RT Journal Article ID 20b23c9b5b0dcf47 A1 Sharma, Priyanka A1 Parmar, Jyoti A1 Verma, Preeti A1 Goyal, Pradeep Kumar T1 Modulatory influence of Phyllanthus niruri on oxidative stress, antioxidant defense and chemically induced skin tumors JF Journal of Environmental Pathology, Toxicology and Oncology JO JEP(T) YR 2011 FD 2011-06-01 VO 30 IS 1 SP 43 OP 53 K1 Carcinogenesis K1 Phyllanthus niruri K1 Chemoprevention K1 Reactive oxygen species (ROS) K1 Tumor incidence K1 Superoxide dismutase K1 Catalase K1 Glutathione AB The present study evaluates the modulatory potential of Phyllanthus niruri on chemically induced skin carcinogenesis and its influence on oxidative stress and the antioxidant defense system. Oral administration of P. niruri extract (PNE), during peri- (Gr. III), post- (Gr. IV) or peri- and post- (Gr. V) initiational stages of 7,12-dimethylbenz(a)anthracene (DMBA) / croton oil induced papillomagenesis considerably reduced tumor burden to 4.20, 4.00 and 3.33 (positive control value 6.20); cumulative number of papillomas to 21, 16 and 10 respectively (positive control value 62); and incidence of mice bearing papillomas to 50%, 40%, and 30%, respectively (positive control value 100%) but significantly increased the average latent period to 10.14, 10.62 and 11.60 and inhibition of tumor multiplicity to 66%, 74% and 83%respectively. Enzyme analysis of skin and liver showed a significant (p ≤ 0.05, ≤ 0.01, ≤ 0.001) elevation in antioxidant parameters such as superoxide dismutase, catalase, glutathione and vitamin C in PNE treated groups (Gr. III-V) when compared with the carcinogen treated control (Gr. II). The elevated level of lipid peroxidation in the carcinogen treated positive control group was significantly (p ≤ 0.05, ≤ 0.01, ≤ 0.001) inhibited by PNE administration. These results indicate that Phyllanthus niruri extract has potentiality to reduce skin papillomas by enhancing antioxidant defense system. PB Begell House LK https://www.dl.begellhouse.com/journals/0ff459a57a4c08d0,391ee7667f98e533,20b23c9b5b0dcf47.html