RT Journal Article
ID 15c3fbd86932e37f
A1 Ryall , Nicola H. 
A1 Helliwell, P.
T1 A Critical Review of Ankylosing Spondylitis
JF Critical Reviews™ in Physical and Rehabilitation Medicine
JO CRP
YR 1998
FD 1998-09-15
VO 10
IS 3
SP 265
OP 301
K1 spondyloarthropathy
K1 physical treatments
K1 biomechanics
K1 radiology.
AB Ankylosing spondylitis is a progressive, inflammatory, axial, and peripheral arthropathy of unknown etiology. Ankylosing spondylitis is a chronic debilitating disease. It affects the axial spine with pain, loss of mobility, osteoporosis, and increased fracture rate. It may also cause peripheral arthritis, as well as having many extraarticular multisystemic manifestations. The underlying lesion is believed to be enthesitis. Risk factors include being young, male, and a positive HLA-B27 antigen. The role of gut pathogens is less clear. In recent years major advances have occurred in pathogenesis, yet we still do not know the precise natural history or the optimal treatment strategy. A multidisciplinary approach to treatment is recommended, centered around patient knowledge and education as well as exercise and physiotherapy. Simple analgesics and antiinflammatory drugs also play important roles. As outcome is variable, ankylosing spondylitis needs long-term monitoring and management. This has important economic implications.
PB Begell House
LK https://www.dl.begellhouse.com/journals/757fcb0219d89390,116fde0c2fbb75e4,15c3fbd86932e37f.html