RT Journal Article
ID 35856ff546e47ff9
A1 Noreen, Nida
A1 Muhammad, Faqir
A1 Akhtar, Bushra
A1 Azam, Farooq
A1 Anwar, Muhammad Irfan
T1 Is Cannabidiol a Promising Substance for New Drug Development? A Review of its Potential Therapeutic Applications
JF Critical Reviews™ in Eukaryotic Gene Expression
JO CRE
YR 2018
FD 2018-04-10
VO 28
IS 1
SP 73
OP 86
K1 diclofenac sodium
K1 cancer
K1 Cannabis sativa
K1 IFNa
K1 ID-1
AB The pharmacological importance of cannabidiol (CBD) has been in study for several years. CBD is the major nonpsychoactive constituent of plant Cannabis sativa and its administration is associated with reduced side effects. Currently, CBD is undergoing a lot of research which suggests that it has no addictive effects, good safety profile and has exhibited powerful therapeutic potential in several vital areas. It has wide spectrum of action because it acts through endocannabinoid receptors; CB1 and CB2 and it also acts on other receptors, such as GPR18, GPR55, GPR 119, 5HT1A, and TRPV2. This indicates its therapeutic value for numerous medical conditions because of its neuroprotective and immunomodulatory properties. Potential therapeutic applications of CBD include, analgesic, anti-inflammatory, anxiolytic, anti-arthritic, anti-depressant, anti-Alzheimer disease, anti-ischemic, neuroprotective, and anti-fibrotic. More promising areas appear to include diabetes and cancer where CBD exhibits lesser side effects and more therapeutic benefits as compared to recent available medical therapies. Hence, CBD is a promising substance for the development of new drug. However further research and clinical studies are required to explore its complete potential.
PB Begell House
LK https://www.dl.begellhouse.com/journals/6dbf508d3b17c437,642ad759707fc517,35856ff546e47ff9.html