RT Journal Article ID 5811746c1e4a10b8 A1 Donnini, Sandra A1 Finetti, Federica A1 Terzuoli, Erika A1 Bazzani, Lorenzo A1 Ziche, Marina T1 Targeting PGE2 Signaling in Tumor Progression and Angiogenesis JF Onco Therapeutics JO OT YR 2014 FD 2015-07-31 VO 5 IS 3-4 SP 223 OP 232 K1 Angiogenesis K1 inflammation K1 mPGES-1 K1 PGE2 K1 RTK AB Inflammatory milieu is associated with cancer progression and angiogenesis in different types of tumors, such as gastrointestinal, breast, prostate, and head and neck cancers. Among the inflammatory pathways, numerous evidence indicates that the cyclooxygenase-2/microsomal prostaglandin E synthase-1/prostaglandin E2/E Prostaglandin type receptor (COX-2/mPGES-1/PGE2/EPs) signaling supports epithelial tumor aggressiveness promoting cell growth, epithelial-mesenchymal transition (EMT), and sternness. Further, PGE2 modulates pro-oncogenic and pro-angiogenic pathways such as EGFR and FGFR-1. In this review, we discuss the role of PGE2 and its network of partner proteins in tumor progression and angiogenesis. We also discuss major COX-2/mPGES-1 and EPs therapeutic advances that have been made over the past few years in targeting tumorigenesis and angiogenesis. PB Begell House LK https://www.dl.begellhouse.com/journals/2c6306423483e001,5749d30276266f6f,5811746c1e4a10b8.html