Library Subscription: Guest
Critical Reviews™ in Immunology

Published 6 issues per year

ISSN Print: 1040-8401

ISSN Online: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

Indexed in

Gain Access(open in a new tab)
More
Purchase $35.00(open in a new tab) Check subscription Download MARC record(open in a new tab) Get Permissions(open in a new tab)

Naturally Occurring Regulatory T Cells: Recent Insights in Health and Disease

Volume 27, Issue 1, 2007, pp. 61-95
DOI: 10.1615/CritRevImmunol.v27.i1.50
Get accessGet access
Giorgio Raimondi
Thomas E. Starzl Transplantation Institute and Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Michael S. Turner
Departments of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Angus W. Thomson
Thomas E. Starzl Transplantation Institute and Departments of Surgery and Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA; Co-senior authors
Penelope A. Morel
Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA; Co-senior authors

ABSTRACT

Development of naturally occurring CD4+CD25+ T regulatory cells (Treg) in the thymus requires the transcription factor Foxp3. Major histocompatibility complex (MHC) class II, self-ligands expressed by epithelial cells, and thymic stromal lymphopoietin also appear to play important roles. In addition, several molecular regulators of T-cell receptor (TCR) signaling (both positive and negative) have been implicated in the control of Treg development. Foxp3 is a transcriptional repressor of IL-2 and other cytokines and appears to maintain the anergic and suppressor function of these cells. Multiple cell types (T cells, B cells, dendritic cells [DC], and natural killer [NK] cells) are targeted by Treg using diverse suppressor mechanisms, whereas factors that regulate Treg proliferation and function, including Toll-like receptor (TLR) ligands, have also been identified. Because Treg play an important role in the control of autoimmunity, therapeutic strategies are being pursued to enhance their numbers and function in specific autoimmune diseases. In transplantation, where Treg also offer potential for therapy of rejection and graft-versus-host disease (GVHD), indirect allorecognition may be the dominant pathway for immune regulation by these cells. In tumor immunology, Treg have emerged as major suppressors of T-cell-mediated antitumor responses and represent a significant obstacle to effective anticancer vaccines. Strategies aimed at depletion/functional inhibition of these cells by molecular targeting must maintain a critical balance between tumor immunity and self-tolerance.

CITED BY

  1. Montero Vega M.T., Montero Vega M.T., A new era for innate immunity, Allergologia et Immunopathologia, 36, 3, 2008. Crossref

  2. Samochocki Zbigniew, Alifier Marek, Bodera Paweł, Jeziorkowska Renata, Rosiak Ewa, Jurkiewicz Beata, Glińska Olga, Gliński Wiesław, Stankiewicz Wanda, T-regulatory cells in severe atopic dermatitis: alterations related to cytokines and other lymphocyte subpopulations, Archives of Dermatological Research, 304, 10, 2012. Crossref

  3. Lee Hyojung, Kim Hyunseong, Lee Gihyun, Chung Hwan-Suck, Bae Hyunsu, Curcumin attenuates lupus nephritis upon interaction with regulatory T cells in New Zealand Black/White mice, British Journal of Nutrition, 110, 1, 2013. Crossref

  4. Hamza Eman, Steinbach Falko, Marti Eliane, CD4+CD25+ T cells expressing FoxP3 in Icelandic horses affected with insect bite hypersensitivity, Veterinary Immunology and Immunopathology, 148, 1-2, 2012. Crossref

  5. Sahu Ravi P., Turner Matthew J., DaSilva Sonia C., Rashid Badri M., Ocana Jesus A., Perkins Susan M., Konger Raymond L., Touloukian Christopher E., Kaplan Mark H., Travers Jeffrey B., The environmental stressor ultraviolet B radiation inhibits murine antitumor immunity through its ability to generate platelet-activating factor agonists, Carcinogenesis, 33, 7, 2012. Crossref

  6. Montero Vega M.T., de Andrés Martín A., Toll-like receptors: a family of innate sensors of danger that alert and drive immunity, Allergologia et Immunopathologia, 36, 6, 2008. Crossref

  7. Selvaraj Ramesh K., Avian CD4+CD25+ regulatory T cells: Properties and therapeutic applications, Developmental & Comparative Immunology, 41, 3, 2013. Crossref

  8. Sakakura Koichi, Chikamatsu Kazuaki, Immune suppression and evasion in patients with head and neck cancer, Advances in Cellular and Molecular Otolaryngology, 1, 1, 2013. Crossref

  9. Meier Jeremy, Roberts Catherine, Avent Kassi, Hazlett Allison, Berrie Jennifer, Payne Kyle, Hamm David, Desmarais Cindy, Sanders Catherine, Hogan Kevin T., Archer Kellie J., Manjili Masoud H., Toor Amir A., Fractal Organization of the Human T Cell Repertoire in Health and after Stem Cell Transplantation, Biology of Blood and Marrow Transplantation, 19, 3, 2013. Crossref

  10. Lakshmi Narendra Bodduluru, Eshvendar Reddy Kasala, Shantikumar Saladi, Ramakrishna Sistla, Immune system: a double-edged sword in cancer, Inflammation Research, 62, 9, 2013. Crossref

  11. Dons Eefje M., Raimondi Giorgio, Cooper David K. C., Thomson Angus W., Non-Human Primate Regulatory T Cells: Current Biology and Implications for Transplantation, Transplantation, 90, 8, 2010. Crossref

  12. Yarkoni Shai, Kaminitz Ayelet, Sagiv Yuval, Yaniv Isaac, Askenasy Nadir, Involvement of IL-2 in homeostasis of regulatory T cells: the IL-2 cycle, BioEssays, 30, 9, 2008. Crossref

  13. Pan Deshun, Shin Young-Ha, Gopalakrishnan Geetha, Hennessey James, De Groot Leslie J., Regulatory T cells in Graves’ disease, Clinical Endocrinology, 71, 4, 2009. Crossref

  14. Kim Hyunseong, Lee Gihyun, Park Soojin, Chung Hwan-Suck, Lee Hyojung, Kim Jong-Yoon, Nam Sangsoo, Kim Sun Kwang, Bae Hyunsu, Bee Venom Mitigates Cisplatin-Induced Nephrotoxicity by Regulating CD4+CD25+Foxp3+Regulatory T Cells in Mice, Evidence-Based Complementary and Alternative Medicine, 2013, 2013. Crossref

  15. Cattaruzza Lara, Gloghini Annunziata, Olivo Karin, Di Francia Raffaele, Lorenzon Debora, De Filippi Rosaria, Carbone Antonino, Colombatti Alfonso, Pinto Antonio, Aldinucci Donatella, Functional coexpression of Interleukin (IL)-7 and its receptor (IL-7R) on Hodgkin and Reed-Sternberg cells: Involvement of IL-7 in tumor cell growth and microenvironmental interactions of Hodgkin's lymphoma, International Journal of Cancer, 125, 5, 2009. Crossref

  16. Lee Hyojung, Nho Dukhee, Chung Hwan-Suck, Lee Heekyung, Shin Min-Kyu, Kim Sung-Hoon, Bae Hyunsu, CD4+CD25+ regulatory T cells attenuate cisplatin-induced nephrotoxicity in mice, Kidney International, 78, 11, 2010. Crossref

  17. Poliani Pietro Luigi, Vermi William, Facchetti Fabio, Thymus microenvironment in human primary immunodeficiency diseases, Current Opinion in Allergy & Clinical Immunology, 9, 6, 2009. Crossref

  18. Du Wei, Erden Ozlem, Wilson Andrew, Sipple Jared M., Schick Jonathan, Mehta Parinda, Myers Kasiani C., Steinbrecher Kris A., Davies Stella M., Pang Qishen, Deletion of Fanca or Fancd2 dysregulates Treg in mice, Blood, 123, 12, 2014. Crossref

  19. Meriggioli Matthew N., Sheng Jian Rong, Li Liangcheng, Prabhakar Bellur S., Strategies for Treating Autoimmunity, Annals of the New York Academy of Sciences, 1132, 1, 2008. Crossref

  20. Yolcu Esma S, Ash Shifra, Kaminitz Ayelet, Sagiv Yuval, Askenasy Nadir, Yarkoni Shai, Apoptosis as a mechanism of T‐regulatory cell homeostasis and suppression, Immunology & Cell Biology, 86, 8, 2008. Crossref

  21. Jaffe Elaine S., Adult T-Cell Leukemia/Lymphoma, in Hematopathology, 2011. Crossref

  22. Hwang Inkyu, Nguyen Nguyet, Mechanisms of tumor-induced T cell immune suppression and therapeutics to counter those effects, Archives of Pharmacal Research, 38, 8, 2015. Crossref

  23. Sheu Bor-Ching, Chang Wen-Chun, Huang Su-Cheng, New Era of Regulatory T Cells in Tumor Immunity: Insights in Cancer Immunotherapy, Journal of the Formosan Medical Association, 109, 1, 2010. Crossref

  24. Ishihara Dan, Iyengar Puneeth, Meyer Jeffrey, Timmerman Robert, Choy Hak, Hannan Raquibul, The combination of radiation therapy and immunotherapy for genitourinary cancer treatment: rationale, current evidence, and prospects, Journal of Radiation Oncology, 4, 4, 2015. Crossref

  25. Virella Gabriel, Lopes-Virella Maria F., Atherogenesis and the humoral immune response to modified lipoproteins, Atherosclerosis, 200, 2, 2008. Crossref

  26. Fairweather DeLisa, Frisancho-Kiss Sylvia, Rose Noel R., Sex Differences in Autoimmune Disease from a Pathological Perspective, The American Journal of Pathology, 173, 3, 2008. Crossref

  27. Storek Jan, Immunological reconstitution after hematopoietic cell transplantation – its relation to the contents of the graft, Expert Opinion on Biological Therapy, 8, 5, 2008. Crossref

  28. Whiteside Theresa L., Disarming suppressor cells to improve immunotherapy, Cancer Immunology, Immunotherapy, 61, 2, 2012. Crossref

  29. Lopes-Virella Maria F., Virella Gabriel, Clinical significance of the humoral immune response to modified LDL, Clinical Immunology, 134, 1, 2010. Crossref

  30. Adorini Luciano, Penna Giuseppe, Dendritic cell tolerogenicity: a key mechanism in immunomodulation by vitamin D receptor agonists, Human Immunology, 70, 5, 2009. Crossref

  31. Whiteside Theresa L., What are regulatory T cells (Treg) regulating in cancer and why?, Seminars in Cancer Biology, 22, 4, 2012. Crossref

  32. Nikitczuk Kevin P., Schloss Rene S., Yarmush Martin L., Lattime Edmund C., PLGA-Polymer Encapsulating Tumor Antigen and CpG DNA Administered into the Tumor Microenvironment Elicits a Systemic Antigen-Specific IFN-γ Response and Enhances Survival, Journal of Cancer Therapy, 04, 01, 2013. Crossref

  33. Hamza Eman, Gerber Vinzenz, Steinbach Falko, Marti Eliane, Equine CD4+ CD25high T cells exhibit regulatory activity by close contact and cytokine-dependent mechanisms in vitro, Immunology, 134, 3, 2011. Crossref

  34. Hussain Muzammal, Tang Fei, Liu Jinsong, Zhang Jiancun, Javeed Aqeel, Dichotomous role of protein kinase A type I (PKAI) in the tumor microenvironment: A potential target for ‘two-in-one’ cancer chemoimmunotherapeutics, Cancer Letters, 369, 1, 2015. Crossref

  35. Eghtesad Saman, Morel Penelope A., Clemens Paula R., The companions: regulatory T cells and gene therapy, Immunology, 127, 1, 2009. Crossref

  36. Montero Vega M.T., de Andrés Martín A., The significance of toll-like receptors in human diseases, Allergologia et Immunopathologia, 37, 5, 2009. Crossref

  37. Mandapathil Magis, Whiteside Theresa L, Targeting human inducible regulatory T cells (Tr1) in patients with cancer: blocking of adenosine–prostaglandin E2cooperation, Expert Opinion on Biological Therapy, 11, 9, 2011. Crossref

  38. Lee Nara, Shin Jung U, Jin Shan, Yun Ki Na, Kim Jin Young, Park Chang Ook, Kim Seo Hyeong, Noh Ji Yeon, Lee Kwang Hoon, Upregulation of CD47 in Regulatory T Cells in Atopic Dermatitis, Yonsei Medical Journal, 57, 6, 2016. Crossref

  39. Morel Penelope A., Lee Robin E.C., Faeder James R., Demystifying the cytokine network: Mathematical models point the way, Cytokine, 98, 2017. Crossref

  40. Frydrychowicz M., Boruczkowski M., Kolecka-Bednarczyk A., Dworacki G., The Dual Role of Treg in Cancer, Scandinavian Journal of Immunology, 86, 6, 2017. Crossref

  41. Flynn Michael J., Hartley John A., The emerging role of anti-CD25 directed therapies as both immune modulators and targeted agents in cancer, British Journal of Haematology, 179, 1, 2017. Crossref

  42. Singh Avneesh K., Chan Joshua L., Seavey Caleb N., Corcoran Philip C., Hoyt Robert F., Lewis Billeta G.T., Thomas Marvin L., Ayares David L., Horvath Keith A., Mohiuddin Muhammad M., CD4+CD25Hi FoxP3+ regulatory T cells in long-term cardiac xenotransplantation, Xenotransplantation, 25, 2, 2018. Crossref

  43. Kaminitz Ayelet, Askenasy Enosh M., Yaniv Isaac, Stein Jerry, Askenasy Nadir, Unutmaz Derya, Apoptosis of Purified CD4+ T Cell Subsets Is Dominated by Cytokine Deprivation and Absence of Other Cells in New Onset Diabetic NOD Mice, PLoS ONE, 5, 12, 2010. Crossref

  44. Hossain Mohammad S., Kunter Ghada M., El-Najjar Vicky F., Jaye David L., Al-Kadhimi Zaid, Taofeek Owonikoko K., Li Jian-Ming, Waller Edmund K., Bönig Halvard, PD-1 and CTLA-4 up regulation on donor T cells is insufficient to prevent GvHD in allo-HSCT recipients, PLOS ONE, 12, 9, 2017. Crossref

  45. Tselios Konstantinos, Sarantopoulos Alexandros, Gkougkourelas Ioannis, Boura Panagiota, T Regulatory Cells in Systemic Lupus Erythematosus: Current Knowledge and Future Prospects, in Lupus, 2017. Crossref

  46. Dolganiuc Angela, Szabo Gyongyi, T cells with regulatory activity in hepatitis C virus infection: what we know and what we don't, Journal of Leukocyte Biology, 84, 3, 2008. Crossref

  47. Raimondi Giorgio, Sumpter Tina L., Matta Benjamin M., Pillai Mahesh, Corbitt Natasha, Vodovotz Yoram, Wang Zhiliang, Thomson Angus W., Mammalian Target of Rapamycin Inhibition and Alloantigen-Specific Regulatory T Cells Synergize To Promote Long-Term Graft Survival in Immunocompetent Recipients, The Journal of Immunology, 184, 2, 2010. Crossref

  48. Shanmugasundaram Revathi, Selvaraj Ramesh K., Regulatory T Cell Properties of Chicken CD4+CD25+ Cells, The Journal of Immunology, 186, 4, 2011. Crossref

  49. Zhang Yalu, Liu Qiaofei, Liao Quan, Long noncoding RNA: a dazzling dancer in tumor immune microenvironment, Journal of Experimental & Clinical Cancer Research, 39, 1, 2020. Crossref

  50. Khalifian Saami, Raimondi Giorgio, Lee WP Andrew, Brandacher Gerald, Taming inflammation by targeting cytokine signaling: new perspectives in the induction of transplantation tolerance, Immunotherapy, 6, 5, 2014. Crossref

  51. Georgoudaki Anna-Maria, Sutlu Tolga, Alici Evren, Suicide gene therapy for graft-versus-host disease, Immunotherapy, 2, 4, 2010. Crossref

  52. Sun Jijun, Liu Ruiling, He Xiaozhen, Bian Jiang, Zhao Wenbo, Shi Weiyun, Ruan Qingguo, MicroRNA-21 Regulates Diametrically Opposed Biological Functions of Regulatory T Cells, Frontiers in Immunology, 12, 2021. Crossref

  53. Lotfi Ramin, Kaltenmeier Christof, Lotze Michael T., Bergmann Christoph, Until Death Do Us Part: Necrosis and Oxidation Promote the Tumor Microenvironment, Transfusion Medicine and Hemotherapy, 43, 2, 2016. Crossref

  54. Miskov-Zivanov Natasa, Turner Michael S., Kane Lawrence P., Morel Penelope A., Faeder James R., The Duration of T Cell Stimulation Is a Critical Determinant of Cell Fate and Plasticity, Science Signaling, 6, 300, 2013. Crossref

  55. Guinn B A, Mulherkar R, International progress in cancer gene therapy, Cancer Gene Therapy, 15, 12, 2008. Crossref

  56. Choi Myoung Suk, Park Soojin, Choi Taewon, Lee Gihyun, Haam Kyoung-Keun, Hong Moo-Chang, Min Byung-Il, Bae Hyunsu, Bee venom ameliorates ovalbumin induced allergic asthma via modulating CD4+CD25+ regulatory T cells in mice, Cytokine, 61, 1, 2013. Crossref

  57. Seddiki Nabila, Kelleher Anthony D., Regulatory T cells in HIV infection: Who’s suppressing what?, Current HIV/AIDS Reports, 5, 1, 2008. Crossref

  58. Seddiki Nabila, Kelleher Anthony D., Regulatory T cells in HIV infection: Who’s suppressing what?, Current Infectious Disease Reports, 10, 3, 2008. Crossref

  59. Lian Jiachun, Liang Yanfang, Zhang Hailiang, Lan Minsheng, Ye Ziyu, Lin Bihua, Qiu Xianxiu, Zeng Jincheng, The role of polyamine metabolism in remodeling immune responses and blocking therapy within the tumor immune microenvironment, Frontiers in Immunology, 13, 2022. Crossref

  60. Alhaddad Lina, Osipov Andreyan N., Leonov Sergey, The Molecular and Cellular Strategies of Glioblastoma and Non-Small-Cell Lung Cancer Cells Conferring Radioresistance, International Journal of Molecular Sciences, 23, 21, 2022. Crossref

1292 Article views 191 Article downloads Metrics
1292 VIEWS 191 DOWNLOADS 60 Crossref CITATIONS Google
Scholar CITATIONS

Articles with similar content:

Dendritic Cell Editing by Natural Killer Cells Critical Reviews™ in Oncogenesis, Vol.19, 2014, issue 1-2
Guido Ferlazzo, Lorenzo Moretta
Tumor Antigen Presentation by Dendritic Cells Critical Reviews™ in Immunology, Vol.30, 2010, issue 4
Nina Dickgreber, Ian F. Hermans, Troels R. Petersen
Regulation of Dendritic- and T-Cell Fate by Injury-Associated Endogenous Signals Critical Reviews™ in Immunology, Vol.29, 2009, issue 1
Marco E. Bianchi, Annalisa Capobianco, Angelo A. Manfredi, Patrizia Rovere-Querini
Targeting the V-Type Immunoglobulin Domain-Containing Suppressor to T Cell Activation (VISTA) with Agonist Monoclonal Antibodies in Autoimmunity Critical Reviews™ in Immunology, Vol.42, 2022, issue 4
Megan Jung, Benjamin Bonavida
Immunologic Nonresponsiveness to Tumors Critical Reviews™ in Oncogenesis, Vol.9, 1998, issue 1
Martine Extermann, Scott J. Antonia, Richard A. Flavell

Latest Issue

The Value of Systemic Immune-Inflammation Index and T Cell Subsets in the Severity and Prognosis of Sepsis Hao Zhou MiRNA let-7d-5p Alleviates Inflammatory Responses by Targeting Map3k1 and Inactivating ERK/p38 MAPK Signaling in Microglia Fan Fang, Cheng Chen Mechanistic Insights into Tanshinone IIA in the Amelioration of Post-Thyroidectomy Hypoparathyroidism Xiaoyu Qian, Lin Li, Liang Chen, Chao Shen, Jian Tang Effect of the p-Estrogen Receptor at Serine on Its Function and Breast Growth Yuan Liang, Junhui Qin, Tiancheng Ma, Tong Yang, Zhenyu Ke, Ruian Wang

Forthcoming Articles

Identification of key chondrocyte apoptosis-related genes in osteoarthritis based on weighted gene co-expression network analysis and experimental verification Wei Wang, Junyi Hong, Tianyi Cao, Fusheng Ye, Junwei Gao, Shumei Qin Anoikis and Mitophagy-Related Gene Signature for Predicting the Survival and Tumor Cell Progression in Colon Cancer Jian Shen, Minzhe Li Exploring the mechanism of Isoforskolin against asthma based on network pharmacology and experimental verification Yan Fang, Shibo Sun, Chuang Xiao, Min Li, Yuanyuan Zheng, Anju Zu, Zhuang Luo Identification of a novel five-gene prognostic model for laryngeal cancer associated with mitophagy using integrated bioinformatics analysis and experimental verification Dong Song, Lun Dong, Mei Wang, Xiaoping Gao Function of steroid receptor coactivators (SRCs) in T cells and cancers: Implications for cancer immunotherapy Wencan Zhang, Xu Cao, Hongmin Wu, Xiancai Zhong, Yun Shi, Zuoming Sun Electroacupuncture Alleviates Ischemic Stroke by Activating the mTOR/SREBP1 Pathway Jiawang Lang, Jianchang Luo, Luodan Wang, Wenbin Xu, Jie Jia, Zhipeng Zhao, Boxu Lang KIAA1429 induces the m6A modification of LINC01106 to enhance the malignancy of lung adenocarcinoma cell via JAK/STAT3 pathway Di Xu, Ziming Wang, Fajiu Li Effects of different doses of dexmedetomidine on the prevention of postoperative sleep disturbance and serum neurotransmitter level in patients under general anesthesia Huifei Lu, Fei He, Ying Huang, Zhongliang Wei
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections Prices and Subscription Policies Begell House Contact Us Language English 中文 Русский Português German French Spain