%0 Journal Article %A Voznesenska, Tetyana Yu. %A Bryzgina, Tetyana M. %A Sukhina, Vera S. %A Makogon, Nataliya V. %A Alexeyeva, Irina N. %D 2011 %I Begell House %K ovarium, immune ovary failure, meiotic maturation of oocytes, follicular cells, apoptosis, necrosis, curcumin %N 2 %P 133-140 %R 10.1615/IntJPhysPathophys.v2.i2.40 %T Influence of the Inhibitor of Nf-KB Activation, Curcumin, on the Oogenesis and Follicular Cell Death under Immune Ovarian Failure in Mice %U https://www.dl.begellhouse.com/journals/6ec4ba27650016b1,71a1a30208e0afa6,145f0fb70952b926.html %V 2 %X In experiments on CBA mice, we studied an influence of an inhibitor of nuclear transcription factor kB activation curcumin, obtained from Curcuma longa, on the meiotic maturation of oocytes and apoptotic and necrotic death of follicular cells at immune ovary failure induced by immunization of animals with allogenic ovarian extracts. NF-kB plays a pivotal role in the induction of genes encoding pro- inflammatory factors (cytokines, adhesion molecules, inducible NO- synthase and cyclooxygenase) and in regulation of cell proliferation and death. It has been shown that immunization of mice increased the death of follicular cells through a apoptotic and necrotic pathways, which led to inflammatory response (according to leukogramom of the oocytes at metaphase I and II). Intragastric administration of curcumin (Sigma, USA, 2mg of the mouse weight, four times a week during the period of immunization) reduced the number of the follicular cells, died through apoptotic and especially necrotic path-way. It attempted inflammatory response and improved the meiotic maturation of oocytes im-paired under experimental immune ovarian failure in mice. %8 2011-06-06