RT Journal Article
ID 4018ff873eec8115
A1 Reznikov, Alexander G. 
A1 Chaikovskaya, L. V.
A1 Polyakova, L. I.
A1 Sachynska, Olga V. 
T1 Effects of Cytokine-Like Polypeptide EMAP II and Flutamide on Testosterone-Stimulated Prostate of Castrated Rats
JF International Journal of Physiology and Pathophysiology
JO IJPP
YR 2012
FD 2012-06-09
VO 3
IS 2
SP 175
OP 184
K1 EMAP II
K1 flutamide
K1 apoptosis
K1 proliferation
K1 rat prostate
K1 castration
K1 testosterone propionate
AB The effects of separate and combined administration of cytokine-like polypeptide EMAP II and flutamide, a non-steroid antiandrogen, on morphologyy and function of the accessory sexual glands in castrated immature male rats stimulated with testosterone propionate were studied. Anti-androgenic, pro-apoptotic, and pro-coagulating effects of EMAP II have been revealed in the ventral prostate. Combined use of the drugs resulted in enhanced anti-prostatic effects capable of inhibiting the processes of proliferation and apoptosis, as well as DNA, RNA and protein contents. Combined use of EMAP II and flutamide may be useful in developing new therapeutic modalities in prostate cancer.
PB Begell House
LK https://www.dl.begellhouse.com/journals/6ec4ba27650016b1,551b155962667b02,4018ff873eec8115.html