal Article ID 054c34d83f38ff0f A1 Knežević, Aleksandar A1 Stajić, Mirjana A1 Živković, Lada A1 Milovanović, Ivan A1 Spremo-Potparević, Biljana A1 Vukojević, Jelena T1 Antifungal, Antioxidative, and Genoprotective Properties of Extracts from the Blushing Bracket Mushroom, Daedaleopsis confragosa (Agaricomycetes) JF International Journal of Medicinal Mushrooms JO IJM YR 2017 FD 2017-09-12 VO 19 IS 6 SP 509 OP 520 K1 antifungal activity K1 antioxidative activity K1 Daedaleopsis confragosa K1 genoprotective activity K1 medicinal mushrooms AB This study aimed to evaluate the antifungal, antioxidative, and genoprotective potentials of various extracts of Daedaleopsis confragosa fruiting bodies and mycelia. The extracts exhibited weak fungistatic and an absence of any fungicidal activities against 7 important animal and human pathogens. Although mycelial extracts, especially the hot water extract, were more effective antifungal agents than basidiocarp extracts, they were significantly weaker than the commercial antimycotic ketoconazole. The tested extracts reduced DPPH radicals to various extents, depending on the material used for extraction and the solvent. The mycelial hot water extract was the best DPPH radical scavenger (half-maximal effective concentration, 3.42 mg mL-1), whereas the 96` ethanol extract of basidiocarps was the weakest one (half-maximal effective concentration, 5.36 mg mL-1). Phenols were the main carriers of activity, and their proportions in the tested extract mainly depended on the type and concentration of the solvent; the effect of the material used for extraction was negligible. The largest amount of phenols was detected in the 70% ethanol extract of basidiocarps (126.40 μg gallic acid equivalents mg-1) and the lowest in the basidiocarp methanol extract (19.93 μg gallic acid equivalents mg-1). Aqueous extracts of basidiocarp and mycelial extracts were not genotoxic agents but exhibited significant protective activity against hydrogen peroxide–induced DNA damage during use in leukocytes' pre- and post-treatments. PB Begell House LK https://www.dl.begellhouse.com/journals/708ae68d64b17c52,6f23ed8c50dfbce0,054c34d83f38ff0f.html