Library Subscription: Guest
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections
Journal of Environmental Pathology, Toxicology and Oncology
IF: 1.241 5-Year IF: 1.349 SJR: 0.519 SNIP: 0.613 CiteScore™: 1.61

ISSN Print: 0731-8898
ISSN Online: 2162-6537

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvironPatholToxicolOncol.v20.iSuppl.1.110
14 pages

Reactivity of Free Radicals on Hydroxylated Quartz Surface and Its Implications for Pathogenicity of Silicas: Experimental and Quantum Mechanical Study

Robert Konecny
National Institute for Occupational Safety and Health, Morgantown,WV. *Current address: Keck Center, University of California San Diego,La Jolla
Steve Leonard
National Institute for Occupational Safety and Health, Morgantown,WV. *Current address: Keck Center, University of California San Diego,La Jolla
Xianglin Shi
Division of Nutritional Sciences, Pharmacology and Nutritional Sciences, College of Medicine, University of Kentucky, Lexington, KY; Center for Research on Environmental Disease, College of Medicine, University of Kentucky, Lexington, KY; Toxicology and Cancer Biology, College of Medicine, University of Kentucky, Lexington, KY
Victor A. Robinson
National Institute for Occupational Safety and Health: Health Effects Laboratory Division, Morgantown,WV
Vincent Castranova
Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505

ABSTRACT

We studied the adsorption of hydroxyl radicals and superoxide anion radicals on a hydroxylated a-quartz surface using cluster and periodic slab models by means of density functional calculations. Models of two hydroxylated a-quartz surfaces—(0001) and (01111)—have been used in the simulations. The hydroxyl radical adsorbs readily on both surfaces. The subsurface Si–O bonds are weakened during the adsorption resulting in surface layer destabilization. This destabilization leads directly to surface disintegration in the case of •OH/(01111) adsorption. The product of the surface disintegration and reconstruction is a surface terminated by silanol groups (Si–OH) and siloxyl radicals (Si–O•). The model calculations suggest that adsorption of •OH on a hydroxylated quartz surface transforms a chemically inert, aged, silanol terminated surface to a very reactive, silicon-based radical terminated surface. The activated surface may then cause oxidative damage to the adsorbed biomaterial. The superoxide anion radical adsorbs on both surfaces, but the adsorption products are only weakly bonded to the surface. The calculated energy barrier for the O2•– activated subsurface Si–O bond dissociation is 10 kcal/mol, which is higher than for the •OH activated process (4 kcal/mol). The calculated weaker bonding to the surface and higher activation energy barrier suggest that the superoxide anion radical will be less efficient in reactivation of an aged, hydroxylated quartz surface than the hydroxyl radical. The importance of the specific geometry of the surface silicon atoms on the surface reactivity and adsorption properties is also discussed. The theoretical predictions are supported experimentally using chemiluminescence to monitor reactivation of the aged silica surface by superoxide anion radicals.


Articles with similar content:

Macrophage Polarization and Activation in Response to Implant Debris: Influence by "Particle Disease" and "Ion Disease"
Journal of Long-Term Effects of Medical Implants, Vol.24, 2014, issue 4
Jiri Gallo, Stuart B. Goodman, Yuya Takakubo, Michiaki Takagi, Christophe Nich, Jukka Pajarinen, Yrjo T. Konttinen
Study of excited atomic states of hydrogen and chemical phenomena on liquid silicon target under a RF inductive thermal plasma torch
High Temperature Material Processes: An International Quarterly of High-Technology Plasma Processes, Vol.5, 2001, issue 2
Jacques Amouroux, F. Bourg, F. Krayem, Daniel Morvan
RADIATION EFFECTS WITH THE TRANSIENT LINE SOURCE MEASUREMENT OF FLUID THERMAL CONDUCTIVITY
International Heat Transfer Conference 6, Vol.3, 1978, issue
James E. S. Venart, Akio Saito
CONJUGATE HEAT TRANSFER BETWEEN FREE CONVECTION IN POROUS MEDIUM AND FORCED CONVECTION
Journal of Porous Media, Vol.15, 2012, issue 5
mohamed mosaad
Silica and PM1648 Modify Human Alveolar Macrophage Antigen-Presenting Cell Activity In Vitro
Journal of Environmental Pathology, Toxicology and Oncology, Vol.20, 2001, issue Suppl.1
Raymond F. Hamilton, Andrij Holian, Gailen D. Marshall