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Journal of Environmental Pathology, Toxicology and Oncology
IF: 1.241 5-Year IF: 1.349 SJR: 0.519 SNIP: 0.613 CiteScore™: 1.61

ISSN Print: 0731-8898
ISSN Online: 2162-6537

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvironPatholToxicolOncol.v20.i2.60
8 pages

Sister Chromatid Exchanges and Micronuclei in Lymphocytes of Operating Room Personnel Occupationally Exposed to Enfluorane and Nitrous Oxide

Rossana Pasquini
Department of Hygiene, University of Perugia, Perugia, Italy
Giuseppina Scassellati-Sforzolini
Department of Hygiene, University of Perugia, Perugia, Italy
Cristina Fatigoni
Department of Hygiene, University of Perugia, Perugia, Italy
Massimiliano Marcarelli
Department of Hygiene, University of Perugia, Perugia, Italy
Silvano Monarca
Department of Experimental and Applied Medicine, Section of Hygiene, University of Brescia, Brescia, Italy
Francesco Donato
Department of Experimental and Applied Medicine, Section of Hygiene, University of Brescia, Brescia, Italy
Stefano Cencetti
Azienda Ospedaliera, Perugia, Italy
Francesco Maria Cerami
Azienda Ospedaliera, Perugia, Italy

ABSTRACT

The objective of this article is to assess whether occupational exposure to anesthetics increases genotoxic risk.We investigated two cytogenetic biomarkers, sister chromatid exchanges (SCE) and micronuclei (MN), in the peripheral blood lymphocytes of 46 anesthesiologists (24 men), working in operating rooms and mostly exposed to enfluorane and nitrous oxide, and 66 controls (35 men), not exposed to chemicals and living in the same area. Contrary to what was expected, a lower frequency of SCE was found in male anesthesiologists than in controls. Smoking status was found to be positively associated with SCE frequency in each group, while no relation to age was evident. On the contrary, MN frequency was significantly higher in female, but not male, anesthesiologists than in controls. Age and smoking status did not modify the association.No relationship between MN frequency and duration of employment was found in anesthesiologists. Smoking status and mean number of cigarettes smoked per day in smokers were not associated with MN frequency in either anesthesiologists or in controls. MN analysis seems to be a sensitive index of possible genotoxic effects of occupational exposure to anesthesiologists, and women appear to be more susceptible to these effects than men.


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