%0 Journal Article %A Sajjadi, Amir Yousef %A Mitra, Kunal %A Guo, Zhixiong %D 2013 %I Begell House %K thermal ablation, heat shock proteins, tumor removal, shor-pulse laser, laser-tissue interaction, plasma mediated ablation, HSP70, HSP47, ablation modeling %N 3-4 %P 345-388 %R 10.1615/HeatTransRes.2012006425 %T THERMAL ANALYSIS AND EXPERIMENTS OF LASER−TISSUE INTERACTIONS: A REVIEW %U https://www.dl.begellhouse.com/journals/46784ef93dddff27,614148a2796729f7,05ae7d4d58b312ea.html %V 44 %X Studying the interaction of ultrashort pulse lasers with biological tissues and the corresponding mathematical modeling of possible thermal damage is of fundamental importance to the understanding of laser-tissue interaction for advancing surgical application of lasers. The objective of this paper is to review the existing techniques for thermal analysis of laser-tissue interaction, focusing on temperature rise and plasma-mediated ablation. Different laser-tissue interaction mechanisms are discussed, and the existing techniques for characterization of extent of damage are presented. A novel approach of using a focused laser beam from an ultrashort pulse laser source to ablate the subcutaneous tumors with minimal thermal effects is introduced. The extent of laser-induced damage is studied by determining the space-time expression patterns of heat shock proteins. %8 2013-04-19