RT Journal Article
ID 6aa3ad337f54ac4d
A1 Rusten, Tor Erik
A1 Haglund, Kaisa
A1 Stenmark, Harald
T1 Aberrant Receptor Signaling and Trafficking as Mechanisms in Oncogenesis
JF Critical Reviews™ in Oncogenesis
JO CRO
YR 2007
FD 2007-09-07
VO 13
IS 1
SP 39
OP 74
AB Intracellular signaling pathways activated through cell surface receptors are essential for cell proliferation, differentiation, survival, and migration. Dysregulation of such signaling through mutations, chromosome rearrangements, aberrant gene expression, or epigenetic changes is a key factor in oncogenesis. Prominent examples of receptor signaling pathways that are dysregulated in cancers include those initiated by receptor tyrosine kinases, WNT, TGFβ, and Notch receptors. In this review we will discuss these signaling pathways and how their dysfunction may contribute to oncogenesis. We will also highlight the important role of endocytic membrane trafficking in receptor signaling and tumor suppression.
PB Begell House
LK https://www.dl.begellhouse.com/journals/439f422d0783386a,03e4ce9b19ac1381,6aa3ad337f54ac4d.html