RT Journal Article
ID 38c99a200070399c
A1 Lai, Chun-Hong
A1 Teng, Ju-Fang
A1 Hsu, Tai-Hao
A1 Lin, Fang-Yi
A1 Yang, Po-Wen
A1 Lo, Hui-Chen
T1 28-Day Oral Safety Evaluation of Extracellular Polysaccharopeptides Produced in Submerged Culture from the Turkey Tail Medicinal Mushroom Trametes versicolor (L.:Fr.) Pilát LH-1 in Mice
JF International Journal of Medicinal Mushrooms
JO IJM
YR 2011
FD 2011-06-22
VO 13
IS 3
SP 227
OP 236
K1 medicinal mushrooms
K1 Trametes versicolor
K1 extracellular polysaccharopepdes
K1 safety evaluation
K1 submerged culture
AB Turkey tail medicinal mushroom, Trametes versicolor (TV), is a species with a variety of pharmacological activities. Its intracellular polysaccharopeptides are widely commercialized. Recently, we found a novel TV strain LH-1 in Taiwan and demonstrated that the extracellular polysaccharopeptide (ePSP) of LH-1 obtained from submerged culture exhibits significant immunomodulatory activity. In this in vivo study, we further evaluated the safety of orally administered LH-1 ePSP using both male and female ICR mice. The LH-1 ePSP was orally administered to mice at levels of 0 (water), 100 (low dose), 500 (medium dose), or 1000 mg/kg/day (high dose) for 28 days. Clinical observations, growth, food consumption, histopathological examination, and clinical biochemical analyses revealed no adverse effects of LH-1 ePSP in mice. There were no significant differences in the results of target organ weights, hematological analyses, and urinalysis examination among groups. However, male mice that ingested high doses of LH-1 ePSP tended to have decreased lung weights and platelet numbers. In conclusion, the results of the present study suggested that oral administration of LH-1 ePSP for 28 days is accompanied by no obvious signs of toxicity. The lack of toxicity supports the potential use of LH-1 ePSP as a food or dietary supplement.
PB Begell House
LK https://www.dl.begellhouse.com/journals/708ae68d64b17c52,44cae58e6753b88e,38c99a200070399c.html