RT Journal Article
ID 0bc879a70de5e27e
A1 Pohleven, Jure
A1 Kos, Janko
A1 Sabotic, Jerica
T1 Medicinal Properties of the Genus Clitocybe and of Lectins from the Clouded Funnel Cap Mushroom, C. nebularis (Agaricomycetes): A Review
JF International Journal of Medicinal Mushrooms
JO IJM
YR 2016
FD 2016-12-20
VO 18
IS 11
SP 965
OP 975
K1 antimicrobial
K1 antitumor
K1 Clitocybe
K1 Clitocybe nebularis
K1 immunomodulatory
K1 lectin
K1 medicinal mushrooms
AB Current knowledge of the medicinal properties of Basidiomycetes mushroom species of the genus Clitocybe and of the biological activity of C. nebularis fruiting bodies is reviewed. The main focus is the therapeutic potential of lectins from C. nebularis. Species of the genus Clitocybe, including C. nebularis, have not been traditionally considered as medicinal mushrooms; however, recent studies have demonstrated their antitumor, immunomodulatory, and antioxidative properties, their antimicrobial (antiviral, antibacterial, and antifungal) activities against various bacteria and fungi, as well as their potential use in therapy for alcoholism and as psychotropic agents. These activities have been shown to be due to various compounds, either isolated or in extracts, mainly polysaccharides but also phenols, ribonucleosides, and proteins. These include laccase, protease inhibitors, and lectins. C. nebularis has been shown to be rich in a variety of lectins and isolectins with distinct carbohydrate-binding specificities, showing versatile biological activities. They exhibit immunostimulatory and adhesion-/phagocytosis-promoting properties, as well as toxicity in various invertebrates. Mushroom species of the genus Clitocybe, including C. nebularis, thus constitute a valuable source of compounds showing diverse biological activities with a broad potential for applications in biomedicine or biotechnology. On the basis of such evidence reviewed here, we propose that C. nebularis and other Clitocybe species can be considered to be medicinal mushrooms.
PB Begell House
LK https://www.dl.begellhouse.com/journals/708ae68d64b17c52,07a0495239bddf76,0bc879a70de5e27e.html