RT Journal Article
ID 416237ad7507fb9a
A1 Zhao, Ruocong
A1 Lai, Yunxin 
A1 Li, Peng
T1 Kruppel-Like Factor 4: From Physiological Functions to Tumor Therapy
JF Onco Therapeutics
JO OT
YR 2016
FD 2017-01-20
VO 7
IS 1-2
SP 153
OP 158
K1 KLF4
K1 leukemia
K1 solid tumor
AB Kruppel-like factor 4 (KLF4) is a zinc finger transcription factor that can regulate diverse cellular physiological functions such as cell growth, death, differentiation, and migration. Recent studies have suggested that KLF4 can act as either a suppressor or oncogene for different types of cancers, ranging from solid tumors to leukemia, by regulating target genes involved in tumor cell proliferation, survival, metastasis, invasiveness, and the constitution of the tumor microenvironment. In most cancer types, KLF4 has shown the ability to inhibit tumor progression, thus raising the possibility that it may be a novel target for multiple types of cancer, including T-cell acute lymphoblastic leukemia, which lacks targeted drugs in clinical practice. A better understanding of the role of KLF4 in tumorigenesis will facilitate the application of this potential molecular target for tumor therapy.
PB Begell House
LK https://www.dl.begellhouse.com/journals/2c6306423483e001,2451af3842dace87,416237ad7507fb9a.html