Library Subscription: Guest
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections
Journal of Environmental Pathology, Toxicology and Oncology
IF: 1.241 5-Year IF: 1.349 SJR: 0.519 SNIP: 0.613 CiteScore™: 1.61

ISSN Print: 0731-8898
ISSN Online: 2162-6537

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvironPatholToxicolOncol.2014011320
pages 205-218

Curative Effect of Amorphophallus campanulatus (Roxb.) Blume. Tuber On N-Nitrosodiethylamine- Induced Hepatocellular Carcinoma in Rats

Puthuparampil Nazarudeen Ansil
Biochemistry and Pharmacognosy Research Laboratory, School of Biosciences, Mahatma Gandhi University, P.D. Hills. P.O, Kottayam, Kerala, India
Anand Nitha
Biochemistry and Pharmacognosy Research Laboratory, School of Biosciences, Mahatma Gandhi University, P.D. Hills. P.O, Kottayam, Kerala, India
Santhibhavan Prabhakaran Prabha
Biochemistry and Pharmacognosy Research Laboratory, School of Biosciences, Mahatma Gandhi University, P.D. Hills. P.O, Kottayam, Kerala, India
Mukalel Sankunni Latha
Biochemistry and Pharmacognosy Research Laboratory, School of Biosciences, Mahatma Gandhi University, P.D. Hills. P.O, Kottayam, Kerala, India

ABSTRACT

In this study, we investigated the curative effect of Amorphophallus campanulatus tuber methanolic extract (ACME) on N-nitrosodiethylamine (NDEA)−induced hepatocellular carcinoma (HCC) in experimental rats. All of the rats except those in the normal control group received 0.02% NDEA orally (2 mL, 5 days/week) for the first 20 weeks of the experiment. In different treatment groups, after 20 weeks of NDEA challenge, rats were supplemented with ACME (125 and 250 mg/kg body weight, orally) for the following 28 days. In addition, a standard drug control group was supplemented with silymarin (100 mg/kg bw, orally), a known tumorsuppressive agent against HCC. Administration of ACME significantly inhibited the NDEA-induced increase of hepatic nodule incidence, nodule multiplicity, and serum biochemical indices, and improved the hepatocellular architecture in a dose-dependent manner. The biochemical analysis of hepatic tissues further demonstrated that ACME counteracts NDEA-induced oxidative stress through the restoration of antioxidant enzymes. NDEAadministered rats also showed amplified expression of proliferating cell nuclear antigen in the liver, and decreased expression of this proliferative marker was clearly observed upon the supplementation of ACME. Notably, 250 mg/kg bw ACME supplementation showed better results than the other treatment regimens; this result might be associated with the enhancement of antioxidant activity and inhibition of hepatic cell proliferation.


Articles with similar content:

Study of the Protective Effects of Katha (Heartwood Extract of Acacia catechu) in Liver Damage Induced by Iron Overload
Journal of Environmental Pathology, Toxicology and Oncology, Vol.32, 2013, issue 3
Nikhil Baban Ghate, Dipankar Chaudhuri, Nripendranath Mandal, Rhitajit Sarkar, Bibhabasu Hazra
D-Pinitol Protects Against Carbon Tetrachloride−Induced Hepatotoxicity in Rats
Journal of Environmental Pathology, Toxicology and Oncology, Vol.34, 2015, issue 4
Peramaiyan Rajendran, Maruthaiveeran Periyasamy Balasubramanian, Natarajan Nandakumar , Boobathy Lokeshkumar, Thamaraiselvan Rengarajan
Rutin Protects against Doxorubicin-Induced Cognitive Dysfunction While Retaining the Anticancer Potential of Dox in a Murine Model of N-Methyl-N-Nitrosourea – Induced Mammary Carcinoma
Journal of Environmental Pathology, Toxicology and Oncology, Vol.38, 2019, issue 2
Anoop Kishore, Sulaiman M. Alnaseer, Krishnadas Nandakumar, Grandhi Venkata Ramalingayya, Pawan G. Nayak, Shalam M. Hussain, Chamallamudi Mallikarjuna Rao, Karthik Gourishetti
Chemopreventive Action of Diclofenac in Dimethybenzanthracene Induced Lung Cancer in Female Wistar Rat
Journal of Environmental Pathology, Toxicology and Oncology, Vol.29, 2010, issue 3
Sankar Nath Sanyal, Poonam Thakur
Colono-protective Potentiality of Methanolic Bark Extract of Acacia catechu: A Medicinal Plant against 1,2-Dimethylhydrazine–Induced Toxicity in Wistar Rats
Journal of Environmental Pathology, Toxicology and Oncology, Vol.37, 2018, issue 4
Abul Vafa, Rahat Ali, Sarwat Sultana, Aisha Siddiqi, Alpashree, Preeti Barnwal, Syed Kazim Hasan, Shekh Mohammad Afzal, Johirul Islam